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    Ank2 ankyrin 2, brain [ Mus musculus (house mouse) ]

    Gene ID: 109676, updated on 29-Oct-2024

    Summary

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    Official Symbol
    Ank2provided by MGI
    Official Full Name
    ankyrin 2, brainprovided by MGI
    Primary source
    MGI:MGI:88025
    See related
    Ensembl:ENSMUSG00000032826 AllianceGenome:MGI:88025
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ank-2; Gm4392; 100043364
    Summary
    Enables several functions, including ATPase binding activity; potassium channel regulator activity; and transmembrane transporter binding activity. Involved in several processes, including positive regulation of ion transmembrane transporter activity; regulation of cardiac muscle cell action potential; and regulation of heart contraction. Acts upstream of or within cardiac muscle contraction; regulation of cardiac muscle cell membrane potential; and regulation of cation channel activity. Located in several cellular components, including T-tubule; intercalated disc; and myofibril. Is active in paranodal junction. Is extrinsic component of cytoplasmic side of plasma membrane. Is expressed in central nervous system; eye; genitourinary system; and heart. Used to study ankyrin-B-related cardiac arrhythmia; autistic disorder; and sinoatrial node disease. Human ortholog(s) of this gene implicated in ankyrin-B-related cardiac arrhythmia; atrial fibrillation; long QT syndrome; and sick sinus syndrome. Orthologous to human ANK2 (ankyrin 2). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 17.1), frontal lobe adult (RPKM 13.9) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ank2 in Genome Data Viewer
    Location:
    3 G2; 3 56.07 cM
    Exon count:
    63
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (126715256..127293996, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (126921607..127500347, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08934 Neighboring gene STARR-seq mESC enhancer starr_08935 Neighboring gene predicted gene, 46823 Neighboring gene STARR-positive B cell enhancer mm9_chr3:126278818-126279119 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:126299066-126299249 Neighboring gene STARR-positive B cell enhancer ABC_E7941 Neighboring gene STARR-positive B cell enhancer ABC_E9570 Neighboring gene STARR-positive B cell enhancer ABC_E8805 Neighboring gene calcium/calmodulin-dependent protein kinase II, delta Neighboring gene STARR-positive B cell enhancer mm9_chr3:126393622-126393923 Neighboring gene STARR-positive B cell enhancer ABC_E9571 Neighboring gene VISTA enhancer mm1653 Neighboring gene predicted gene 15551 Neighboring gene STARR-positive B cell enhancer mm9_chr3:126454256-126454557 Neighboring gene STARR-positive B cell enhancer ABC_E11215 Neighboring gene STARR-positive B cell enhancer mm9_chr3:126474504-126474805 Neighboring gene STARR-positive B cell enhancer ABC_E11216 Neighboring gene STARR-seq mESC enhancer starr_08938 Neighboring gene STARR-seq mESC enhancer starr_08939 Neighboring gene STARR-positive B cell enhancer mm9_chr3:126606343-126606644 Neighboring gene STARR-seq mESC enhancer starr_08940 Neighboring gene STARR-seq mESC enhancer starr_08941 Neighboring gene predicted gene, 25501 Neighboring gene STARR-seq mESC enhancer starr_08943 Neighboring gene predicted gene, 16958 Neighboring gene STARR-seq mESC enhancer starr_08946 Neighboring gene STARR-seq mESC enhancer starr_08947 Neighboring gene STARR-positive B cell enhancer mm9_chr3:127025925-127026226 Neighboring gene STARR-seq mESC enhancer starr_08948 Neighboring gene STARR-seq mESC enhancer starr_08950 Neighboring gene predicted gene, 52631 Neighboring gene predicted gene, 35535 Neighboring gene predicted gene, 51018 Neighboring gene microRNA 302b Neighboring gene microRNA 302c Neighboring gene La ribonucleoprotein 7, transcriptional regulator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Elevated local [Ca2+] and CaMKII promote spontaneous Ca2+ release in ankyrin-B-deficient hearts. Popescu I, et al. Cardiovasc Res, 2016 Aug 1. PMID 27131508, Free PMC Article
    2. I(CaL) inhibition prevents arrhythmogenic Ca(2+) waves caused by abnormal Ca(2+) sensitivity of RyR or SR Ca(2+) accumulation. Stokke MK, et al. Cardiovasc Res, 2013 May 1. PMID 23417043
    3. Ankyrin B promotes developmental spine regulation in the mouse prefrontal cortex. Murphy KE, et al. Cereb Cortex, 2023 Oct 9. PMID 37642601, Free PMC Article
    4. Ankyrin-B reduction enhances Ca spark-mediated SR Ca release promoting cardiac myocyte arrhythmic activity. Camors E, et al. J Mol Cell Cardiol, 2012 Jun. PMID 22406428, Free PMC Article
    5. Impact of stress on cardiac phenotypes in mice harboring an ankyrin-B disease variant. Wallace MJ, et al. J Biol Chem, 2023 Jun. PMID 37182735, Free PMC Article

    See all (117) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Physical and functional convergence of the autism risk genes Scn2a and Ank2 in neocortical pyramidal cell dendrites.
      Title: Physical and functional convergence of the autism risk genes Scn2a and Ank2 in neocortical pyramidal cell dendrites.
    2. Ankyrin B promotes developmental spine regulation in the mouse prefrontal cortex.
      Title: Ankyrin B promotes developmental spine regulation in the mouse prefrontal cortex.
    3. Early developmental deletion of forebrain Ank2 causes seizure-related phenotypes by reshaping the synaptic proteome.
      Title: Early developmental deletion of forebrain Ank2 causes seizure-related phenotypes by reshaping the synaptic proteome.
    4. Impact of stress on cardiac phenotypes in mice harboring an ankyrin-B disease variant.
      Title: Impact of stress on cardiac phenotypes in mice harboring an ankyrin-B disease variant.
    5. Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice.
      Title: Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice.
    6. Giant ankyrin-B mediates transduction of axon guidance and collateral branch pruning factor sema 3A.
      Title: Giant ankyrin-B mediates transduction of axon guidance and collateral branch pruning factor sema 3A.
    7. Coupling of the Na+/K+-ATPase to Ankyrin B controls Na+/Ca2+ exchanger activity in cardiomyocytes.
      Title: Coupling of the Na+/K+-ATPase to Ankyrin B controls Na+/Ca2+ exchanger activity in cardiomyocytes.
    8. These novel findings have important implications for understanding the role of AnkB and Cav2.1 in the regulation of neuronal function in health and disease.
      Title: Ankyrin B and Ankyrin B variants differentially modulate intracellular and surface Cav2.1 levels.
    9. findings introduce what we believe to be a new pathway for Arrhythmogenic cardiomyopathy, a role of ankyrin-B in cardiac structure and signaling, a molecular link between ankyrin-B and beta-catenin, and evidence for targeted activation of the WNT/beta-catenin pathway as a potential treatment for this disease.
      Title: Ankyrin-B dysfunction predisposes to arrhythmogenic cardiomyopathy and is amenable to therapy.
    10. Gain of axon branching due to giant ankB deficiency/mutation is a candidate cellular mechanism to explain aberrant structural connectivity and penetrant behavioral consequences in mice as well as humans bearing autism spectrum disorder-related ANK2 mutations.
      Title: ANK2 autism mutation targeting giant ankyrin-B promotes axon branching and ectopic connectivity.
    Submit: New GeneRIF Correction See all GeneRIFs (35)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphorylation-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables potassium channel regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables spectrin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural constituent of cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in SA node cell action potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in SA node cell to atrial cardiac muscle cell communication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in SA node cell to atrial cardiac muscle cell communication ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within T-tubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in T-tubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in atrial cardiac muscle cell action potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in atrial cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in atrial cardiac muscle cell to AV node cell communication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in atrial septum development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cardiac muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of calcium ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cation channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of potassium ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of potassium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to M-band IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to T-tubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to T-tubule IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to cell surface IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to ciliary inversin compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to endoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization to plasma membrane IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of AV node cell action potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of SA node cell action potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of SA node cell action potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of apoptotic process RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    involved_in regulation of atrial cardiac muscle cell action potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of atrial cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of calcium ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cardiac muscle cell contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cardiac muscle cell contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of cardiac muscle cell membrane potential IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cardiac muscle cell membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cardiac muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cardiac muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cardiac muscle contraction by calcium ion signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cardiac muscle contraction by calcium ion signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of cation channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of heart rate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of heart rate by cardiac conduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of heart rate by cardiac conduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein stability IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in regulation of release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of ventricular cardiac muscle cell membrane repolarization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ventricular cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in A band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in M band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in M band IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in T-tubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in T-tubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in costamere IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extrinsic component of cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intercalated disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in paranodal junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in recycling endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sarcolemma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sarcolemma IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ankyrin-2
    Names
    ankyrin-B

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034168.1 → NP_001029340.1  ankyrin-2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK083826, BC043123, BP753425
      UniProtKB/Swiss-Prot
      Q8C8R3
      Conserved Domains (1) summary
      cd08804
      Location:494 → 577
      Death_ank2; Death domain of Ankyrin-2

    2. NM_001327938.1 → NP_001314867.1  ankyrin-2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC102480, AC102591, AC113952, BP753425
      Conserved Domains (8) summary
      smart00218
      Location:961 → 1098
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      smart00248
      Location:525 → 550
      ANK; ankyrin repeats
      COG0666
      Location:302 → 500
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:223 → 348
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:3543 → 3626
      Death_ank2; Death domain of Ankyrin-2
      pfam12796
      Location:233 → 324
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:33 → 80
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:426 → 457
      ANK; ANK repeat [structural motif]

    3. NM_001327939.1 → NP_001314868.1  ankyrin-2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC102480, AC102591, AC105163, BP753425
      Consensus CDS
      CCDS84672.1
      UniProtKB/TrEMBL
      S4R2R5
      Related
      ENSMUSP00000138753.4, ENSMUST00000182078.9
      Conserved Domains (8) summary
      smart00218
      Location:912 → 1016
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      smart00248
      Location:574 → 602
      ANK; ankyrin repeats
      COG0666
      Location:285 → 483
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:206 → 331
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:3461 → 3544
      Death_ank2; Death domain of Ankyrin-2
      pfam12796
      Location:216 → 307
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:16 → 63
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:409 → 440
      ANK; ANK repeat [structural motif]

    4. NM_178655.3 → NP_848770.2  ankyrin-2 isoform 2

      See identical proteins and their annotated locations for NP_848770.2

      Status: VALIDATED

      Source sequence(s)
      AK032060, BC043123, BC059251, BP753425
      Consensus CDS
      CCDS38625.1
      UniProtKB/Swiss-Prot
      Q8C8R3
      Related
      ENSMUSP00000043765.8, ENSMUST00000044443.15
      Conserved Domains (2) summary
      smart00218
      Location:128 → 232
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08804
      Location:611 → 694
      Death_ank2; Death domain of Ankyrin-2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      126715256..127293996 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162834.1 → XP_036018727.1  ankyrin-2 isoform X25

      Conserved Domains (10) summary
      smart00218
      Location:996 → 1133
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2244 → 2651
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:392 → 677
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3193 → 3520
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2741 → 2972
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3578 → 3661
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:418 → 449
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:749 → 801
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1354 → 1483
      UPA_2; UPA domain
      cl39094
      Location:549 → 773
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_036162844.1 → XP_036018737.1  ankyrin-2 isoform X37

      Conserved Domains (11) summary
      smart00218
      Location:971 → 1108
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2219 → 2626
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:25 → 333
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3168 → 3495
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2716 → 2947
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3553 → 3636
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:426 → 457
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:724 → 776
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1329 → 1458
      UPA_2; UPA domain
      pfam12796
      Location:398 → 489
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:473 → 748
      Ank_2; Ankyrin repeats (3 copies)

    3. XM_006500891.3 → XP_006500954.1  ankyrin-2 isoform X28

      Conserved Domains (10) summary
      smart00218
      Location:986 → 1123
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2234 → 2641
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:400 → 685
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3183 → 3510
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2731 → 2962
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3568 → 3651
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:426 → 457
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:757 → 809
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1344 → 1473
      UPA_2; UPA domain
      cl39094
      Location:557 → 781
      Ank_2; Ankyrin repeats (3 copies)

    4. XM_036162832.1 → XP_036018725.1  ankyrin-2 isoform X21

      Conserved Domains (10) summary
      smart00218
      Location:1004 → 1141
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2252 → 2659
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:400 → 685
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3201 → 3528
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2749 → 2980
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3586 → 3669
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:426 → 457
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:757 → 809
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1362 → 1491
      UPA_2; UPA domain
      cl39094
      Location:557 → 781
      Ank_2; Ankyrin repeats (3 copies)

    5. XM_036162820.1 → XP_036018713.1  ankyrin-2 isoform X9

      Conserved Domains (10) summary
      smart00218
      Location:1037 → 1174
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2285 → 2692
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:433 → 718
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3234 → 3561
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2782 → 3013
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3619 → 3702
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:459 → 490
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:790 → 842
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1395 → 1524
      UPA_2; UPA domain
      cl39094
      Location:590 → 814
      Ank_2; Ankyrin repeats (3 copies)

    6. XM_036162849.1 → XP_036018742.1  ankyrin-2 isoform X44

      Conserved Domains (11) summary
      smart00218
      Location:954 → 1091
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2202 → 2609
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:8 → 316
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3151 → 3478
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2699 → 2930
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3536 → 3619
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:409 → 440
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:707 → 759
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1312 → 1441
      UPA_2; UPA domain
      pfam12796
      Location:381 → 472
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:456 → 731
      Ank_2; Ankyrin repeats (3 copies)

    7. XM_036162846.1 → XP_036018739.1  ankyrin-2 isoform X41

      Conserved Domains (10) summary
      smart00218
      Location:965 → 1102
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2213 → 2620
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:383 → 668
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3162 → 3489
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2710 → 2941
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3547 → 3630
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:409 → 440
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:740 → 792
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1323 → 1452
      UPA_2; UPA domain
      cl39094
      Location:540 → 764
      Ank_2; Ankyrin repeats (3 copies)

    8. XM_006500893.4 → XP_006500956.1  ankyrin-2 isoform X39

      Conserved Domains (10) summary
      smart00218
      Location:969 → 1106
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2217 → 2624
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:383 → 668
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3166 → 3493
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2714 → 2945
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3551 → 3634
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:409 → 440
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:740 → 792
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1327 → 1456
      UPA_2; UPA domain
      cl39094
      Location:540 → 764
      Ank_2; Ankyrin repeats (3 copies)

    9. XM_036162835.1 → XP_036018728.1  ankyrin-2 isoform X26

      Conserved Domains (10) summary
      smart00218
      Location:987 → 1124
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2235 → 2642
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:383 → 668
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3184 → 3511
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2732 → 2963
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3569 → 3652
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:409 → 440
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:740 → 792
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1345 → 1474
      UPA_2; UPA domain
      cl39094
      Location:540 → 764
      Ank_2; Ankyrin repeats (3 copies)

    10. XM_036162850.1 → XP_036018743.1  ankyrin-2 isoform X45

      Related
      ENSMUSP00000138620.4, ENSMUST00000182064.9
      Conserved Domains (10) summary
      smart00218
      Location:940 → 1077
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2188 → 2595
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:378 → 663
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3137 → 3464
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2685 → 2916
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3522 → 3605
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:404 → 435
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:735 → 787
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1298 → 1427
      UPA_2; UPA domain
      cl39094
      Location:535 → 759
      Ank_2; Ankyrin repeats (3 copies)

    11. XM_036162840.1 → XP_036018733.1  ankyrin-2 isoform X33

      Conserved Domains (10) summary
      smart00218
      Location:979 → 1116
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2227 → 2634
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:375 → 660
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3176 → 3503
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2724 → 2955
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3561 → 3644
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:401 → 432
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:732 → 784
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1337 → 1466
      UPA_2; UPA domain
      cl39094
      Location:532 → 756
      Ank_2; Ankyrin repeats (3 copies)

    12. XM_036162829.1 → XP_036018722.1  ankyrin-2 isoform X18

      Conserved Domains (10) summary
      smart00218
      Location:1012 → 1149
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2260 → 2667
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:408 → 693
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3209 → 3536
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2757 → 2988
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3594 → 3677
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:434 → 465
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:765 → 817
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1370 → 1499
      UPA_2; UPA domain
      cl39094
      Location:565 → 789
      Ank_2; Ankyrin repeats (3 copies)

    13. XM_036162836.1 → XP_036018729.1  ankyrin-2 isoform X27

      Conserved Domains (10) summary
      smart00218
      Location:987 → 1124
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2235 → 2642
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:392 → 668
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3184 → 3511
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2732 → 2963
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3569 → 3652
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:409 → 440
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:740 → 792
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1345 → 1474
      UPA_2; UPA domain
      cl39094
      Location:540 → 764
      Ank_2; Ankyrin repeats (3 copies)

    14. XM_036162837.1 → XP_036018730.1  ankyrin-2 isoform X29

      Conserved Domains (11) summary
      smart00218
      Location:987 → 1124
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2235 → 2642
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:39 → 349
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3184 → 3511
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2732 → 2963
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3569 → 3652
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:442 → 473
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:740 → 792
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1345 → 1474
      UPA_2; UPA domain
      pfam12796
      Location:414 → 505
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:489 → 764
      Ank_2; Ankyrin repeats (3 copies)

    15. XM_036162825.1 → XP_036018718.1  ankyrin-2 isoform X14

      Conserved Domains (10) summary
      smart00218
      Location:1020 → 1157
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2268 → 2675
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:416 → 701
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3217 → 3544
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2765 → 2996
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3602 → 3685
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:442 → 473
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:773 → 825
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1378 → 1507
      UPA_2; UPA domain
      cl39094
      Location:573 → 797
      Ank_2; Ankyrin repeats (3 copies)

    16. XM_036162843.1 → XP_036018736.1  ankyrin-2 isoform X36

      Conserved Domains (10) summary
      smart00218
      Location:974 → 1111
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2222 → 2629
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:370 → 655
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3171 → 3498
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2719 → 2950
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3556 → 3639
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:396 → 427
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:727 → 779
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1332 → 1461
      UPA_2; UPA domain
      cl39094
      Location:527 → 751
      Ank_2; Ankyrin repeats (3 copies)

    17. XM_036162839.1 → XP_036018732.1  ankyrin-2 isoform X32

      Conserved Domains (10) summary
      smart00218
      Location:982 → 1119
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2230 → 2637
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:378 → 663
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3179 → 3506
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2727 → 2958
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3564 → 3647
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:404 → 435
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:735 → 787
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1340 → 1469
      UPA_2; UPA domain
      cl39094
      Location:535 → 759
      Ank_2; Ankyrin repeats (3 copies)

    18. XM_036162852.1 → XP_036018745.1  ankyrin-2 isoform X47

      Conserved Domains (10) summary
      smart00218
      Location:873 → 1010
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2121 → 2528
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:269 → 554
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3070 → 3397
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2618 → 2849
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3455 → 3538
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:295 → 326
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:626 → 678
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1231 → 1360
      UPA_2; UPA domain
      cl39094
      Location:426 → 650
      Ank_2; Ankyrin repeats (3 copies)

    19. XM_036162847.1 → XP_036018740.1  ankyrin-2 isoform X42

      Conserved Domains (10) summary
      smart00218
      Location:961 → 1098
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2209 → 2616
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:375 → 660
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3158 → 3485
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2706 → 2937
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3543 → 3626
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:401 → 432
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:732 → 784
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1319 → 1448
      UPA_2; UPA domain
      cl39094
      Location:532 → 756
      Ank_2; Ankyrin repeats (3 copies)

    20. XM_036162851.1 → XP_036018744.1  ankyrin-2 isoform X46

      Conserved Domains (11) summary
      smart00218
      Location:936 → 1073
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA02876
      Location:260 → 600
      PHA02876; ankyrin repeat protein; Provisional
      PTZ00449
      Location:2184 → 2591
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:39 → 349
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3133 → 3460
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2681 → 2912
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3518 → 3601
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:640 → 671
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:707 → 759
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1294 → 1423
      UPA_2; UPA domain
      cl39094
      Location:507 → 731
      Ank_2; Ankyrin repeats (3 copies)

    21. XM_030252368.2 → XP_030108228.1  ankyrin-2 isoform X40

      Conserved Domains (11) summary
      smart00218
      Location:969 → 1106
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2217 → 2624
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:39 → 349
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3166 → 3493
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2714 → 2945
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3551 → 3634
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:442 → 473
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:414 → 505
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:740 → 792
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1327 → 1456
      UPA_2; UPA domain
      cl39094
      Location:489 → 764
      Ank_2; Ankyrin repeats (3 copies)

    22. XM_030252365.2 → XP_030108225.1  ankyrin-2 isoform X30

      Conserved Domains (10) summary
      smart00218
      Location:985 → 1122
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2233 → 2640
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:416 → 701
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3182 → 3509
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2730 → 2961
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3567 → 3650
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:442 → 473
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:773 → 825
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1343 → 1472
      UPA_2; UPA domain
      cl39094
      Location:573 → 797
      Ank_2; Ankyrin repeats (3 copies)

    23. XM_006500886.4 → XP_006500949.1  ankyrin-2 isoform X23

      Conserved Domains (10) summary
      smart00218
      Location:1002 → 1139
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2250 → 2657
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:416 → 701
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3199 → 3526
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2747 → 2978
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3584 → 3667
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:442 → 473
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:773 → 825
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1360 → 1489
      UPA_2; UPA domain
      cl39094
      Location:573 → 797
      Ank_2; Ankyrin repeats (3 copies)

    24. XM_036162831.1 → XP_036018724.1  ankyrin-2 isoform X20

      Conserved Domains (10) summary
      smart00218
      Location:1066 → 1203
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2314 → 2721
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:462 → 747
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3263 → 3590
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2811 → 3042
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3648 → 3731
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:488 → 519
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:819 → 871
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1424 → 1553
      UPA_2; UPA domain
      cl39094
      Location:619 → 843
      Ank_2; Ankyrin repeats (3 copies)

    25. XM_036162824.1 → XP_036018717.1  ankyrin-2 isoform X13

      Conserved Domains (10) summary
      smart00218
      Location:1054 → 1158
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2269 → 2676
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:462 → 747
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3218 → 3545
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2766 → 2997
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3603 → 3686
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:488 → 519
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:819 → 871
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1379 → 1508
      UPA_2; UPA domain
      cl39094
      Location:619 → 843
      Ank_2; Ankyrin repeats (3 copies)

    26. XM_036162827.1 → XP_036018720.1  ankyrin-2 isoform X16

      Conserved Domains (10) summary
      smart00218
      Location:1046 → 1150
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2261 → 2668
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:462 → 747
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3210 → 3537
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2758 → 2989
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3595 → 3678
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:488 → 519
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:819 → 871
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1371 → 1500
      UPA_2; UPA domain
      cl39094
      Location:619 → 843
      Ank_2; Ankyrin repeats (3 copies)

    27. XM_036162853.1 → XP_036018746.1  ankyrin-2 isoform X48

      Conserved Domains (7) summary
      smart00218
      Location:1066 → 1203
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA03095
      Location:462 → 747
      PHA03095; ankyrin-like protein; Provisional
      cd08804
      Location:1582 → 1665
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:488 → 519
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:819 → 871
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1424 → 1553
      UPA_2; UPA domain
      cl39094
      Location:619 → 843
      Ank_2; Ankyrin repeats (3 copies)

    28. XM_011239990.1 → XP_011238292.1  ankyrin-2 isoform X8

      Conserved Domains (10) summary
      smart00218
      Location:846 → 983
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2094 → 2501
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:269 → 554
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3043 → 3370
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2591 → 2822
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3428 → 3511
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:295 → 326
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:626 → 678
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1204 → 1333
      UPA_2; UPA domain
      cl39094
      Location:426 → 650
      Ank_2; Ankyrin repeats (3 copies)

    29. XM_011239986.1 → XP_011238288.1  ankyrin-2 isoform X7

      Conserved Domains (10) summary
      smart00218
      Location:851 → 988
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2099 → 2506
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:269 → 554
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3048 → 3375
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2596 → 2827
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3433 → 3516
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:295 → 326
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:626 → 678
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1209 → 1338
      UPA_2; UPA domain
      cl39094
      Location:426 → 650
      Ank_2; Ankyrin repeats (3 copies)

    30. XM_036162817.1 → XP_036018710.1  ankyrin-2 isoform X4

      Conserved Domains (10) summary
      smart00218
      Location:864 → 1001
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2112 → 2519
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:269 → 554
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3061 → 3388
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2609 → 2840
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3446 → 3529
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:295 → 326
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:626 → 678
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1222 → 1351
      UPA_2; UPA domain
      cl39094
      Location:426 → 650
      Ank_2; Ankyrin repeats (3 copies)

    31. XM_036162818.1 → XP_036018711.1  ankyrin-2 isoform X5

      Conserved Domains (10) summary
      smart00218
      Location:861 → 998
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2109 → 2516
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:269 → 554
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3058 → 3385
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2606 → 2837
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3443 → 3526
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:295 → 326
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:626 → 678
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1219 → 1348
      UPA_2; UPA domain
      cl39094
      Location:426 → 650
      Ank_2; Ankyrin repeats (3 copies)

    32. XM_036162814.1 → XP_036018707.1  ankyrin-2 isoform X1

      Conserved Domains (10) summary
      smart00218
      Location:869 → 1006
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2117 → 2524
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:269 → 554
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3066 → 3393
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2614 → 2845
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3451 → 3534
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:295 → 326
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:626 → 678
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1227 → 1356
      UPA_2; UPA domain
      cl39094
      Location:426 → 650
      Ank_2; Ankyrin repeats (3 copies)

    33. XM_036162815.1 → XP_036018708.1  ankyrin-2 isoform X2

      Conserved Domains (10) summary
      smart00218
      Location:868 → 1005
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2116 → 2523
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:269 → 554
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3065 → 3392
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2613 → 2844
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3450 → 3533
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:295 → 326
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:626 → 678
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1226 → 1355
      UPA_2; UPA domain
      cl39094
      Location:426 → 650
      Ank_2; Ankyrin repeats (3 copies)

    34. XM_036162819.1 → XP_036018712.1  ankyrin-2 isoform X6

      Conserved Domains (10) summary
      smart00218
      Location:853 → 990
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2101 → 2508
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:269 → 554
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3050 → 3377
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2598 → 2829
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3435 → 3518
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:295 → 326
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:626 → 678
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1211 → 1340
      UPA_2; UPA domain
      cl39094
      Location:426 → 650
      Ank_2; Ankyrin repeats (3 copies)

    35. XM_036162816.1 → XP_036018709.1  ankyrin-2 isoform X3

      Conserved Domains (10) summary
      smart00218
      Location:865 → 1002
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2113 → 2520
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:269 → 554
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3062 → 3389
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2610 → 2841
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3447 → 3530
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:295 → 326
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:626 → 678
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1223 → 1352
      UPA_2; UPA domain
      cl39094
      Location:426 → 650
      Ank_2; Ankyrin repeats (3 copies)

    36. XM_036162821.1 → XP_036018714.1  ankyrin-2 isoform X10

      Conserved Domains (10) summary
      smart00218
      Location:873 → 977
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2088 → 2495
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:269 → 554
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3037 → 3364
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2585 → 2816
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3422 → 3505
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:295 → 326
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:626 → 678
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1198 → 1327
      UPA_2; UPA domain
      cl39094
      Location:426 → 650
      Ank_2; Ankyrin repeats (3 copies)

    37. XM_036162845.1 → XP_036018738.1  ankyrin-2 isoform X38

      Conserved Domains (11) summary
      smart00218
      Location:967 → 1104
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2215 → 2622
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:27 → 329
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3164 → 3491
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2712 → 2943
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3549 → 3632
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:422 → 453
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:720 → 772
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1325 → 1454
      UPA_2; UPA domain
      pfam12796
      Location:394 → 485
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:469 → 744
      Ank_2; Ankyrin repeats (3 copies)

    38. XM_036162833.1 → XP_036018726.1  ankyrin-2 isoform X22

      Conserved Domains (10) summary
      smart00218
      Location:1000 → 1137
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2248 → 2655
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:396 → 681
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3197 → 3524
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2745 → 2976
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3582 → 3665
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:422 → 453
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:753 → 805
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1358 → 1487
      UPA_2; UPA domain
      cl39094
      Location:553 → 777
      Ank_2; Ankyrin repeats (3 copies)

    39. XM_036162841.1 → XP_036018734.1  ankyrin-2 isoform X34

      UniProtKB/TrEMBL
      S4R2F3
      Conserved Domains (10) summary
      smart00218
      Location:975 → 1112
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2223 → 2630
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:380 → 656
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3172 → 3499
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2720 → 2951
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3557 → 3640
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:397 → 428
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:728 → 780
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1333 → 1462
      UPA_2; UPA domain
      cl39094
      Location:528 → 752
      Ank_2; Ankyrin repeats (3 copies)

    40. XM_036162848.1 → XP_036018741.1  ankyrin-2 isoform X43

      UniProtKB/TrEMBL
      S4R2F3
      Conserved Domains (11) summary
      smart00218
      Location:957 → 1094
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2205 → 2612
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:27 → 337
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3154 → 3481
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2702 → 2933
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3539 → 3622
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430 → 461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:728 → 780
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1315 → 1444
      UPA_2; UPA domain
      pfam12796
      Location:402 → 493
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:477 → 752
      Ank_2; Ankyrin repeats (3 copies)

    41. XM_036162842.1 → XP_036018735.1  ankyrin-2 isoform X35

      UniProtKB/TrEMBL
      S4R2F3
      Conserved Domains (11) summary
      smart00218
      Location:975 → 1112
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2223 → 2630
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:27 → 337
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3172 → 3499
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2720 → 2951
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3557 → 3640
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430 → 461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:728 → 780
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1333 → 1462
      UPA_2; UPA domain
      pfam12796
      Location:402 → 493
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:477 → 752
      Ank_2; Ankyrin repeats (3 copies)

    42. XM_036162830.1 → XP_036018723.1  ankyrin-2 isoform X19

      UniProtKB/TrEMBL
      S4R2F3
      Conserved Domains (10) summary
      smart00218
      Location:1008 → 1145
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2256 → 2663
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:404 → 689
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3205 → 3532
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2753 → 2984
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3590 → 3673
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430 → 461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:761 → 813
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1366 → 1495
      UPA_2; UPA domain
      cl39094
      Location:561 → 785
      Ank_2; Ankyrin repeats (3 copies)

    43. XM_036162838.1 → XP_036018731.1  ankyrin-2 isoform X31

      Conserved Domains (10) summary
      smart00218
      Location:982 → 1119
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2230 → 2637
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:396 → 681
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3179 → 3506
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2727 → 2958
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3564 → 3647
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:422 → 453
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:753 → 805
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1340 → 1469
      UPA_2; UPA domain
      cl39094
      Location:553 → 777
      Ank_2; Ankyrin repeats (3 copies)

    44. XM_017319427.2 → XP_017174916.1  ankyrin-2 isoform X24

      Conserved Domains (10) summary
      smart00218
      Location:997 → 1134
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2245 → 2652
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:411 → 696
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3194 → 3521
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2742 → 2973
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3579 → 3662
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:437 → 468
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:768 → 820
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1355 → 1484
      UPA_2; UPA domain
      cl39094
      Location:568 → 792
      Ank_2; Ankyrin repeats (3 copies)

    45. XM_036162823.1 → XP_036018716.1  ankyrin-2 isoform X12

      Conserved Domains (10) summary
      smart00218
      Location:1023 → 1160
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2271 → 2678
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:419 → 704
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3220 → 3547
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2768 → 2999
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3605 → 3688
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:445 → 476
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:776 → 828
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1381 → 1510
      UPA_2; UPA domain
      cl39094
      Location:576 → 800
      Ank_2; Ankyrin repeats (3 copies)

    46. XM_036162826.1 → XP_036018719.1  ankyrin-2 isoform X15

      Conserved Domains (10) summary
      smart00218
      Location:1015 → 1152
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2263 → 2670
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:411 → 696
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3212 → 3539
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2760 → 2991
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3597 → 3680
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:437 → 468
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:768 → 820
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1373 → 1502
      UPA_2; UPA domain
      cl39094
      Location:568 → 792
      Ank_2; Ankyrin repeats (3 copies)

    47. XM_036162855.1 → XP_036018748.1  ankyrin-2 isoform X50

      Conserved Domains (10) summary
      smart00218
      Location:1005 → 1142
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2253 → 2660
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:413 → 698
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3202 → 3529
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2750 → 2981
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3587 → 3670
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:439 → 470
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:770 → 822
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1363 → 1492
      UPA_2; UPA domain
      cl39094
      Location:570 → 794
      Ank_2; Ankyrin repeats (3 copies)

    48. XM_036162854.1 → XP_036018747.1  ankyrin-2 isoform X49

      Conserved Domains (10) summary
      smart00218
      Location:1013 → 1150
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2261 → 2668
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:421 → 706
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3210 → 3537
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2758 → 2989
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3595 → 3678
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:447 → 478
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:778 → 830
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1371 → 1500
      UPA_2; UPA domain
      cl39094
      Location:578 → 802
      Ank_2; Ankyrin repeats (3 copies)

    49. XM_036162822.1 → XP_036018715.1  ankyrin-2 isoform X11

      Conserved Domains (10) summary
      smart00218
      Location:1025 → 1162
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2273 → 2680
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:421 → 706
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3222 → 3549
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2770 → 3001
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3607 → 3690
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:447 → 478
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:778 → 830
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1383 → 1512
      UPA_2; UPA domain
      cl39094
      Location:578 → 802
      Ank_2; Ankyrin repeats (3 copies)

    50. XM_036162828.1 → XP_036018721.1  ankyrin-2 isoform X17

      Conserved Domains (10) summary
      smart00218
      Location:1013 → 1150
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00449
      Location:2261 → 2668
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:421 → 706
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:3210 → 3537
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5665
      Location:2758 → 2989
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd08804
      Location:3595 → 3678
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:447 → 478
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:778 → 830
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1371 → 1500
      UPA_2; UPA domain
      cl39094
      Location:578 → 802
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C8R3.2 GenPept UniProtKB/Swiss-Prot:Q8C8R3

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