klf2b Kruppel like factor 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: klf2bprovided by ZNC
Official Full Name: Kruppel like factor 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-011109-2
See related: Ensembl:ENSDARG00000040432 AllianceGenome:ZFIN:ZDB-GENE-011109-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb125; sb:cb125; zgc:91780
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within negative regulation of mesodermal cell fate specification; regulation of ectodermal cell fate specification; and ventricular compact myocardium morphogenesis. Is expressed in several structures, including EVL; cardiovascular system; ectoderm; pectoral fin; and presumptive ectoderm. Orthologous to human KLF2 (KLF transcription factor 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (55665070..55670822)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (17832524..17838270)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These studies provide new insights into how Klf2 regulates cardiovascular development and specifically myocardial wall integrity.
Title: The flow responsive transcription factor Klf2 is required for myocardial wall integrity by modulating Fgf signaling.
reveals a beta1 integrin-Klf2-Egfl7-signaling pathway that is tightly regulated by cerebral cavernous malformation proteins
Title: Regulation of β1 integrin-Klf2-mediated angiogenesis by CCM proteins.
used microarray expression profiles of klf2a, klf2b and klf17 knockdown and overexpression embryos to identify Klf target genes, which reveals that Klfs participate in specification of the extraembryonic enveloping layer
Title: A Pou5f1/Oct4 dependent Klf2a, Klf2b, and Klf17 regulatory sub-network contributes to EVL and ectoderm development during zebrafish embryogenesis.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within heart development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of mesodermal cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of ectodermal cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ventricular compact myocardium morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed

General protein information

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Preferred Names: Krueppel-like factor 2b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131857.2 → NP_571932.1 Krueppel-like factor 2b

See identical proteins and their annotated locations for NP_571932.1

Status: VALIDATED

Source sequence(s)

CU693373

UniProtKB/TrEMBL

A0A2R8QM76, F6NRC6, Q90XE7

Related

ENSDARP00000147221.1, ENSDART00000183814.1

Conserved Domains (4) summary

COG5048
Location:197 → 362

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:282 → 304

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:280 → 304

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:326 → 351

zf-H2C2_2; Zinc-finger double domain