Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cacna1aprovided by MGI
Official Full Name: calcium channel, voltage-dependent, P/Q type, alpha 1A subunitprovided by MGI
Primary source: MGI:MGI:109482
See related: Ensembl:ENSMUSG00000034656 AllianceGenome:MGI:109482
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BI; la; tg; EA2; FHM; MHP; rkr; APCA; HPCA; MHP1; SCA6; smrl; Caca1a; Cav2.1; Ccha1a; nmf352; alpha1A; Cacnl1a4
Summary: Enables high voltage-gated calcium channel activity and voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels. Acts upstream of or within several processes, including chemical synaptic transmission; modulation of chemical synaptic transmission; and nervous system development. Located in dendrite and neuronal cell body. Part of voltage-gated calcium channel complex. Is active in glutamatergic synapse; postsynaptic membrane; and presynaptic active zone membrane. Is expressed in several structures, including central nervous system; dorsal root ganglion; heart; and trigeminal nerve. Used to study Lambert-Eaton myasthenic syndrome; brain disease (multiple); and episodic ataxia type 2. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 42; hereditary ataxia (multiple); and migraine (multiple). Orthologous to human CACNA1A (calcium voltage-gated channel subunit alpha1 A). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in cerebellum adult (RPKM 34.5), cortex adult (RPKM 15.3) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C2- C3; 8 40.95 cM

Exon count:: 53

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (85065257..85366880)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (84338631..84640251)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Subcellular localization and ER-mediated cytotoxic function of alpha1A and alpha1ACT in spinocerebellar ataxia type 6.
Title: Subcellular localization and ER-mediated cytotoxic function of α1A and α1ACT in spinocerebellar ataxia type 6.
The Transcription Factor, alpha1ACT, Acts Through a MicroRNA Network to Regulate Neurogenesis and Cell Death During Neonatal Cerebellar Development.
Title: The Transcription Factor, α1ACT, Acts Through a MicroRNA Network to Regulate Neurogenesis and Cell Death During Neonatal Cerebellar Development.
Complex effects on CaV2.1 channel gating caused by a CACNA1A variant associated with a severe neurodevelopmental disorder.
Title: Complex effects on Ca(V)2.1 channel gating caused by a CACNA1A variant associated with a severe neurodevelopmental disorder.
Reversing frontal disinhibition rescues behavioural deficits in models of CACNA1A-associated neurodevelopment disorders.
Title: Reversing frontal disinhibition rescues behavioural deficits in models of CACNA1A-associated neurodevelopment disorders.
Pavlovian eyeblink conditioning is severely impaired in tottering mice.
Title: Pavlovian eyeblink conditioning is severely impaired in tottering mice.
Failed Neuroprotection of Combined Inhibition of L-Type and ASIC1a Calcium Channels with Nimodipine and Amiloride.
Title: Failed Neuroprotection of Combined Inhibition of L-Type and ASIC1a Calcium Channels with Nimodipine and Amiloride.
Adult loss of Cacna1a in mice recapitulates childhood absence epilepsy by distinct thalamic bursting mechanisms.
Title: Adult loss of Cacna1a in mice recapitulates childhood absence epilepsy by distinct thalamic bursting mechanisms.
Co-immunoprecipitations from brain tissue is consistent with the formation of a protein complex between RB-3alpha and RB-3beta and both Cav2.2 and the related Cav2.1 calcium channel.
Title: Interactions of Rabconnectin-3 with Cav2 calcium channels.
These novel findings have important implications for understanding the role of AnkB and Cav2.1 in the regulation of neuronal function in health and disease.
Title: Ankyrin B and Ankyrin B variants differentially modulate intracellular and surface Cav2.1 levels.
Facilitation of calcium entry through CaV2.1 channels makes surprisingly little contribution to synaptic facilitation under physiological conditions. Instead, CaV2.1 facilitation offsets CaV2.1 inactivation to produce remarkably stable calcium influx during high-frequency activation.
Title: The Role of Ca(V)2.1 Channel Facilitation in Synaptic Facilitation.

Submit: New GeneRIF Correction See all GeneRIFs (103)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (5) 1 citation
Endonuclease-mediated (7)
Spontaneous (8) 1 citation
Targeted (27) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH143033 (e-PCR)
- UniSTS:232280

Cacna1a (e-PCR), detects polymorphism
- UniSTS:141208

Cacna1a (e-PCR), detects polymorphism
- UniSTS:141209

Cacna1a (e-PCR), detects polymorphism
- UniSTS:141210

NoName (e-PCR)
- UniSTS:224230

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables high voltage-gated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables high voltage-gated calcium channel activity	IGI Inferred from Genetic Interaction more info	PubMed
enables high voltage-gated calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables high voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables high voltage-gated calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables syntaxin binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within adult walking behavior	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within adult walking behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within behavioral response to pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion import	ISO Inferred from Sequence Orthology more info
involved_in calcium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium ion-regulated exocytosis of neurotransmitter	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within calcium-ion regulated exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to amyloid-beta	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within central nervous system neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebellar Purkinje cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebellar Purkinje cell layer development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebellar molecular layer development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebellum maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gamma-aminobutyric acid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of hormone biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular chloride ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within membrane depolarization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within musculoskeletal movement, spinal reflex action	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of hormone biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nervous system process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuromuscular process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuromuscular process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuromuscular process controlling balance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron-neuron synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within receptor clustering	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of acetylcholine secretion, neurotransmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of calcium ion-dependent exocytosis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of hormone levels	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of presynaptic cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of sulfur amino acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to amyloid-beta	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to pain	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within rhythmic synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spinal cord motor neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
NOT acts_upstream_of_or_within synaptic transmission, GABAergic	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within transmission of nerve impulse	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vestibular nucleus development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of voltage-gated calcium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated calcium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated calcium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: voltage-dependent P/Q-type calcium channel subunit alpha-1A

Names: brain calcium channel I; calcium channel, L type, alpha-1 polypeptide; leaner; rocker; tottering; voltage-gated calcium channel subunit alpha Cav2.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252059.1 → NP_001238988.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.

Source sequence(s)

AC145556, AC164557, AK147277, AK147288, AU254963, AV375776

Consensus CDS

CCDS57628.1

UniProtKB/TrEMBL

E9Q1R5, Q3UHA5

Related

ENSMUSP00000114055.2, ENSMUST00000122053.2

Conserved Domains (6) summary

pfam00520
Location:1487 → 1726

Ion_trans; Ion transport protein

pfam01254
Location:2141 → 2200

TP2; Nuclear transition protein 2

pfam08763
Location:1799 → 1873

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam10243
Location:688 → 1001

MIP-T3; Microtubule-binding protein MIP-T3

pfam12300
Location:2224 → 2308

DUF3628; Protein of unknown function (DUF3628)

pfam16905
Location:1734 → 1797

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
NM_001252060.1 → NP_001238989.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks a segment in the 3' coding region which results in a frameshift, compared to variant 1. The resulting protein (isoform 3) has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AB066608, AC145556, AC164557, AK147288, AV375776

UniProtKB/TrEMBL

Q8R5M7

Conserved Domains (5) summary

pfam00520
Location:1534 → 1773

Ion_trans; Ion transport protein

pfam01254
Location:2188 → 2256

TP2; Nuclear transition protein 2

pfam08763
Location:1846 → 1920

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam10243
Location:735 → 1048

MIP-T3; Microtubule-binding protein MIP-T3

pfam16905
Location:1781 → 1844

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
NM_001252061.1 → NP_001238990.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 4, which has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AB066609, AC145556, AC164557, AK147288, AV375776

UniProtKB/TrEMBL

Q8R5M6

Conserved Domains (3) summary

pfam00520
Location:1534 → 1773

Ion_trans; Ion transport protein

pfam08763
Location:1846 → 1920

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1781 → 1844

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
NM_007578.3 → NP_031604.3 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform 1

See identical proteins and their annotated locations for NP_031604.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).

Source sequence(s)

AK147288, AK147498, AV375776

Consensus CDS

CCDS52618.1

UniProtKB/Swiss-Prot

P97445, Q2TPN3

UniProtKB/TrEMBL

Q3UHN4

Related

ENSMUSP00000112436.2, ENSMUST00000121390.8

Conserved Domains (6) summary

pfam00520
Location:1534 → 1773

Ion_trans; Ion transport protein

pfam01254
Location:2188 → 2247

TP2; Nuclear transition protein 2

pfam08763
Location:1846 → 1920

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam10243
Location:735 → 1048

MIP-T3; Microtubule-binding protein MIP-T3

pfam12300
Location:2271 → 2355

DUF3628; Protein of unknown function (DUF3628)

pfam16905
Location:1781 → 1844

GPHH; Voltage-dependent L-type calcium channel, IQ-associated

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

85065257..85366880

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006530609.4 → XP_006530672.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X24

See identical proteins and their annotated locations for XP_006530672.1

Conserved Domains (2) summary

PHA03247
Location:895 → 1277

PHA03247; large tegument protein UL36; Provisional

pfam00520
Location:188 → 462

Ion_trans; Ion transport protein
XM_036153733.1 → XP_036009626.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X24

Conserved Domains (2) summary

PHA03247
Location:895 → 1277

PHA03247; large tegument protein UL36; Provisional

pfam00520
Location:188 → 462

Ion_trans; Ion transport protein
XM_006530605.5 → XP_006530668.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X23

Conserved Domains (2) summary

PHA03247
Location:895 → 1277

PHA03247; large tegument protein UL36; Provisional

pfam00520
Location:1610 → 1869

Ion_trans; Ion transport protein
XM_006530587.5 → XP_006530650.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1

UniProtKB/TrEMBL

Q3UHN4

Conserved Domains (5) summary

PHA03247
Location:895 → 1277

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:2046 → 2460

PHA03307; transcriptional regulator ICP4; Provisional

pfam00520
Location:1610 → 1869

Ion_trans; Ion transport protein

pfam08763
Location:1942 → 2015

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1878 → 1931

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_011248285.4 → XP_011246587.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X19

UniProtKB/TrEMBL

Q8R5M7

Conserved Domains (5) summary

PHA03247
Location:895 → 1277

PHA03247; large tegument protein UL36; Provisional

pfam00520
Location:1610 → 1869

Ion_trans; Ion transport protein

pfam01254
Location:2284 → 2343

TP2; Nuclear transition protein 2

pfam08763
Location:1942 → 2015

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1878 → 1931

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006530603.5 → XP_006530666.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X20

UniProtKB/TrEMBL

Q8R5M7

Conserved Domains (4) summary

PHA03247
Location:895 → 1277

PHA03247; large tegument protein UL36; Provisional

pfam00520
Location:1610 → 1869

Ion_trans; Ion transport protein

pfam08763
Location:1942 → 2015

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1878 → 1931

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006530601.5 → XP_006530664.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X15

UniProtKB/TrEMBL

Q3UHN4

Conserved Domains (5) summary

PHA03247
Location:895 → 1277

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:2046 → 2448

PHA03307; transcriptional regulator ICP4; Provisional

pfam00520
Location:1610 → 1869

Ion_trans; Ion transport protein

pfam08763
Location:1942 → 2015

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1878 → 1931

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_030243261.2 → XP_030099121.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X21

UniProtKB/TrEMBL

Q8R5M7

Conserved Domains (4) summary

PHA03247
Location:895 → 1277

PHA03247; large tegument protein UL36; Provisional

pfam00520
Location:1610 → 1869

Ion_trans; Ion transport protein

pfam08763
Location:1942 → 2015

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1878 → 1931

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006530588.5 → XP_006530651.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X2

UniProtKB/TrEMBL

Q3UHN4

Conserved Domains (5) summary

PHA03247
Location:895 → 1277

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:2046 → 2460

PHA03307; transcriptional regulator ICP4; Provisional

pfam00520
Location:1610 → 1869

Ion_trans; Ion transport protein

pfam08763
Location:1942 → 2015

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1878 → 1931

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_036153732.1 → XP_036009625.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X16

UniProtKB/TrEMBL

Q3UHN4

Conserved Domains (5) summary

PHA03247
Location:895 → 1277

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:2046 → 2448

PHA03307; transcriptional regulator ICP4; Provisional

pfam00520
Location:1610 → 1869

Ion_trans; Ion transport protein

pfam08763
Location:1942 → 2015

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1878 → 1931

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_030243262.2 → XP_030099122.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X22

UniProtKB/TrEMBL

Q8R5M7

Conserved Domains (4) summary

PHA03247
Location:895 → 1277

PHA03247; large tegument protein UL36; Provisional

pfam00520
Location:1610 → 1869

Ion_trans; Ion transport protein

pfam08763
Location:1942 → 2015

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1878 → 1931

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006530592.5 → XP_006530655.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X6

UniProtKB/TrEMBL

Q3UHN4

Conserved Domains (5) summary

PHA03247
Location:895 → 1277

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:2044 → 2458

PHA03307; transcriptional regulator ICP4; Provisional

pfam00520
Location:1610 → 1867

Ion_trans; Ion transport protein

pfam08763
Location:1940 → 2013

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1876 → 1929

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006530593.5 → XP_006530656.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X7

UniProtKB/TrEMBL

Q3UHN4

Conserved Domains (5) summary

PHA03247
Location:895 → 1277

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:2044 → 2458

PHA03307; transcriptional regulator ICP4; Provisional

pfam00520
Location:1610 → 1867

Ion_trans; Ion transport protein

pfam08763
Location:1940 → 2013

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1876 → 1929

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006530602.4 → XP_006530665.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X18

UniProtKB/TrEMBL

Q3UHN4

Conserved Domains (5) summary

PHA03247
Location:895 → 1277

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:2016 → 2430

PHA03307; transcriptional regulator ICP4; Provisional

pfam00520
Location:188 → 462

Ion_trans; Ion transport protein

pfam08763
Location:1912 → 1985

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1848 → 1901

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006530595.5 → XP_006530658.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X9

UniProtKB/TrEMBL

Q3UHN4

Conserved Domains (5) summary

PHA03247
Location:895 → 1277

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:2042 → 2456

PHA03307; transcriptional regulator ICP4; Provisional

pfam00520
Location:1606 → 1865

Ion_trans; Ion transport protein

pfam08763
Location:1938 → 2011

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1874 → 1927

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006530596.5 → XP_006530659.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X10

UniProtKB/TrEMBL

Q3UHN4

Conserved Domains (5) summary

PHA03247
Location:895 → 1277

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:2042 → 2456

PHA03307; transcriptional regulator ICP4; Provisional

pfam00520
Location:1606 → 1865

Ion_trans; Ion transport protein

pfam08763
Location:1938 → 2011

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1874 → 1927

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006530598.5 → XP_006530661.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X12

UniProtKB/TrEMBL

Q3UHN4

Conserved Domains (5) summary

PHA03247
Location:895 → 1277

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:2040 → 2454

PHA03307; transcriptional regulator ICP4; Provisional

pfam00520
Location:1606 → 1863

Ion_trans; Ion transport protein

pfam08763
Location:1936 → 2009

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1872 → 1925

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006530589.5 → XP_006530652.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X3

UniProtKB/TrEMBL

Q3UHN4

Conserved Domains (5) summary

PHA03247
Location:894 → 1276

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:2045 → 2459

PHA03307; transcriptional regulator ICP4; Provisional

pfam00520
Location:1609 → 1868

Ion_trans; Ion transport protein

pfam08763
Location:1941 → 2014

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1877 → 1930

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006530591.5 → XP_006530654.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X5

UniProtKB/TrEMBL

Q3UHN4

Conserved Domains (5) summary

PHA03247
Location:893 → 1275

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:2044 → 2458

PHA03307; transcriptional regulator ICP4; Provisional

pfam00520
Location:1608 → 1867

Ion_trans; Ion transport protein

pfam08763
Location:1940 → 2013

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1876 → 1929

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006530600.5 → XP_006530663.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X14

UniProtKB/TrEMBL

Q3UHN4

Conserved Domains (5) summary

PHA03247
Location:893 → 1275

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:2038 → 2452

PHA03307; transcriptional regulator ICP4; Provisional

pfam00520
Location:1604 → 1861

Ion_trans; Ion transport protein

pfam08763
Location:1934 → 2007

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1870 → 1923

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006530590.5 → XP_006530653.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X4

UniProtKB/TrEMBL

Q3UHN4

Conserved Domains (5) summary

PHA03247
Location:894 → 1276

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:2045 → 2459

PHA03307; transcriptional regulator ICP4; Provisional

pfam00520
Location:1609 → 1868

Ion_trans; Ion transport protein

pfam08763
Location:1941 → 2014

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1877 → 1930

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006530594.5 → XP_006530657.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X8

UniProtKB/TrEMBL

Q3UHN4

Conserved Domains (5) summary

PHA03247
Location:892 → 1274

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:2043 → 2457

PHA03307; transcriptional regulator ICP4; Provisional

pfam00520
Location:1607 → 1866

Ion_trans; Ion transport protein

pfam08763
Location:1939 → 2012

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1875 → 1928

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006530599.5 → XP_006530662.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X13

UniProtKB/TrEMBL

A0A571BET0, Q3UHN4

Related

ENSMUSP00000158803.2, ENSMUST00000238701.2

Conserved Domains (5) summary

PHA03247
Location:894 → 1276

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:2039 → 2453

PHA03307; transcriptional regulator ICP4; Provisional

pfam00520
Location:1605 → 1862

Ion_trans; Ion transport protein

pfam08763
Location:1935 → 2008

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1871 → 1924

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_030243260.2 → XP_030099120.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X17

UniProtKB/TrEMBL

Q3UHN4

Conserved Domains (5) summary

PHA03247
Location:895 → 1277

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:2040 → 2442

PHA03307; transcriptional regulator ICP4; Provisional

pfam00520
Location:1606 → 1863

Ion_trans; Ion transport protein

pfam08763
Location:1936 → 2009

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1872 → 1925

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006530597.5 → XP_006530660.1 voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X11

UniProtKB/TrEMBL

Q3UHN4

Conserved Domains (5) summary

PHA03247
Location:895 → 1277

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:2040 → 2454

PHA03307; transcriptional regulator ICP4; Provisional

pfam00520
Location:1606 → 1863

Ion_trans; Ion transport protein

pfam08763
Location:1936 → 2009

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1872 → 1925

GPHH; Voltage-dependent L-type calcium channel, IQ-associated