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    Fbxo27 F-box protein 27 [ Mus musculus (house mouse) ]

    Gene ID: 233040, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Fbxo27provided by MGI
    Official Full Name
    F-box protein 27provided by MGI
    Primary source
    MGI:MGI:2685007
    See related
    Ensembl:ENSMUSG00000037463 AllianceGenome:MGI:2685007
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FBG5; Gm161; E130008B10Rik
    Summary
    Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in ERAD pathway; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and glycoprotein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in central nervous system; neural retinal epithelium; retina inner nuclear layer; retina nuclear layer; and retina outer nuclear layer. Orthologous to human FBXO27 (F-box protein 27). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 9.8), placenta adult (RPKM 8.9) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fbxo27 in Genome Data Viewer
    Location:
    7 B1; 7 16.89 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28392205..28398763)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28692780..28699338)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene microRNA 7049 Neighboring gene p21 (RAC1) activated kinase 4 Neighboring gene STARR-seq mESC enhancer starr_18428 Neighboring gene STARR-seq mESC enhancer starr_18429 Neighboring gene acid phosphatase 7, tartrate resistant Neighboring gene STARR-seq mESC enhancer starr_18430 Neighboring gene STARR-seq mESC enhancer starr_18432 Neighboring gene STARR-seq mESC enhancer starr_18434 Neighboring gene F-box protein 17 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29526699-29526882 Neighboring gene mitochondrial ribosomal protein S12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The CREG1-FBXO27-LAMP2 axis alleviates diabetic cardiomyopathy by promoting autophagy in cardiomyocytes. Liu D, et al. Exp Mol Med, 2023 Sep. PMID 37658156, Free PMC Article
    2. Systematic analysis and nomenclature of mammalian F-box proteins. Jin J, et al. Genes Dev, 2004 Nov 1. PMID 15520277, Free PMC Article
    3. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The CREG1-FBXO27-LAMP2 axis alleviates diabetic cardiomyopathy by promoting autophagy in cardiomyocytes.
      Title: The CREG1-FBXO27-LAMP2 axis alleviates diabetic cardiomyopathy by promoting autophagy in cardiomyocytes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    contributes_to ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycoprotein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SCF ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    F-box only protein 27

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163702.1 → NP_001157174.1  F-box only protein 27 isoform 1

      See identical proteins and their annotated locations for NP_001157174.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK158463, BQ033399
      Consensus CDS
      CCDS52164.1
      UniProtKB/Swiss-Prot
      Q3TYP0, Q6DIA9, Q8BKF7
      Related
      ENSMUSP00000103916.2, ENSMUST00000108281.8
      Conserved Domains (2) summary
      pfam04300
      Location:102 → 273
      FBA; F-box associated region
      pfam12937
      Location:37 → 64
      F-box-like

    2. NM_001355157.1 → NP_001342086.1  F-box only protein 27 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC109162
      Consensus CDS
      CCDS52164.1
      UniProtKB/Swiss-Prot
      Q3TYP0, Q6DIA9, Q8BKF7
      Conserved Domains (2) summary
      pfam04300
      Location:102 → 273
      FBA; F-box associated region
      pfam12937
      Location:37 → 64
      F-box-like

    3. NM_001384172.1 → NP_001371101.1  F-box only protein 27 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC109162
      Conserved Domains (2) summary
      pfam04300
      Location:125 → 298
      FBA; F-box associated region
      pfam12937
      Location:60 → 87
      F-box-like

    4. NM_207238.3 → NP_997121.1  F-box only protein 27 isoform 2

      See identical proteins and their annotated locations for NP_997121.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AK053292, BQ033399
      Consensus CDS
      CCDS21051.1
      UniProtKB/Swiss-Prot
      Q6DIA9
      Related
      ENSMUSP00000038432.5, ENSMUST00000039998.11
      Conserved Domains (2) summary
      pfam04300
      Location:104 → 274
      FBA; F-box associated region
      pfam12937
      Location:37 → 64
      F-box-like; F-box-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      28392205..28398763
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539865.4 → XP_006539928.1  F-box only protein 27 isoform X2

      Conserved Domains (2) summary
      pfam04300
      Location:168 → 299
      FBA; F-box associated region
      pfam12937
      Location:103 → 130
      F-box-like

    2. XM_006539862.4 → XP_006539925.1  F-box only protein 27 isoform X1

      Conserved Domains (2) summary
      pfam04300
      Location:168 → 339
      FBA; F-box associated region
      pfam12937
      Location:103 → 130
      F-box-like

    3. XM_006539867.5 → XP_006539930.1  F-box only protein 27 isoform X3

      See identical proteins and their annotated locations for XP_006539930.1

      UniProtKB/Swiss-Prot
      Q3TYP0, Q6DIA9, Q8BKF7
      Conserved Domains (2) summary
      pfam04300
      Location:102 → 273
      FBA; F-box associated region
      pfam12937
      Location:37 → 64
      F-box-like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6DIA9.1 GenPept UniProtKB/Swiss-Prot:Q6DIA9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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