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    ahsg1 alpha-2-HS-glycoprotein 1 [ Danio rerio (zebrafish) ]

    Gene ID: 569558, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ahsg1provided by ZNC
    Official Full Name
    alpha-2-HS-glycoprotein 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041114-50
    See related
    Ensembl:ENSDARG00000026764 AllianceGenome:ZFIN:ZDB-GENE-041114-50
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ahsg; wu:fb63g02; zgc:103687
    Summary
    Predicted to enable endopeptidase inhibitor activity. Predicted to be involved in acute-phase response; negative regulation of bone mineralization; and regulation of inflammatory response. Predicted to be active in extracellular matrix and extracellular region. Is expressed in liver. Human ortholog(s) of this gene implicated in alopecia-mental retardation syndrome 1; coronary artery disease; and type 2 diabetes mellitus. Orthologous to human AHSG (alpha 2-HS glycoprotein). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See ahsg1 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (37874629..37881718)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (37920959..37927975)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488987 Neighboring gene si:dkey-37m8.3 Neighboring gene fetuin B Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Fetal alcohol spectrum disorder predisposes to metabolic abnormalities in adulthood. Weeks O, et al. J Clin Invest, 2020 May 1. PMID 32202514, Free PMC Article
    2. Zebrafish as a potential model organism for drug test against hepatitis C virus. Ding CB, et al. PLoS One, 2011. PMID 21857967, Free PMC Article
    3. Natural mixtures of persistent organic pollutants (POP) increase weight gain, advance puberty, and induce changes in gene expression associated with steroid hormones and obesity in female zebrafish. Lyche JL, et al. J Toxicol Environ Health A, 2010. PMID 20526952
    4. Natural mixtures of POPs affected body weight gain and induced transcription of genes involved in weight regulation and insulin signaling. Lyche JL, et al. Aquat Toxicol, 2011 Apr. PMID 21356182
    5. Generation and characterization of a novel gne Knockout Model in Zebrafish. Livne H, et al. Front Cell Dev Biol, 2022. PMID 36353515, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC103687, MGC192819

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in acute-phase response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of bone mineralization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-2-HS-glycoprotein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212622.2 → NP_997787.2  alpha-2-HS-glycoprotein 1 precursor

      Status: VALIDATED

      Source sequence(s)
      EH504898, EH520076, EH531076, FO082298
      UniProtKB/TrEMBL
      Q800S8
      Related
      ENSDARP00000037025.5, ENSDART00000028565.8
      Conserved Domains (2) summary
      smart00043
      Location:142 → 233
      CY; Cystatin-like domain
      cl25751
      Location:295 → 454
      DUF4045; Domain of unknown function (DUF4045)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      37874629..37881718
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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