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    Naa50 N(alpha)-acetyltransferase 50, NatE catalytic subunit [ Mus musculus (house mouse) ]

    Gene ID: 72117, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Naa50provided by MGI
    Official Full Name
    N(alpha)-acetyltransferase 50, NatE catalytic subunitprovided by MGI
    Primary source
    MGI:MGI:1919367
    See related
    Ensembl:ENSMUSG00000022698 AllianceGenome:MGI:1919367
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    San; Mak3; Nat5; Mak3p; Nat13; 2600005K24Rik; 2810441M03Rik
    Summary
    Predicted to enable histone H4 acetyltransferase activity and peptide alpha-N-acetyltransferase activity. Predicted to be involved in N-terminal protein amino acid acetylation; establishment of mitotic sister chromatid cohesion; and mitotic sister chromatid cohesion, centromeric. Predicted to be located in cytosol and nucleolus. Predicted to be part of NatA complex. Is expressed in several structures, including alimentary system; integumental system; nose; respiratory system; and telencephalon. Orthologous to human NAA50 (N-alpha-acetyltransferase 50, NatE catalytic subunit). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 17.1), liver E14 (RPKM 15.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Naa50 in Genome Data Viewer
    Location:
    16 B4; 16 28.47 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (43960154..43983825)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (44139791..44163462)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene GRAM domain containing 1C Neighboring gene microRNA 3470b Neighboring gene STARR-seq mESC enhancer starr_40890 Neighboring gene STARR-seq mESC enhancer starr_40891 Neighboring gene STARR-seq mESC enhancer starr_40894 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit A Neighboring gene STARR-seq mESC enhancer starr_40895 Neighboring gene STARR-positive B cell enhancer ABC_E9932 Neighboring gene STARR-seq mESC enhancer starr_40896 Neighboring gene STARR-positive B cell enhancer ABC_E11613 Neighboring gene STARR-positive B cell enhancer ABC_E2462 Neighboring gene upstream transcription factor family member 3 Neighboring gene SID1 transmembrane family, member 1 Neighboring gene STARR-seq mESC enhancer starr_40897

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NatC Nalpha-terminal acetyltransferase of yeast contains three subunits, Mak3p, Mak10p, and Mak31p. Polevoda B, et al. J Biol Chem, 2001 Jun 8. PMID 11274203
    2. Cloning and characterization of hNAT5/hSAN: an evolutionarily conserved component of the NatA protein N-alpha-acetyltransferase complex. Arnesen T, et al. Gene, 2006 Apr 26. PMID 16507339
    3. Embryonic growth-associated protein is one subunit of a novel N-terminal acetyltransferase complex essential for embryonic vascular development. Wenzlau JM, et al. Circ Res, 2006 Mar 31. PMID 16484612
    4. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article
    5. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone H4 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H4 acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables peptide alpha-N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptide alpha-N-acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables peptide-lysine-N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptide-lysine-N-acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables peptide-methionine-alpha-N-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in N-terminal protein amino acid acetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in N-terminal protein amino acid acetylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in N-terminal protein amino acid acetylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of mitotic sister chromatid cohesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of mitotic sister chromatid cohesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitotic sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic sister chromatid cohesion, centromeric ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic sister chromatid cohesion, centromeric ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of NatA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NatA complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    N-alpha-acetyltransferase 50
    Names
    Mak3 homolog
    Mak3p homolog
    N-acetyltransferase 13
    N-acetyltransferase NAT13
    N-epsilon-acetyltransferase 50
    Nalpha acetyltransferase 50
    natE catalytic subunit
    NP_001334168.1
    NP_082384.1
    XP_036016025.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347239.1 → NP_001334168.1  N-alpha-acetyltransferase 50 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125098, AK167141, AK168394, BC057117, BF020411
      Consensus CDS
      CCDS84236.1
      UniProtKB/Swiss-Prot
      Q3TH79, Q3TK59, Q6PGB6, Q7TML2, Q80VE3, Q9D0Q8
      Related
      ENSMUSP00000124291.2, ENSMUST00000161326.8
      Conserved Domains (1) summary
      COG0456
      Location:10 → 145
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

    2. NM_028108.3 → NP_082384.1  N-alpha-acetyltransferase 50 isoform 1

      See identical proteins and their annotated locations for NP_082384.1

      Status: VALIDATED

      Source sequence(s)
      AC125098
      Consensus CDS
      CCDS28183.1
      UniProtKB/Swiss-Prot
      Q6PGB6
      Related
      ENSMUSP00000070140.9, ENSMUST00000063520.15
      Conserved Domains (1) summary
      COG0456
      Location:9 → 144
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      43960154..43983825
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160132.1 → XP_036016025.1  N-alpha-acetyltransferase 50 isoform X1

      Related
      ENSMUSP00000125517.2, ENSMUST00000159514.8
      Conserved Domains (1) summary
      COG0456
      Location:16 → 151
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PGB6.1 GenPept UniProtKB/Swiss-Prot:Q6PGB6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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