U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    NMRK1 nicotinamide riboside kinase 1 [ Homo sapiens (human) ]

    Gene ID: 54981, updated on 3-Dec-2024

    Summary

    Official Symbol
    NMRK1provided by HGNC
    Official Full Name
    nicotinamide riboside kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:26057
    See related
    Ensembl:ENSG00000106733 MIM:608704; AllianceGenome:HGNC:26057
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NRK1; C9orf95; bA235O14.2
    Summary
    Nicotinamide adenine dinucleotide (NAD+) is essential for life in all organisms, both as a coenzyme for oxidoreductases and as a source of ADP-ribosyl groups used in various reactions. Nicotinic acid and nicotinamide, collectively known as niacin, are the vitamin precursors of NAD+. Nicotinamide riboside kinases, such as NRK1, function to synthesize NAD+ through nicotinamide mononucleotide using nicotinamide riboside as the precursor (Bieganowski and Brenner, 2004 [PubMed 15137942]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 7.5), skin (RPKM 6.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NMRK1 in Genome Data Viewer
    Location:
    9q21.13
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (75060577..75088155, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (87217117..87244685, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (77675493..77703071, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28468 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19951 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19952 Neighboring gene CARNMT1 antisense RNA 1 Neighboring gene chromosome 9 open reading frame 40 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:77579717-77580289 Neighboring gene carnosine N-methyltransferase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28469 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28470 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19953 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19954 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19955 Neighboring gene osteoclast stimulating factor 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:77751669-77752168 Neighboring gene uncharacterized LOC105376090

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ20559

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nicotinate riboside kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ribosylnicotinamide kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables ribosylnicotinamide kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ribosylnicotinate kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in NAD biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in NAD metabolic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    nicotinamide riboside kinase 1
    Names
    NRK 1
    RNK 1
    nicotinic acid riboside kinase 1
    nmR-K 1
    ribosylnicotinamide kinase 1
    ribosylnicotinic acid kinase 1
    NP_001121075.1
    NP_001317607.1
    NP_001317608.1
    NP_060351.1
    XP_006717226.1
    XP_011517119.1
    XP_016870357.1
    XP_016870359.1
    XP_016870363.1
    XP_047279503.1
    XP_047279504.1
    XP_047279505.1
    XP_047279506.1
    XP_054219165.1
    XP_054219166.1
    XP_054219167.1
    XP_054219168.1
    XP_054219169.1
    XP_054219170.1
    XP_054219171.1
    XP_054219172.1
    XP_054219173.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127603.2NP_001121075.1  nicotinamide riboside kinase 1 isoform 2

      See identical proteins and their annotated locations for NP_001121075.1

      Status: VALIDATED

      Source sequence(s)
      AL133548, BC036804
      Consensus CDS
      CCDS47981.1
      UniProtKB/TrEMBL
      B3KUG3
      Related
      ENSP00000366004.4, ENST00000376808.8
      Conserved Domains (1) summary
      cd02024
      Location:5136
      NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...
    2. NM_001330678.2NP_001317607.1  nicotinamide riboside kinase 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AA412267, AK097144, AL133548, BC036804, CA440629
      Consensus CDS
      CCDS83374.1
      UniProtKB/TrEMBL
      B3KUG3, Q5W125
      Related
      ENSP00000366007.1, ENST00000376811.5
      Conserved Domains (1) summary
      cd02024
      Location:12164
      NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...
    3. NM_001330679.2NP_001317608.1  nicotinamide riboside kinase 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AA412267, AK097144, AL133548, AL555401, BE502779, CA440629
      Consensus CDS
      CCDS83374.1
      UniProtKB/TrEMBL
      B3KUG3, Q5W125
      Conserved Domains (1) summary
      cd02024
      Location:12164
      NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...
    4. NM_017881.3NP_060351.1  nicotinamide riboside kinase 1 isoform 1

      See identical proteins and their annotated locations for NP_060351.1

      Status: VALIDATED

      Source sequence(s)
      AK000566, AL133548, BC036804
      Consensus CDS
      CCDS6650.1
      UniProtKB/Swiss-Prot
      Q5W124, Q8N430, Q9NWW6
      UniProtKB/TrEMBL
      B3KUG3
      Related
      ENSP00000354387.4, ENST00000361092.9
      Conserved Domains (1) summary
      cd02024
      Location:5160
      NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      75060577..75088155 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017014874.2XP_016870363.1  nicotinamide riboside kinase 1 isoform X4

      UniProtKB/TrEMBL
      B3KUG3
      Conserved Domains (1) summary
      cd02024
      Location:5136
      NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...
    2. XM_006717163.3XP_006717226.1  nicotinamide riboside kinase 1 isoform X2

      See identical proteins and their annotated locations for XP_006717226.1

      UniProtKB/Swiss-Prot
      Q5W124, Q8N430, Q9NWW6
      UniProtKB/TrEMBL
      B3KUG3
      Conserved Domains (1) summary
      cd02024
      Location:5160
      NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...
    3. XM_047423548.1XP_047279504.1  nicotinamide riboside kinase 1 isoform X1

      UniProtKB/TrEMBL
      B3KUG3, Q5W125
    4. XM_017014868.2XP_016870357.1  nicotinamide riboside kinase 1 isoform X1

      UniProtKB/TrEMBL
      B3KUG3, Q5W125
      Conserved Domains (1) summary
      cd02024
      Location:12164
      NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...
    5. XM_047423549.1XP_047279505.1  nicotinamide riboside kinase 1 isoform X2

      UniProtKB/Swiss-Prot
      Q5W124, Q8N430, Q9NWW6
      UniProtKB/TrEMBL
      B3KUG3
    6. XM_017014870.3XP_016870359.1  nicotinamide riboside kinase 1 isoform X2

      UniProtKB/Swiss-Prot
      Q5W124, Q8N430, Q9NWW6
      UniProtKB/TrEMBL
      B3KUG3
      Conserved Domains (1) summary
      cd02024
      Location:5160
      NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...
    7. XM_047423547.1XP_047279503.1  nicotinamide riboside kinase 1 isoform X1

      UniProtKB/TrEMBL
      B3KUG3, Q5W125
    8. XM_011518817.2XP_011517119.1  nicotinamide riboside kinase 1 isoform X1

      See identical proteins and their annotated locations for XP_011517119.1

      UniProtKB/TrEMBL
      B3KUG3, Q5W125
      Conserved Domains (1) summary
      cd02024
      Location:12164
      NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...
    9. XM_047423550.1XP_047279506.1  nicotinamide riboside kinase 1 isoform X3

      UniProtKB/TrEMBL
      B3KUG3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      87217117..87244685 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363198.1XP_054219173.1  nicotinamide riboside kinase 1 isoform X4

      UniProtKB/TrEMBL
      B3KUG3
    2. XM_054363194.1XP_054219169.1  nicotinamide riboside kinase 1 isoform X2

      UniProtKB/Swiss-Prot
      Q5W124, Q8N430, Q9NWW6
      UniProtKB/TrEMBL
      B3KUG3
    3. XM_054363193.1XP_054219168.1  nicotinamide riboside kinase 1 isoform X1

      UniProtKB/TrEMBL
      B3KUG3, Q5W125
    4. XM_054363192.1XP_054219167.1  nicotinamide riboside kinase 1 isoform X1

      UniProtKB/TrEMBL
      B3KUG3, Q5W125
    5. XM_054363196.1XP_054219171.1  nicotinamide riboside kinase 1 isoform X2

      UniProtKB/Swiss-Prot
      Q5W124, Q8N430, Q9NWW6
      UniProtKB/TrEMBL
      B3KUG3
    6. XM_054363195.1XP_054219170.1  nicotinamide riboside kinase 1 isoform X2

      UniProtKB/Swiss-Prot
      Q5W124, Q8N430, Q9NWW6
      UniProtKB/TrEMBL
      B3KUG3
    7. XM_054363191.1XP_054219166.1  nicotinamide riboside kinase 1 isoform X1

      UniProtKB/TrEMBL
      B3KUG3, Q5W125
    8. XM_054363190.1XP_054219165.1  nicotinamide riboside kinase 1 isoform X1

      UniProtKB/TrEMBL
      B3KUG3, Q5W125
    9. XM_054363197.1XP_054219172.1  nicotinamide riboside kinase 1 isoform X3

      UniProtKB/TrEMBL
      B3KUG3

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_023352.1: Suppressed sequence

      Description
      NR_023352.1: This RefSeq was removed because it is now thought that this transcript encodes a protein.