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    COIL coilin [ Homo sapiens (human) ]

    Gene ID: 8161, updated on 9-Dec-2024

    Summary

    Official Symbol
    COILprovided by HGNC
    Official Full Name
    coilinprovided by HGNC
    Primary source
    HGNC:HGNC:2184
    See related
    Ensembl:ENSG00000121058 MIM:600272; AllianceGenome:HGNC:2184
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CLN80; p80-coilin
    Summary
    The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 65.0), thyroid (RPKM 8.3) and 22 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See COIL in Genome Data Viewer
    Location:
    17q22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (56938199..56961050, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (57815838..57838690, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (55015560..55038411, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene mouse mammary tumor virus receptor homolog 2 Neighboring gene tripartite motif containing 25 Neighboring gene microRNA 3614 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12419 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:54990878-54991548 Neighboring gene MPRA-validated peak2907 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:55002389-55002923 Neighboring gene ribosomal protein S15a pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8742 Neighboring gene Sharpr-MPRA regulatory region 7909 Neighboring gene uncharacterized LOC105371836 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8743 Neighboring gene serine carboxypeptidase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables U1 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables U2 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in spliceosomal snRNP assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in Cajal body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Cajal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in fibrillar center IDA
    Inferred from Direct Assay
    more info
     
    located_in membrane HDA PubMed 
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    coilin
    Names
    coilin p80
    p80

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004645.3NP_004636.1  coilin

      See identical proteins and their annotated locations for NP_004636.1

      Status: REVIEWED

      Source sequence(s)
      AC004584, AW021880, BC010385
      Consensus CDS
      CCDS11592.1
      UniProtKB/Swiss-Prot
      B2R931, P38432
      Related
      ENSP00000240316.4, ENST00000240316.5
      Conserved Domains (1) summary
      pfam15862
      Location:7138
      Coilin_N; Coilin N-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      56938199..56961050 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      57815838..57838690 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)