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    Vps8 VPS8 CORVET complex subunit [ Mus musculus (house mouse) ]

    Gene ID: 209018, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Vps8provided by MGI
    Official Full Name
    VPS8 CORVET complex subunitprovided by MGI
    Primary source
    MGI:MGI:2146407
    See related
    Ensembl:ENSMUSG00000033653 AllianceGenome:MGI:2146407
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0804
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in endosomal vesicle fusion. Part of CORVET complex. Is expressed in cranial ganglion; dorsal root ganglion; and neural retina. Orthologous to human VPS8 (VPS8 subunit of CORVET complex). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 7.3), cortex adult (RPKM 6.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Vps8 in Genome Data Viewer
    Location:
    16 B1; 16 12.69 cM
    Exon count:
    50
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (21241859..21463431)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (21423118..21644681)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36224 Neighboring gene predicted gene, 36150 Neighboring gene predicted gene, 53939 Neighboring gene STARR-seq mESC enhancer starr_40364 Neighboring gene STARR-positive B cell enhancer mm9_chr16:21488490-21488791 Neighboring gene predicted gene, 50612 Neighboring gene STARR-positive B cell enhancer ABC_E10895 Neighboring gene STARR-positive B cell enhancer mm9_chr16:21630703-21631004 Neighboring gene STARR-positive B cell enhancer mm9_chr16:21631987-21632288 Neighboring gene RIKEN cDNA 2510009E07 gene Neighboring gene STARR-seq mESC enhancer starr_40369 Neighboring gene STARR-positive B cell enhancer ABC_E11607 Neighboring gene enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Low pup survival rate is associated with maternal Naq3 genotype and hypothalamic Vps8 expression levels in mice. Suto JI, et al. Congenit Anom (Kyoto), 2021 May. PMID 33289187
    2. Mammalian CORVET is required for fusion and conversion of distinct early endosome subpopulations. Perini ED, et al. Traffic, 2014 Dec. PMID 25266290
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Low pup survival rate is associated with maternal Naq3 genotype and hypothalamic Vps8 expression levels in mice.
      Title: Low pup survival rate is associated with maternal Naq3 genotype and hypothalamic Vps8 expression levels in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC38232

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in endosomal vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosomal vesicle fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of CORVET complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CORVET complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of HOPS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    vacuolar protein sorting-associated protein 8 homolog
    Names
    vacuolar protein sorting 8 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081366.1 → NP_001074835.1  vacuolar protein sorting-associated protein 8 homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC130214, AC133597, AC164549
      Conserved Domains (4) summary
      sd00039
      Location:202 → 239
      7WD40; WD40 repeat [structural motif]
      cd16687
      Location:1257 → 1311
      RING-H2_Vps8; RING finger, H2 subclass, found in vacuolar protein sorting-associated protein 8 (Vps8) and similar proteins
      pfam12816
      Location:614 → 796
      Vps8; Golgi CORVET complex core vacuolar protein 8
      cl29593
      Location:197 → 298
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001285893.1 → NP_001272822.1  vacuolar protein sorting-associated protein 8 homolog isoform 1

      See identical proteins and their annotated locations for NP_001272822.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC130214, AC164549, BC055323
      Consensus CDS
      CCDS70701.1
      UniProtKB/Swiss-Prot
      Q0P5W1, Q3UR93, Q80TR5, Q8K280
      Related
      ENSMUSP00000112937.2, ENSMUST00000117598.8
      Conserved Domains (4) summary
      sd00039
      Location:200 → 237
      7WD40; WD40 repeat [structural motif]
      cd16687
      Location:1255 → 1309
      RING-H2_Vps8; RING finger, H2 subclass, found in vacuolar protein sorting-associated protein 8 (Vps8) and similar proteins
      pfam12816
      Location:612 → 794
      Vps8; Golgi CORVET complex core vacuolar protein 8
      cl29593
      Location:195 → 296
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. NM_001285894.1 → NP_001272823.1  vacuolar protein sorting-associated protein 8 homolog isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks two in-frame exons in the coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC130214, AC164549, AK122375
      Consensus CDS
      CCDS70700.1
      Related
      ENSMUSP00000112636.2, ENSMUST00000118923.8
      Conserved Domains (5) summary
      smart00249
      Location:1228 → 1280
      PHD; PHD zinc finger
      pfam12816
      Location:614 → 796
      Vps8; Golgi CORVET complex core vacuolar protein 8
      sd00039
      Location:202 → 239
      7WD40; WD40 repeat [structural motif]
      cl00271
      Location:933 → 1048
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
      cl02567
      Location:197 → 298
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      21241859..21463431
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521955.5 → XP_006522018.1  vacuolar protein sorting-associated protein 8 homolog isoform X1

      See identical proteins and their annotated locations for XP_006522018.1

      Conserved Domains (4) summary
      sd00039
      Location:202 → 239
      7WD40; WD40 repeat [structural motif]
      cd16687
      Location:1257 → 1311
      RING-H2_Vps8; RING finger, H2 subclass, found in vacuolar protein sorting-associated protein 8 (Vps8) and similar proteins
      pfam12816
      Location:614 → 796
      Vps8; Golgi CORVET complex core vacuolar protein 8
      cl29593
      Location:197 → 298
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_036159862.1 → XP_036015755.1  vacuolar protein sorting-associated protein 8 homolog isoform X2

      UniProtKB/Swiss-Prot
      Q0P5W1, Q3UR93, Q80TR5, Q8K280
      Conserved Domains (4) summary
      sd00039
      Location:200 → 237
      7WD40; WD40 repeat [structural motif]
      cd16687
      Location:1255 → 1309
      RING-H2_Vps8; RING finger, H2 subclass, found in vacuolar protein sorting-associated protein 8 (Vps8) and similar proteins
      pfam12816
      Location:612 → 794
      Vps8; Golgi CORVET complex core vacuolar protein 8
      cl29593
      Location:195 → 296
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. XM_006521956.3 → XP_006522019.1  vacuolar protein sorting-associated protein 8 homolog isoform X4

      Conserved Domains (4) summary
      sd00039
      Location:202 → 239
      7WD40; WD40 repeat [structural motif]
      cd16687
      Location:1257 → 1311
      RING-H2_Vps8; RING finger, H2 subclass, found in vacuolar protein sorting-associated protein 8 (Vps8) and similar proteins
      pfam12816
      Location:614 → 796
      Vps8; Golgi CORVET complex core vacuolar protein 8
      cl29593
      Location:197 → 298
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. XM_036159864.1 → XP_036015757.1  vacuolar protein sorting-associated protein 8 homolog isoform X5

      Related
      ENSMUSP00000093905.5, ENSMUST00000096191.11
      Conserved Domains (4) summary
      sd00039
      Location:200 → 237
      7WD40; WD40 repeat [structural motif]
      cd16687
      Location:1255 → 1309
      RING-H2_Vps8; RING finger, H2 subclass, found in vacuolar protein sorting-associated protein 8 (Vps8) and similar proteins
      pfam12816
      Location:612 → 794
      Vps8; Golgi CORVET complex core vacuolar protein 8
      cl29593
      Location:195 → 296
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    5. XM_036159863.1 → XP_036015756.1  vacuolar protein sorting-associated protein 8 homolog isoform X3

      Conserved Domains (4) summary
      sd00039
      Location:202 → 239
      7WD40; WD40 repeat [structural motif]
      cd16687
      Location:1257 → 1311
      RING-H2_Vps8; RING finger, H2 subclass, found in vacuolar protein sorting-associated protein 8 (Vps8) and similar proteins
      pfam12816
      Location:614 → 796
      Vps8; Golgi CORVET complex core vacuolar protein 8
      cl29593
      Location:197 → 298
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    6. XM_036159865.1 → XP_036015758.1  vacuolar protein sorting-associated protein 8 homolog isoform X6

      Conserved Domains (4) summary
      sd00039
      Location:202 → 239
      7WD40; WD40 repeat [structural motif]
      cd16687
      Location:1257 → 1311
      RING-H2_Vps8; RING finger, H2 subclass, found in vacuolar protein sorting-associated protein 8 (Vps8) and similar proteins
      pfam12816
      Location:614 → 796
      Vps8; Golgi CORVET complex core vacuolar protein 8
      cl29593
      Location:197 → 298
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    7. XM_036159861.1 → XP_036015754.1  vacuolar protein sorting-associated protein 8 homolog isoform X2

      UniProtKB/Swiss-Prot
      Q0P5W1, Q3UR93, Q80TR5, Q8K280
      Conserved Domains (4) summary
      sd00039
      Location:200 → 237
      7WD40; WD40 repeat [structural motif]
      cd16687
      Location:1255 → 1309
      RING-H2_Vps8; RING finger, H2 subclass, found in vacuolar protein sorting-associated protein 8 (Vps8) and similar proteins
      pfam12816
      Location:612 → 794
      Vps8; Golgi CORVET complex core vacuolar protein 8
      cl29593
      Location:195 → 296
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    8. XM_006521954.4 → XP_006522017.1  vacuolar protein sorting-associated protein 8 homolog isoform X1

      See identical proteins and their annotated locations for XP_006522017.1

      Conserved Domains (4) summary
      sd00039
      Location:202 → 239
      7WD40; WD40 repeat [structural motif]
      cd16687
      Location:1257 → 1311
      RING-H2_Vps8; RING finger, H2 subclass, found in vacuolar protein sorting-associated protein 8 (Vps8) and similar proteins
      pfam12816
      Location:614 → 796
      Vps8; Golgi CORVET complex core vacuolar protein 8
      cl29593
      Location:197 → 298
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_145948.2: Suppressed sequence

      Description
      NM_145948.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0P5W1.1 GenPept UniProtKB/Swiss-Prot:Q0P5W1

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