ripk2 receptor-interacting serine-threonine kinase 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ripk2provided by ZNC
Official Full Name: receptor-interacting serine-threonine kinase 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030902-3
See related: Ensembl:ENSDARG00000104290 AllianceGenome:ZFIN:ZDB-GENE-030902-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: RICK
Summary: Predicted to enable CARD domain binding activity and JUN kinase kinase kinase activity. Acts upstream of or within antibacterial innate immune response; defense response to virus; and regulation of DNA-templated transcription. Predicted to be active in cytoplasm. Is expressed in brain; gill; liver; pleuroperitoneal region; and unfertilized egg. Orthologous to human RIPK2 (receptor interacting serine/threonine kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 2

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (7557912..7620260)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (7739609..7772798, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these results firstly demonstrate the antibacterial property of the complete histone H2A against gram-negative bacteria E. piscicida in vivo and the correlation between zebrafish histone H2A and RIP2 adaptor protein on the transcriptional regulation of antibacterial genes and MHC related genes.
Title: Histone H2A cooperates with RIP2 to induce the expression of antibacterial genes and MHC related genes.
Collectively, our works highlight the similarity and discrepancy of NOD1 and RIP2 in the regulation of immune signaling pathways in the zebrafish early ontogenesis, and confirm the crucial role of RIP2 in NLRs signaling and MHC antigen presentation, but not for MAPK and PI3K/Akt pathways
Title: RIP2 Is a Critical Regulator for NLRs Signaling and MHC Antigen Presentation but Not for MAPK and PI3K/Akt Pathways.
unctional analyses of RIPK2 activity in zebrafish embryos indicated that the variant RIPK2104Asp protein is hyperactive in its signaling capacity, with augmented ability to activate the innate immune response and the NF-kappaB pathway and to promote upregulation of OA-associated genes
Title: A hyperactivating proinflammatory RIPK2 allele associated with early-onset osteoarthritis.
The expression of NOD2 and RIPK2 in ZF4 cells was constitutive and induced by infection with Edwardsiella tarda and spring viremia of carp virus (SVCV). NOD2 and RIPK2 can activate NF-kappaB and IFN promoters, inducing significantly antiviral defense against SVCV infection. RIPK2 also has a role in inhibiting the bacterial replication.
Title: NOD2 in zebrafish functions in antibacterial and also antiviral responses via NF-κB, and also MDA5, RIG-I and MAVS.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables CARD domain binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables JUN kinase kinase kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in JNK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within antibacterial innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within defense response to virus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of molecular function	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: receptor-interacting serine/threonine-protein kinase 2

NP_919392.2

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_194411.2 → NP_919392.2 receptor-interacting serine/threonine-protein kinase 2

See identical proteins and their annotated locations for NP_919392.2

Status: PROVISIONAL

Source sequence(s)

BC097049

UniProtKB/TrEMBL

Q4V958

Related

ENSDARP00000134516.1, ENSDART00000160053.2

Conserved Domains (3) summary

cd08786
Location:471 → 557

CARD_RIP2_CARD3; Caspase activation and recruitment domain of Receptor Interacting Protein 2

smart00220
Location:34 → 297

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14026
Location:30 → 313

STKc_RIP2; Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 2