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    CD44 CD44 molecule (IN blood group) [ Homo sapiens (human) ]

    Gene ID: 960, updated on 3-Dec-2024

    Summary

    Official Symbol
    CD44provided by HGNC
    Official Full Name
    CD44 molecule (IN blood group)provided by HGNC
    Primary source
    HGNC:HGNC:1681
    See related
    Ensembl:ENSG00000026508 MIM:107269; AllianceGenome:HGNC:1681
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1; CDW44; CSPG8; H-CAM; HCELL; ECM-III; HUTCH-1; HUTCH-I; ECMR-III; Hermes-1
    Summary
    The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in skin (RPKM 96.7), appendix (RPKM 60.6) and 19 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CD44 in Genome Data Viewer
    Location:
    11p13
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (35139171..35232402)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (35277234..35370499)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (35160718..35253949)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4614 Neighboring gene uncharacterized LOC105376627 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4615 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4616 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:35137568-35138767 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4617 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:35159883-35160447 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:35161615-35162115 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3256 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4618 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:35173058-35173288 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:35173309-35174101 Neighboring gene CD44 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4619 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3257 Neighboring gene NANOG hESC enhancer GRCh37_chr11:35194606-35195107 Neighboring gene small nucleolar RNA, C/D box 164 Neighboring gene NANOG hESC enhancer GRCh37_chr11:35227049-35227813 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:35235787-35236986 Neighboring gene NANOG hESC enhancer GRCh37_chr11:35238494-35239323 Neighboring gene CD44 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4620 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4621 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4622 Neighboring gene solute carrier family 1 member 2 Neighboring gene SLC1A2 antisense RNA 1 Neighboring gene NANOG hESC enhancer GRCh37_chr11:35316953-35317454 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4623 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:35351933-35352492 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:35366234-35366761 Neighboring gene NANOG hESC enhancer GRCh37_chr11:35369348-35369849 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:35440751-35441251 Neighboring gene SLC1A2 antisense RNA 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Blood group, Indian system
    MedGen: C1292298 OMIM: 609027 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo.
    EBI GWAS Catalog
    Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
    EBI GWAS Catalog
    Genome-wide association study identifies three common variants associated with serologic response to vitamin E supplementation in men.
    EBI GWAS Catalog
    Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of CD44 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env CD44, which localizes exclusively to the plasma membrane and is absent from endosomes, is detected at HIV-1 Env budding sites and efficiently incorporated into HIV-1 particles PubMed
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 ectodomain fragment (amino acids 550-639) induces CD44 and beta-actin redistribution to the membrane lipid rafts on the human brain micro vascular endothelial cells PubMed
    Pr55(Gag) gag Basic sequences in the cytoplasmic domains of PSGL-1, CD43, and CD44 are required for efficient association with HIV-1 Gag in HeLa cells PubMed
    gag HIV-1 Gag multimers associate with a specific subset of uropod-directed microdomains (UDMs) containing PSGL-1, CD43, and CD44 PubMed
    Tat tat HIV-1 Tat101 downregulates the expression of CD44 in Jurkat cells PubMed
    Vif vif HIV-1 Vif upregulates the expression of CD44 (Indian blood group) in Vif-expression T cells PubMed
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of CD44 expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
    vpr HIV-1 Vpr potentiates the suppression of CD44 by glucocorticoids via the glucocorticoid receptor pathway PubMed
    matrix gag HIV-1 matrix protein co-localizes with syndecan-2, syndecan-4, and CD44v3 on activated CD4+ T cells to modulate TNF-alpha and IL2 production PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC10468

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables collagen binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    contributes_to cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to cytokine receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables hyaluronic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables hyaluronic acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables hyaluronic acid binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in T cell activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cartilage development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell-cell adhesion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cell-matrix adhesion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to fibroblast growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hyaluronan catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in monocyte aggregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cysteine-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of heterotypic cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of monocyte aggregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of lamellipodium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in wound healing, spreading of cells IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in focal adhesion HDA PubMed 
    located_in lamellipodium membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of macrophage migration inhibitory factor receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of macrophage migration inhibitory factor receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microvillus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in secretory granule membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    CD44 antigen
    Names
    CD44 molecule (Indian blood group)
    GP90 lymphocyte homing/adhesion receptor
    Hermes antigen
    In(Lu) related-p80
    Indian blood group antigen
    cell surface glycoprotein CD44
    chondroitin sulfate proteoglycan 8
    epican
    extracellular matrix receptor III
    hematopoietic cell E- and L-selectin ligand
    heparan sulfate proteoglycan
    homing cell adhesion molecule
    homing function and Indian blood group system
    hyaluronate receptor
    phagocyte glycoprotein 1
    phagocytic glycoprotein 1
    soluble CD44

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008937.1 RefSeqGene

      Range
      5302..98533
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_815

    mRNA and Protein(s)

    1. NM_000610.4NP_000601.3  CD44 antigen isoform 1 precursor

      See identical proteins and their annotated locations for NP_000601.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. It encodes the longest isoform (1).
      Source sequence(s)
      AK127622, AL832642, AY101192, BC004372, BF828674, BF872530, CD721908
      Consensus CDS
      CCDS7897.1
      UniProtKB/Swiss-Prot
      A5YRN9, B6EAT9, D3DR12, D3DR13, O95370, P16070, P22511, Q04858, Q13419, Q13957, Q13958, Q13959, Q13960, Q13961, Q13967, Q13968, Q13980, Q15861, Q16064, Q16065, Q16066, Q16208, Q16522, Q86T72, Q86Z27, Q8N694, Q92493, Q96J24, Q9H5A5, Q9UC28, Q9UC29, Q9UC30, Q9UCB0, Q9UJ36
      Related
      ENSP00000398632.2, ENST00000428726.8
      Conserved Domains (1) summary
      cd03516
      Location:26170
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
    2. NM_001001389.2NP_001001389.1  CD44 antigen isoform 2 precursor

      See identical proteins and their annotated locations for NP_001001389.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. The resulting isoform (2) lacks an internal region, as compared to isoform 1.
      Source sequence(s)
      AK127622, AL832642, AY101192, BC004372, BF828674, CD721908
      Consensus CDS
      CCDS31455.1
      UniProtKB/Swiss-Prot
      P16070
      Related
      ENSP00000389830.2, ENST00000415148.6
      Conserved Domains (1) summary
      cd03516
      Location:26170
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
    3. NM_001001390.2NP_001001390.1  CD44 antigen isoform 3 precursor

      See identical proteins and their annotated locations for NP_001001390.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), also known as CD44R, lacks multiple coding-exons compared to variant 1. The translation remains in-frame. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AK127622, AL832642, AY101192, BG946113, CD721908
      Consensus CDS
      CCDS31456.1
      UniProtKB/Swiss-Prot
      P16070
      Related
      ENSP00000392331.2, ENST00000433892.6
      Conserved Domains (1) summary
      cd03516
      Location:26170
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
    4. NM_001001391.2NP_001001391.1  CD44 antigen isoform 4 precursor

      See identical proteins and their annotated locations for NP_001001391.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks multiple coding-exons compared to variant 1. The translation remains in-frame. The resulting isoform (4) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AK127622, AL832642, AY101192, CD721908
      Consensus CDS
      CCDS31457.1
      UniProtKB/TrEMBL
      A0A385KNS5, A8K309
      Related
      ENSP00000263398.6, ENST00000263398.11
      Conserved Domains (1) summary
      cd03516
      Location:26170
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
    5. NM_001001392.2NP_001001392.1  CD44 antigen isoform 5 precursor

      See identical proteins and their annotated locations for NP_001001392.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks multiple coding-exons compared to variant 1. The translation frame is changed. The resulting isoform (5), also known as CD44 isoform RC, has a distinct and shorter C-terminus, as compared to isoform 1.
      Source sequence(s)
      AK127622, AL832642, AY101192, CD721908, W47313
      Consensus CDS
      CCDS31458.1
      UniProtKB/Swiss-Prot
      P16070
      Related
      ENSP00000278386.6, ENST00000278386.10
      Conserved Domains (1) summary
      cl02612
      Location:2678
      Link_Domain; The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor ...
    6. NM_001202555.2NP_001189484.1  CD44 antigen isoform 6 precursor

      See identical proteins and their annotated locations for NP_001189484.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), also known as CD44R2, lacks multiple coding-exons compared to variant 1. The translation remains in-frame. The resulting isoform (6) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AL133330, AL832642, EF581837
      Consensus CDS
      CCDS55754.1
      UniProtKB/TrEMBL
      A0A385KNS5, A8K309
      Related
      ENSP00000404447.2, ENST00000434472.6
      Conserved Domains (1) summary
      cd03516
      Location:26170
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
    7. NM_001202556.2NP_001189485.1  CD44 antigen isoform 7 precursor

      See identical proteins and their annotated locations for NP_001189485.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks multiple coding-exons compared to variant 1. The translation remains in-frame. The resulting isoform (7) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AL133330, AL832642, FJ216964
      Consensus CDS
      CCDS55755.1
      UniProtKB/TrEMBL
      A0A385KNS5, A8K309
      Related
      ENSP00000309732.6, ENST00000352818.8
      Conserved Domains (1) summary
      cd03516
      Location:26170
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
    8. NM_001202557.2NP_001189486.1  CD44 antigen isoform 8 precursor

      See identical proteins and their annotated locations for NP_001189486.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), also known as Hermes, lacks multiple in-frame coding-exons and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (8) lacks an internal segment and has a shorter and distinct C-terminus, as compared to isoform 1.
      Source sequence(s)
      AL133330, AL832642, M25078
      UniProtKB/TrEMBL
      H0Y5E4
      Related
      ENSP00000398099.2, ENST00000442151.6
      Conserved Domains (1) summary
      cd03516
      Location:26170
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      35139171..35232402
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005253231.4XP_005253288.1  CD44 antigen isoform X1

      Conserved Domains (1) summary
      cd03516
      Location:26170
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
    2. XM_011520482.3XP_011518784.1  CD44 antigen isoform X7

      Conserved Domains (1) summary
      cd03516
      Location:26170
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
    3. XM_005253232.4XP_005253289.1  CD44 antigen isoform X2

      Conserved Domains (1) summary
      cd03516
      Location:26170
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
    4. XM_017018583.3XP_016874072.1  CD44 antigen isoform X6

    5. XM_006718388.3XP_006718451.1  CD44 antigen isoform X3

      Conserved Domains (1) summary
      cd03516
      Location:26170
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
    6. XM_005253239.4XP_005253296.1  CD44 antigen isoform X15

      Conserved Domains (1) summary
      cd03516
      Location:26170
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
    7. XM_005253235.4XP_005253292.1  CD44 antigen isoform X4

      Conserved Domains (1) summary
      cd03516
      Location:26170
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
    8. XM_047427895.1XP_047283851.1  CD44 antigen isoform X5

    9. XM_047427896.1XP_047283852.1  CD44 antigen isoform X10

    10. XM_005253240.4XP_005253297.1  CD44 antigen isoform X18

      See identical proteins and their annotated locations for XP_005253297.1

      Conserved Domains (1) summary
      cd03516
      Location:26170
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
    11. XM_047427902.1XP_047283858.1  CD44 antigen isoform X21

    12. XM_011520483.3XP_011518785.1  CD44 antigen isoform X8

      Conserved Domains (1) summary
      cd03516
      Location:26170
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
    13. XM_047427897.1XP_047283853.1  CD44 antigen isoform X12

    14. XM_011520484.3XP_011518786.1  CD44 antigen isoform X9

      Conserved Domains (1) summary
      cd03516
      Location:26170
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
    15. XM_011520485.3XP_011518787.1  CD44 antigen isoform X11

      Conserved Domains (1) summary
      cd03516
      Location:26170
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
    16. XM_005253238.4XP_005253295.1  CD44 antigen isoform X13

      Conserved Domains (1) summary
      cd03516
      Location:26170
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
    17. XM_047427900.1XP_047283856.1  CD44 antigen isoform X19

    18. XM_047427898.1XP_047283854.1  CD44 antigen isoform X14

    19. XM_047427899.1XP_047283855.1  CD44 antigen isoform X17

    20. XM_047427901.1XP_047283857.1  CD44 antigen isoform X20

    21. XM_011520486.3XP_011518788.1  CD44 antigen isoform X16

      Conserved Domains (1) summary
      cd03516
      Location:26170
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
    22. XM_011520488.3XP_011518790.1  CD44 antigen isoform X23

      See identical proteins and their annotated locations for XP_011518790.1

      UniProtKB/TrEMBL
      A0A385KNS5, A8K309
      Conserved Domains (1) summary
      cd03516
      Location:26170
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
    23. XM_011520487.4XP_011518789.1  CD44 antigen isoform X22

      Conserved Domains (1) summary
      cd03516
      Location:26170
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
    24. XM_047427903.1XP_047283859.1  CD44 antigen isoform X24

    25. XM_011520489.4XP_011518791.1  CD44 antigen isoform X25

      Conserved Domains (1) summary
      cd03516
      Location:26170
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
    26. XM_047427904.1XP_047283860.1  CD44 antigen isoform X27

    27. XM_006718390.5XP_006718453.1  CD44 antigen isoform X26

      Conserved Domains (1) summary
      cd03516
      Location:26170
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      35277234..35370499
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054370559.1XP_054226534.1  CD44 antigen isoform X1

    2. XM_054370565.1XP_054226540.1  CD44 antigen isoform X7

    3. XM_054370560.1XP_054226535.1  CD44 antigen isoform X2

    4. XM_054370564.1XP_054226539.1  CD44 antigen isoform X6

    5. XM_054370561.1XP_054226536.1  CD44 antigen isoform X3

    6. XM_054370573.1XP_054226548.1  CD44 antigen isoform X15

    7. XM_054370562.1XP_054226537.1  CD44 antigen isoform X4

    8. XM_054370563.1XP_054226538.1  CD44 antigen isoform X5

    9. XM_054370568.1XP_054226543.1  CD44 antigen isoform X10

    10. XM_054370576.1XP_054226551.1  CD44 antigen isoform X18

    11. XM_054370579.1XP_054226554.1  CD44 antigen isoform X21

    12. XM_054370566.1XP_054226541.1  CD44 antigen isoform X8

    13. XM_054370570.1XP_054226545.1  CD44 antigen isoform X12

    14. XM_054370567.1XP_054226542.1  CD44 antigen isoform X9

    15. XM_054370569.1XP_054226544.1  CD44 antigen isoform X11

    16. XM_054370571.1XP_054226546.1  CD44 antigen isoform X13

    17. XM_054370577.1XP_054226552.1  CD44 antigen isoform X19

    18. XM_054370572.1XP_054226547.1  CD44 antigen isoform X14

    19. XM_054370575.1XP_054226550.1  CD44 antigen isoform X17

    20. XM_054370578.1XP_054226553.1  CD44 antigen isoform X20

    21. XM_054370574.1XP_054226549.1  CD44 antigen isoform X16

    22. XM_054370581.1XP_054226556.1  CD44 antigen isoform X23

      UniProtKB/TrEMBL
      A0A385KNS5, A8K309
    23. XM_054370580.1XP_054226555.1  CD44 antigen isoform X22

    24. XM_054370582.1XP_054226557.1  CD44 antigen isoform X24

    25. XM_054370583.1XP_054226558.1  CD44 antigen isoform X25

    26. XM_054370585.1XP_054226560.1  CD44 antigen isoform X27

    27. XM_054370584.1XP_054226559.1  CD44 antigen isoform X26