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    ZFAND3 zinc finger AN1-type containing 3 [ Homo sapiens (human) ]

    Gene ID: 60685, updated on 9-Dec-2024

    Summary

    Official Symbol
    ZFAND3provided by HGNC
    Official Full Name
    zinc finger AN1-type containing 3provided by HGNC
    Primary source
    HGNC:HGNC:18019
    See related
    Ensembl:ENSG00000156639 MIM:607455; AllianceGenome:HGNC:18019
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TEX27
    Summary
    Predicted to enable DNA binding activity and zinc ion binding activity. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis (RPKM 29.7), thyroid (RPKM 22.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZFAND3 in Genome Data Viewer
    Location:
    6p21.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (37819727..38154624)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (37644497..37979293)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (37787503..38122400)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24477 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17144 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:37663553-37664282 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:37664283-37665012 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17147 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17148 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17149 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17150 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17151 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17152 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17153 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:37695835-37696335 Neighboring gene MAM domain containing glycosylphosphatidylinositol anchor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24478 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:37717757-37718578 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:37730195-37730696 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:37744227-37744777 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:37744845-37745776 Neighboring gene Sharpr-MPRA regulatory regions 13021 and 15353 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_91469 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24480 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:37787069-37787871 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17156 Neighboring gene ZFAND3 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17157 Neighboring gene MPRA-validated peak5795 silencer Neighboring gene RNA, 7SL, cytoplasmic 285, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24481 Neighboring gene MPRA-validated peak5796 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:37849025-37849590 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17158 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17159 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:37896413-37896914 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17160 Neighboring gene RNA, variant U1 small nuclear 33 Neighboring gene Sharpr-MPRA regulatory region 1536 Neighboring gene ITGAE pseudogene 1 Neighboring gene NANOG hESC enhancer GRCh37_chr6:38087202-38088004 Neighboring gene uncharacterized LOC124901314 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:38105943-38106787 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:38120813-38121433 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:38129468-38130436 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:38135966-38136596 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:38136597-38137228 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:38137229-38137860 Neighboring gene uncharacterized LOC124901315 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:38159455-38159964 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:38159965-38160474 Neighboring gene uncharacterized LOC124901525 Neighboring gene BTB domain containing 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
    EBI GWAS Catalog
    Genome-wide detection of allele specific copy number variation associated with insulin resistance in African Americans from the HyperGEN study.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ13222, FLJ17799

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    AN1-type zinc finger protein 3
    Names
    testis expressed sequence 27
    testis-expressed protein 27
    zinc finger, AN1-type domain 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410904.1NP_001397833.1  AN1-type zinc finger protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL121574, AL133377, AL589655
      Consensus CDS
      CCDS93913.1
      UniProtKB/TrEMBL
      E2QRF5
      Related
      ENSP00000362489.2, ENST00000373391.6
    2. NM_021943.3NP_068762.1  AN1-type zinc finger protein 3 isoform 1

      See identical proteins and their annotated locations for NP_068762.1

      Status: VALIDATED

      Source sequence(s)
      AI817165, AL137302, AW023961, BC031481, BP305887
      Consensus CDS
      CCDS4836.1
      UniProtKB/Swiss-Prot
      Q5SZZ0, Q5SZZ1, Q9H8U3
      Related
      ENSP00000287218.4, ENST00000287218.9
      Conserved Domains (2) summary
      pfam01428
      Location:160194
      zf-AN1; AN1-like Zinc finger
      pfam01754
      Location:1936
      zf-A20; A20-like zinc finger

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      37819727..38154624
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011514790.3XP_011513092.1  AN1-type zinc finger protein 3 isoform X2

      Conserved Domains (1) summary
      pfam01754
      Location:1936
      zf-A20; A20-like zinc finger
    2. XM_017011171.3XP_016866660.1  AN1-type zinc finger protein 3 isoform X1

      Conserved Domains (1) summary
      pfam01428
      Location:144178
      zf-AN1; AN1-like Zinc finger

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      37644497..37979293
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356171.1XP_054212146.1  AN1-type zinc finger protein 3 isoform X2

    2. XM_054356170.1XP_054212145.1  AN1-type zinc finger protein 3 isoform X1