U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    STK31 serine/threonine kinase 31 [ Homo sapiens (human) ]

    Gene ID: 56164, updated on 3-Dec-2024

    Summary

    Official Symbol
    STK31provided by HGNC
    Official Full Name
    serine/threonine kinase 31provided by HGNC
    Primary source
    HGNC:HGNC:11407
    See related
    Ensembl:ENSG00000196335 MIM:605790; AllianceGenome:HGNC:11407
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TDRD8; SGK396
    Summary
    This gene is similar to a mouse gene that encodes a putative protein kinase with a tudor domain, and shows testis-specific expression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward testis (RPKM 35.6) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See STK31 in Genome Data Viewer
    Location:
    7p15.3
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (23710082..23832513)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (23849359..23971746)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (23749838..23872132)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 126 Neighboring gene FCF1 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:23694754-23695254 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18015 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25739 Neighboring gene family with sequence similarity 221 member A Neighboring gene NANOG hESC enhancer GRCh37_chr7:23763155-23763682 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:23763683-23764210 Neighboring gene protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 pseudogene 3 Neighboring gene MPRA-validated peak6439 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:23867512-23868012 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:23884086-23884586 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:23884587-23885087 Neighboring gene TPT1 pseudogene 7 Neighboring gene small nucleolar RNA U13 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:23958471-23959023 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18016 Neighboring gene uncharacterized LOC105375188

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ16102

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in acrosomal vesicle IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase 31
    Names
    serine/threonine-protein kinase NYD-SPK
    sugen kinase 396
    testis tissue sperm-binding protein Li 78m
    tudor domain containing 8
    NP_001247433.1
    NP_001247434.1
    NP_113602.2
    NP_116562.2
    XP_006715821.1
    XP_011513751.2
    XP_011513752.1
    XP_011513754.2
    XP_054214627.1
    XP_054214628.1
    XP_054214629.1
    XP_054214630.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001260504.2NP_001247433.1  serine/threonine-protein kinase 31 isoform b

      See identical proteins and their annotated locations for NP_001247433.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding region, and initiates translation at a downstream AUG compared to variant 1. The resulting protein (isoform b) has a shorter N-terminus compared to isoform 1. Variants 2 and 4 encode the same protein.
      Source sequence(s)
      AA315045, AC003087, AC008176, AF332194, AK131214, DA533364
      Consensus CDS
      CCDS43556.1
      UniProtKB/TrEMBL
      A0A140VKG1, A4D160
      Related
      ENSP00000346660.3, ENST00000354639.7
      Conserved Domains (2) summary
      cd20430
      Location:38112
      Tudor_TDRD8; Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins
      cl21453
      Location:805945
      PKc_like; Protein Kinases, catalytic domain
    2. NM_001260505.2NP_001247434.1  serine/threonine-protein kinase 31 isoform c

      See identical proteins and their annotated locations for NP_001247434.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The resulting protein (isoform c) is shorter and has a distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC003087, AC008176, AK302689
      Consensus CDS
      CCDS59049.1
      UniProtKB/TrEMBL
      A4D159
      Related
      ENSP00000411852.2, ENST00000433467.6
      Conserved Domains (3) summary
      cd04508
      Location:89129
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      pfam00567
      Location:29147
      TUDOR; Tudor domain
      cl21453
      Location:802986
      PKc_like; Protein Kinases, catalytic domain
    3. NM_031414.5NP_113602.2  serine/threonine-protein kinase 31 isoform a

      See identical proteins and their annotated locations for NP_113602.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC003087, BC059374, DB065148
      Consensus CDS
      CCDS5386.1
      UniProtKB/Swiss-Prot
      B4DZ06, B7WPP5, C9J4F9, Q6PCD3, Q9BXH8, Q9BXU1
      UniProtKB/TrEMBL
      A4D159
      Related
      ENSP00000348132.3, ENST00000355870.8
      Conserved Domains (3) summary
      cd04508
      Location:89129
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      pfam00567
      Location:29147
      TUDOR; Tudor domain
      cl21453
      Location:802921
      PKc_like; Protein Kinases, catalytic domain
    4. NM_032944.4NP_116562.2  serine/threonine-protein kinase 31 isoform b

      See identical proteins and their annotated locations for NP_116562.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice-site in the 5' end that results in translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform b) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AC003087, AC008176, BC059374, DB095141
      Consensus CDS
      CCDS43556.1
      UniProtKB/TrEMBL
      A0A140VKG1, A4D160
      Conserved Domains (2) summary
      cd20430
      Location:38112
      Tudor_TDRD8; Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins
      cl21453
      Location:805945
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. NR_048542.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in a 5' exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA315045, AC003087, AC008176, AK131214, BC033018, DB089624

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      23710082..23832513
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011515452.4XP_011513754.2  serine/threonine-protein kinase 31 isoform X3

      UniProtKB/TrEMBL
      A4D160
    2. XM_011515449.4XP_011513751.2  serine/threonine-protein kinase 31 isoform X1

      UniProtKB/TrEMBL
      A4D160
      Related
      ENSP00000519677.1, ENST00000528479.6
    3. XM_006715758.5XP_006715821.1  serine/threonine-protein kinase 31 isoform X4

      UniProtKB/TrEMBL
      A4D159
      Conserved Domains (3) summary
      cd04508
      Location:89129
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      pfam00567
      Location:29147
      TUDOR; Tudor domain
      cl21453
      Location:624743
      PKc_like; Protein Kinases, catalytic domain
    4. XM_011515450.2XP_011513752.1  serine/threonine-protein kinase 31 isoform X2

      See identical proteins and their annotated locations for XP_011513752.1

      UniProtKB/TrEMBL
      A0A140VKG1, A4D160
      Conserved Domains (2) summary
      cd20430
      Location:38112
      Tudor_TDRD8; Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins
      cl21453
      Location:805945
      PKc_like; Protein Kinases, catalytic domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      23849359..23971746
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358654.1XP_054214629.1  serine/threonine-protein kinase 31 isoform X3

      UniProtKB/TrEMBL
      A4D160
    2. XM_054358652.1XP_054214627.1  serine/threonine-protein kinase 31 isoform X1

      UniProtKB/TrEMBL
      A4D160
    3. XM_054358655.1XP_054214630.1  serine/threonine-protein kinase 31 isoform X4

      UniProtKB/TrEMBL
      A4D159
    4. XM_054358653.1XP_054214628.1  serine/threonine-protein kinase 31 isoform X2

      UniProtKB/TrEMBL
      A0A140VKG1, A4D160

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001122833.1: Suppressed sequence

      Description
      NM_001122833.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.