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    GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 [ Homo sapiens (human) ]

    Gene ID: 11226, updated on 27-Nov-2024

    Summary

    Official Symbol
    GALNT6provided by HGNC
    Official Full Name
    polypeptide N-acetylgalactosaminyltransferase 6provided by HGNC
    Primary source
    HGNC:HGNC:4128
    See related
    Ensembl:ENSG00000139629 MIM:605148; AllianceGenome:HGNC:4128
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GalNAcT6; GALNAC-T6
    Summary
    This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. The encoded protein is capable of glycosylating fibronectin peptide in vitro and is expressed in a fibroblast cell line, indicating that it may be involved in the synthesis of oncofetal fibronectin. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in stomach (RPKM 18.9), small intestine (RPKM 7.1) and 16 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GALNT6 in Genome Data Viewer
    Location:
    12q13.13
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (51351252..51391673, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (51314062..51354647, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (51745036..51785190, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369767 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6377 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4466 Neighboring gene Sharpr-MPRA regulatory region 12465 Neighboring gene bridging integrator 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6378 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6379 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:51765098-51765664 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:51773037-51773538 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:51773539-51774038 Neighboring gene chymotrypsin like elastase 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:51781791-51782290 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6380 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:51784367-51784952 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:51784953-51785537 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6381 Neighboring gene NANOG hESC enhancer GRCh37_chr12:51813535-51814036 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4468 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4469 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6382 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:51826488-51826988 Neighboring gene SLC4A8 antisense RNA 1 Neighboring gene solute carrier family 4 member 8 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4470 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:51895635-51896136 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:51896137-51896636 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6383 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6384 Neighboring gene NANOG hESC enhancer GRCh37_chr12:51938922-51939423 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4471 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4472 Neighboring gene sodium voltage-gated channel alpha subunit 8 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:52039206-52040092 Neighboring gene SCN8A eExon liver enhancer Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables polypeptide N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables polypeptide N-acetylgalactosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables polypeptide N-acetylgalactosaminyltransferase activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in O-glycan processing TAS
    Traceable Author Statement
    more info
     
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein O-linked glycosylation via threonine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    polypeptide N-acetylgalactosaminyltransferase 6
    Names
    GalNAc transferase 6
    UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 6
    UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 6
    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)
    polypeptide GalNAc transferase 6
    pp-GaNTase 6
    protein-UDP acetylgalactosaminyltransferase 6
    NP_009141.2
    XP_005268664.1
    XP_006719277.1
    XP_011536124.1
    XP_016874234.1
    XP_024304579.1
    XP_024304581.1
    XP_024304582.1
    XP_024304583.1
    XP_024304584.1
    XP_024304585.1
    XP_047284130.1
    XP_047284131.1
    XP_047284132.1
    XP_047284133.1
    XP_047284134.1
    XP_047284135.1
    XP_047284136.1
    XP_047284137.1
    XP_047284138.1
    XP_047284139.1
    XP_054226878.1
    XP_054226879.1
    XP_054226880.1
    XP_054226881.1
    XP_054226882.1
    XP_054226883.1
    XP_054226884.1
    XP_054226885.1
    XP_054226886.1
    XP_054226887.1
    XP_054226888.1
    XP_054226889.1
    XP_054226890.1
    XP_054226891.1
    XP_054226892.1
    XP_054226893.1
    XP_054226894.1
    XP_054226895.1
    XP_054226896.1
    XP_054226897.1
    XP_054226898.1
    XP_054226899.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007210.4NP_009141.2  polypeptide N-acetylgalactosaminyltransferase 6

      See identical proteins and their annotated locations for NP_009141.2

      Status: REVIEWED

      Source sequence(s)
      AC046135, BC035822, DB001644
      Consensus CDS
      CCDS8813.1
      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5
      UniProtKB/TrEMBL
      D7UNW5, Q24JS2
      Related
      ENSP00000348668.2, ENST00000356317.8
      Conserved Domains (2) summary
      cd02510
      Location:180485
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:497619
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      51351252..51391673 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006719214.3XP_006719277.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      See identical proteins and their annotated locations for XP_006719277.1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5
      UniProtKB/TrEMBL
      D7UNW5, Q24JS2
      Conserved Domains (2) summary
      cd02510
      Location:180485
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:497619
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    2. XM_005268607.2XP_005268664.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      See identical proteins and their annotated locations for XP_005268664.1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5
      UniProtKB/TrEMBL
      D7UNW5, Q24JS2
      Related
      ENSP00000444171.1, ENST00000543196.6
      Conserved Domains (2) summary
      cd02510
      Location:180485
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:497619
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    3. XM_047428175.1XP_047284131.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5
    4. XM_024448815.2XP_024304583.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5
      UniProtKB/TrEMBL
      D7UNW5, Q24JS2
      Conserved Domains (2) summary
      cd02510
      Location:180485
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:497619
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    5. XM_011537822.3XP_011536124.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      See identical proteins and their annotated locations for XP_011536124.1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5
      UniProtKB/TrEMBL
      D7UNW5, Q24JS2
      Conserved Domains (2) summary
      cd02510
      Location:180485
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:497619
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    6. XM_017018745.3XP_016874234.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5
      UniProtKB/TrEMBL
      D7UNW5, Q24JS2
      Conserved Domains (2) summary
      cd02510
      Location:180485
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:497619
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    7. XM_024448816.2XP_024304584.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5
      UniProtKB/TrEMBL
      D7UNW5, Q24JS2
      Conserved Domains (2) summary
      cd02510
      Location:180485
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:497619
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    8. XM_024448811.2XP_024304579.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5
      UniProtKB/TrEMBL
      D7UNW5, Q24JS2
      Conserved Domains (2) summary
      cd02510
      Location:180485
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:497619
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    9. XM_047428176.1XP_047284132.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5
    10. XM_047428178.1XP_047284134.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5
    11. XM_047428183.1XP_047284139.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5
    12. XM_024448813.2XP_024304581.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5
      UniProtKB/TrEMBL
      D7UNW5, Q24JS2
      Conserved Domains (2) summary
      cd02510
      Location:180485
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:497619
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    13. XM_047428182.1XP_047284138.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5
    14. XM_047428174.1XP_047284130.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5
    15. XM_047428177.1XP_047284133.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5
    16. XM_024448817.2XP_024304585.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5
      UniProtKB/TrEMBL
      D7UNW5, Q24JS2
      Conserved Domains (2) summary
      cd02510
      Location:180485
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:497619
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    17. XM_024448814.2XP_024304582.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5
      UniProtKB/TrEMBL
      D7UNW5, Q24JS2
      Conserved Domains (2) summary
      cd02510
      Location:180485
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:497619
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    18. XM_047428180.1XP_047284136.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5
    19. XM_047428181.1XP_047284137.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5
    20. XM_047428179.1XP_047284135.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      51314062..51354647 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054370919.1XP_054226894.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5
    2. XM_054370903.1XP_054226878.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5
    3. XM_054370912.1XP_054226887.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5
    4. XM_054370911.1XP_054226886.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5
    5. XM_054370921.1XP_054226896.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5
    6. XM_054370904.1XP_054226879.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5
    7. XM_054370923.1XP_054226898.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5
    8. XM_054370922.1XP_054226897.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5
    9. XM_054370910.1XP_054226885.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5
    10. XM_054370913.1XP_054226888.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5
    11. XM_054370907.1XP_054226882.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5
    12. XM_054370915.1XP_054226890.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5
    13. XM_054370906.1XP_054226881.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5
    14. XM_054370917.1XP_054226892.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5
    15. XM_054370916.1XP_054226891.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5
    16. XM_054370914.1XP_054226889.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5
    17. XM_054370908.1XP_054226883.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5
    18. XM_054370920.1XP_054226895.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5
    19. XM_054370918.1XP_054226893.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5
    20. XM_054370905.1XP_054226880.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5
    21. XM_054370924.1XP_054226899.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5
    22. XM_054370909.1XP_054226884.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q8IYH4, Q8NCL4, Q9H6G2, Q9UIV5