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    MORF4L2 mortality factor 4 like 2 [ Homo sapiens (human) ]

    Gene ID: 9643, updated on 9-Dec-2024

    Summary

    Official Symbol
    MORF4L2provided by HGNC
    Official Full Name
    mortality factor 4 like 2provided by HGNC
    Primary source
    HGNC:HGNC:16849
    See related
    Ensembl:ENSG00000123562 MIM:300409; AllianceGenome:HGNC:16849
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MRGX; MORFL2
    Summary
    Involved in positive regulation of double-strand break repair via homologous recombination and regulation of cell cycle. Located in nucleolus; nucleoplasm; and plasma membrane. Part of NuA4 histone acetyltransferase complex and nucleosome. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 110.4), endometrium (RPKM 100.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MORF4L2 in Genome Data Viewer
    Location:
    Xq22.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (103675498..103688047, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (102122473..102135021, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (102930426..102942975, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 5968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29823 Neighboring gene transcription elongation factor A like 1 Neighboring gene CNEP1R1 pseudogene 1 Neighboring gene MORF4L2 antisense RNA 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:102951966-102952716 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:102952717-102953467 Neighboring gene glycine receptor alpha 4 (pseudogene) Neighboring gene transmembrane protein 31 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:102985791-102986664 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:102996691-102997226 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:102997227-102997764 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:103009420-103009920 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:103020819-103021470 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:103022123-103022774 Neighboring gene RAB9B, member RAS oncogene family Neighboring gene proteolipid protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0026

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of NuA4 histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    part_of nucleosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    mortality factor 4-like protein 2
    Names
    MORF-related gene X protein
    MSL3-2 protein
    protein MSL3-2
    transcription factor-like protein MRGX

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142418.2NP_001135890.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001135890.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      BC093013, DC419967
      Consensus CDS
      CCDS14512.1
      UniProtKB/Swiss-Prot
      B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
      UniProtKB/TrEMBL
      B3KX14, Q53EY5
      Conserved Domains (1) summary
      pfam05712
      Location:110276
      MRG
    2. NM_001142419.2NP_001135891.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001135891.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      AL049610, BC093013, DA268606
      Consensus CDS
      CCDS14512.1
      UniProtKB/Swiss-Prot
      B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
      UniProtKB/TrEMBL
      B3KX14, Q53EY5
      Related
      ENSP00000415476.2, ENST00000433176.6
      Conserved Domains (1) summary
      pfam05712
      Location:110276
      MRG
    3. NM_001142420.2NP_001135892.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001135892.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      AL049610, BC093013
      Consensus CDS
      CCDS14512.1
      UniProtKB/Swiss-Prot
      B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
      UniProtKB/TrEMBL
      B3KX14, Q53EY5
      Conserved Domains (1) summary
      pfam05712
      Location:110276
      MRG
    4. NM_001142421.2NP_001135893.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001135893.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      AL049610, BC093013, DA268606
      Consensus CDS
      CCDS14512.1
      UniProtKB/Swiss-Prot
      B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
      UniProtKB/TrEMBL
      B3KX14, Q53EY5
      Related
      ENSP00000353643.1, ENST00000360458.5
      Conserved Domains (1) summary
      pfam05712
      Location:110276
      MRG
    5. NM_001142422.2NP_001135894.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001135894.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      AL049610, BC093013, DA268606
      Consensus CDS
      CCDS14512.1
      UniProtKB/Swiss-Prot
      B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
      UniProtKB/TrEMBL
      B3KX14, Q53EY5
      Conserved Domains (1) summary
      pfam05712
      Location:110276
      MRG
    6. NM_001142423.2NP_001135895.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001135895.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      AL049610, BC093013
      Consensus CDS
      CCDS14512.1
      UniProtKB/Swiss-Prot
      B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
      UniProtKB/TrEMBL
      B3KX14, Q53EY5
      Conserved Domains (1) summary
      pfam05712
      Location:110276
      MRG
    7. NM_001142424.2NP_001135896.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001135896.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      BC093013
      Consensus CDS
      CCDS14512.1
      UniProtKB/Swiss-Prot
      B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
      UniProtKB/TrEMBL
      B3KX14, Q53EY5
      Conserved Domains (1) summary
      pfam05712
      Location:110276
      MRG
    8. NM_001142425.2NP_001135897.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001135897.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      AL049610, BC093013, DA987770
      Consensus CDS
      CCDS14512.1
      UniProtKB/Swiss-Prot
      B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
      UniProtKB/TrEMBL
      B3KX14, Q53EY5
      Conserved Domains (1) summary
      pfam05712
      Location:110276
      MRG
    9. NM_001142426.2NP_001135898.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001135898.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      AL049610, BC093013, DA987770
      Consensus CDS
      CCDS14512.1
      UniProtKB/Swiss-Prot
      B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
      UniProtKB/TrEMBL
      B3KX14, Q53EY5
      Related
      ENSP00000410532.1, ENST00000451301.5
      Conserved Domains (1) summary
      pfam05712
      Location:110276
      MRG
    10. NM_001142427.2NP_001135899.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001135899.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      BC093013, BM835303
      Consensus CDS
      CCDS14512.1
      UniProtKB/Swiss-Prot
      B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
      UniProtKB/TrEMBL
      B3KX14, Q53EY5
      Conserved Domains (1) summary
      pfam05712
      Location:110276
      MRG
    11. NM_001142428.2NP_001135900.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001135900.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      BC093013, DA068448
      Consensus CDS
      CCDS14512.1
      UniProtKB/Swiss-Prot
      B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
      UniProtKB/TrEMBL
      B3KX14, Q53EY5
      Conserved Domains (1) summary
      pfam05712
      Location:110276
      MRG
    12. NM_001142429.2NP_001135901.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001135901.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      BC093013, DC301727
      Consensus CDS
      CCDS14512.1
      UniProtKB/Swiss-Prot
      B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
      UniProtKB/TrEMBL
      B3KX14, Q53EY5
      Conserved Domains (1) summary
      pfam05712
      Location:110276
      MRG
    13. NM_001142430.2NP_001135902.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001135902.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      BC093013, BM471743, DA987770
      Consensus CDS
      CCDS14512.1
      UniProtKB/Swiss-Prot
      B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
      UniProtKB/TrEMBL
      B3KX14, Q53EY5
      Conserved Domains (1) summary
      pfam05712
      Location:110276
      MRG
    14. NM_001142431.2NP_001135903.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001135903.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (15) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      BC093013, DA268606, DC366195
      Consensus CDS
      CCDS14512.1
      UniProtKB/Swiss-Prot
      B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
      UniProtKB/TrEMBL
      B3KX14, Q53EY5
      Conserved Domains (1) summary
      pfam05712
      Location:110276
      MRG
    15. NM_001142432.2NP_001135904.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001135904.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (16) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      BC093013, DC424668
      Consensus CDS
      CCDS14512.1
      UniProtKB/Swiss-Prot
      B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
      UniProtKB/TrEMBL
      B3KX14, Q53EY5
      Conserved Domains (1) summary
      pfam05712
      Location:110276
      MRG
    16. NM_012286.3NP_036418.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_036418.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      AL049610, BC093013, DA987770
      Consensus CDS
      CCDS14512.1
      UniProtKB/Swiss-Prot
      B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
      UniProtKB/TrEMBL
      B3KX14, Q53EY5
      Related
      ENSP00000391969.2, ENST00000441076.7
      Conserved Domains (1) summary
      pfam05712
      Location:110276
      MRG

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      103675498..103688047 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      102122473..102135021 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)