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    ASIC5 acid sensing ion channel subunit family member 5 [ Homo sapiens (human) ]

    Gene ID: 51802, updated on 27-Nov-2024

    Summary

    Official Symbol
    ASIC5provided by HGNC
    Official Full Name
    acid sensing ion channel subunit family member 5provided by HGNC
    Primary source
    HGNC:HGNC:17537
    See related
    Ensembl:ENSG00000256394 MIM:616693; AllianceGenome:HGNC:17537
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    INAC; ACCN5; HINAC
    Summary
    This gene belongs to the amiloride-sensitive Na+ channel and degenerin (NaC/DEG) family, members of which have been identified in many animal species ranging from the nematode to human. The amiloride-sensitive Na(+) channel encoded by this gene is primarily expressed in the small intestine, however, its exact function is not known. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ASIC5 in Genome Data Viewer
    Location:
    4q32.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (155829729..155866277, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (159162518..159198985, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (156750881..156787429, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene guanylate cyclase 1 soluble subunit alpha 1 Neighboring gene uncharacterized LOC105377506 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15769 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15770 Neighboring gene guanylate cyclase 1 soluble subunit beta 1 Neighboring gene uncharacterized LOC105377507 Neighboring gene tryptophan 2,3-dioxygenase Neighboring gene cathepsin O

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ligand-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables proton channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    acid-sensing ion channel 5
    Names
    acid sensing (proton gated) ion channel family member 5
    acid sensing ion channel family member 5
    amiloride-sensitive cation channel 5, intestinal
    amiloride-sensitive sodium channel
    human intestine Na(+) channel

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017419.3NP_059115.1  acid-sensing ion channel 5

      See identical proteins and their annotated locations for NP_059115.1

      Status: REVIEWED

      Source sequence(s)
      AC093830, AJ252011
      Consensus CDS
      CCDS3793.1
      UniProtKB/Swiss-Prot
      Q9NY37
      UniProtKB/TrEMBL
      A0A0G2JLG4
      Related
      ENSP00000442477.2, ENST00000537611.3
      Conserved Domains (1) summary
      pfam00858
      Location:41466
      ASC; Amiloride-sensitive sodium channel

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      155829729..155866277 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017008291.2XP_016863780.1  acid-sensing ion channel 5 isoform X1

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NW_003315914.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      1271..30900 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      159162518..159198985 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054350179.1XP_054206154.1  acid-sensing ion channel 5 isoform X1