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    UBXN7 UBX domain protein 7 [ Homo sapiens (human) ]

    Gene ID: 26043, updated on 3-Dec-2024

    Summary

    Official Symbol
    UBXN7provided by HGNC
    Official Full Name
    UBX domain protein 7provided by HGNC
    Primary source
    HGNC:HGNC:29119
    See related
    Ensembl:ENSG00000163960 MIM:616379; AllianceGenome:HGNC:29119
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UBXD7
    Summary
    Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; ubiquitin binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in nucleoplasm. Part of VCP-NPL4-UFD1 AAA ATPase complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 8.3), testis (RPKM 7.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See UBXN7 in Genome Data Viewer
    Location:
    3q29
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (196347662..196432427, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (199066970..199151765, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (196074533..196159298, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene TM4SF19-DYNLT2B readthrough (NMD candidate) Neighboring gene TM4SF19 antisense RNA 1 Neighboring gene transmembrane 4 L six family member 19 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:196064783-196065982 Neighboring gene RNA, U6 small nuclear 910, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:196107701-196108278 Neighboring gene RNA, U6 small nuclear 1279, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 434, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 738, pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:196158055-196158829 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:196158830-196159603 Neighboring gene ZDHHC1 pseudogene 1 Neighboring gene UBXN7 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15063 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15064 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21090 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21091 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21092 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:196197078-196197254 Neighboring gene ring finger protein 168 Neighboring gene uncharacterized LOC105374306 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:196228749-196229433 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:196229434-196230117 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15065 Neighboring gene uncharacterized LOC105374307 Neighboring gene single-pass membrane protein with coiled-coil domains 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0794

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of VCP-NPL4-UFD1 AAA ATPase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    UBX domain-containing protein 7
    Names
    UBX domain containing 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015562.2NP_056377.1  UBX domain-containing protein 7

      See identical proteins and their annotated locations for NP_056377.1

      Status: VALIDATED

      Source sequence(s)
      AB018337, AC069257, BC028986, BC047420, BG253663, DA119173
      Consensus CDS
      CCDS43191.1
      UniProtKB/Swiss-Prot
      D3DXB3, O94888, Q6ZP77, Q86X20, Q8N327
      Related
      ENSP00000296328.4, ENST00000296328.9
      Conserved Domains (3) summary
      cd02958
      Location:149261
      UAS; UAS family; UAS is a domain of unknown function. Most members of this family are uncharacterized proteins with similarity to FAS-associated factor 1 (FAF1) and ETEA because of the presence of a UAS domain N-terminal to a ubiquitin-associated UBX domain. ...
      cd14345
      Location:1651
      UBA_UBXD7; UBA-like domain found in UBX domain-containing protein 7 (UBXD7) and similar proteins
      cd01773
      Location:412487
      UBX_UBXN7; Ubiquitin regulatory domain X (UBX) found in UBX domain protein 7 (UBXN7) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      196347662..196432427 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011512671.3XP_011510973.1  UBX domain-containing protein 7 isoform X1

      UniProtKB/TrEMBL
      B4E126
      Related
      ENSP00000397256.1, ENST00000428095.1
      Conserved Domains (2) summary
      cd01773
      Location:260341
      Faf1_like1_UBX; Faf1 ike-1 UBX domain
      cd02958
      Location:1113
      UAS; UAS family; UAS is a domain of unknown function. Most members of this family are uncharacterized proteins with similarity to FAS-associated factor 1 (FAF1) and ETEA because of the presence of a UAS domain N-terminal to a ubiquitin-associated UBX domain. ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      199066970..199151765 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346126.1XP_054202101.1  UBX domain-containing protein 7 isoform X1

      UniProtKB/TrEMBL
      B4E126