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    Ifitm2 interferon induced transmembrane protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 80876, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Ifitm2provided by MGI
    Official Full Name
    interferon induced transmembrane protein 2provided by MGI
    Primary source
    MGI:MGI:1933382
    See related
    Ensembl:ENSMUSG00000060591 AllianceGenome:MGI:1933382
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mil-3; DSPA2c; Ifitm3l; fragilis3
    Summary
    Involved in negative regulation of viral entry into host cell and response to virus. Acts upstream of or within defense response to virus. Predicted to be located in early endosome membrane; late endosome membrane; and lysosomal membrane. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Is expressed in several structures, including 4-cell stage embryo; brain; genitourinary system; heart; and hemolymphoid system. Human ortholog(s) of this gene implicated in COVID-19. Orthologous to human IFITM2 (interferon induced transmembrane protein 2) and IFITM3 (interferon induced transmembrane protein 3). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in ovary adult (RPKM 557.8), subcutaneous fat pad adult (RPKM 446.6) and 24 other tissues See more
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    Genomic context

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    See Ifitm2 in Genome Data Viewer
    Location:
    7 F5; 7 86.18 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140534750..140539602, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (140954837..140959686, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2853 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:148127673-148127984 Neighboring gene protein glucosylgalactosylhydroxylysine glucosidase Neighboring gene interferon induced transmembrane protein 5 Neighboring gene STARR-seq mESC enhancer starr_20461 Neighboring gene STARR-seq mESC enhancer starr_20462 Neighboring gene interferon induced transmembrane protein 1 Neighboring gene predicted gene 7514

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation. Yánez DC, et al. Eur J Immunol, 2019 Jan. PMID 30365177, Free PMC Article
    2. The Interferon-Stimulated Gene IFITM3 Restricts Infection and Pathogenesis of Arthritogenic and Encephalitic Alphaviruses. Poddar S, et al. J Virol, 2016 Oct 1. PMID 27440901, Free PMC Article
    3. Expression of the mouse fragilis gene products in immune cells and association with receptor signaling complexes. Smith RA, et al. Genes Immun, 2006 Mar. PMID 16395393
    4. Developmentally regulated expression of mil-1 and mil-2, mouse interferon-induced transmembrane protein like genes, during formation and differentiation of primordial germ cells. Tanaka SS, et al. Mech Dev, 2002 Dec. PMID 14516695
    5. The C-terminal sequence of IFITM1 regulates its anti-HIV-1 activity. Jia R, et al. PLoS One, 2015. PMID 25738301, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. this study shows that IFITM2 drives type 2 T helper cell differentiation and exacerbate allergic airway inflammation
      Title: IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102396

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to interferon-beta ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in defense response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within defense response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in heart development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of viral entry into host cell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of viral entry into host cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of viral genome replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to interferon-alpha IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to interferon-beta IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to type II interferon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in type I interferon-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    interferon-induced transmembrane protein 2
    Names
    dispanin subfamily A member 2c
    fragilis R
    fragilis protein 3
    interferon induced transmembrane protein, like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030694.2 → NP_109619.1  interferon-induced transmembrane protein 2

      See identical proteins and their annotated locations for NP_109619.1

      Status: VALIDATED

      Source sequence(s)
      AC162287
      Consensus CDS
      CCDS21994.1
      UniProtKB/Swiss-Prot
      Q3TIG4, Q99J93
      Related
      ENSMUSP00000071470.9, ENSMUST00000081649.10
      Conserved Domains (1) summary
      pfam04505
      Location:54 → 117
      CD225; Interferon-induced transmembrane protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      140534750..140539602 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153595.1 → XP_036009488.1  interferon-induced transmembrane protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q3TIG4, Q99J93
      Conserved Domains (1) summary
      pfam04505
      Location:54 → 117
      CD225; Interferon-induced transmembrane protein

    2. XM_030243121.2 → XP_030098981.1  interferon-induced transmembrane protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q3TIG4, Q99J93
      Conserved Domains (1) summary
      pfam04505
      Location:54 → 117
      CD225; Interferon-induced transmembrane protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99J93.1 GenPept UniProtKB/Swiss-Prot:Q99J93

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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