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    Vgll3 vestigial like family member 3 [ Mus musculus (house mouse) ]

    Gene ID: 73569, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Vgll3provided by MGI
    Official Full Name
    vestigial like family member 3provided by MGI
    Primary source
    MGI:MGI:1920819
    See related
    Ensembl:ENSMUSG00000091243 AllianceGenome:MGI:1920819
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Vgl-3; Vito-2; 4832416J22; 1700110N18Rik
    Summary
    Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including genitourinary system; heart; nervous system; skeletal musculature; and trunk mesenchyme. Orthologous to human VGLL3 (vestigial like family member 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in bladder adult (RPKM 3.1), lung adult (RPKM 2.9) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Vgll3 in Genome Data Viewer
    Location:
    16 C1.3; 16 37.34 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (65612075..65663254)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (65815189..65866368)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41470 Neighboring gene G protein pathway suppressor 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_41174 Neighboring gene STARR-seq mESC enhancer starr_41175 Neighboring gene epidermal growth factor pseudogene Neighboring gene high mobility group box 1-like pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Vestigial-Like 3 Plays an Important Role in Osteoblast Differentiation by Regulating the Expression of Osteogenic Transcription Factors and BMP Signaling. Yuan H, et al. Calcif Tissue Int, 2022 Sep. PMID 35750933
    2. The female-biased factor VGLL3 drives cutaneous and systemic autoimmunity. Billi AC, et al. JCI Insight, 2019 Apr 18. PMID 30996136, Free PMC Article
    3. VGLL3 confers slow-twitch muscle differentiation via PGC-1α expression in C2C12 myocytes. Takakura Y, et al. Biochem Biophys Res Commun, 2023 Aug 20. PMID 37262950
    4. VGLL3 is a mechanosensitive protein that promotes cardiac fibrosis through liquid-liquid phase separation. Horii Y, et al. Nat Commun, 2023 Feb 8. PMID 36754961, Free PMC Article
    5. VGLL3 expression is associated with a tumor suppressor phenotype in epithelial ovarian cancer. Gambaro K, et al. Mol Oncol, 2013 Jun. PMID 23415753, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. VGLL3 confers slow-twitch muscle differentiation via PGC-1alpha expression in C2C12 myocytes.
      Title: VGLL3 confers slow-twitch muscle differentiation via PGC-1α expression in C2C12 myocytes.
    2. VGLL3 is a mechanosensitive protein that promotes cardiac fibrosis through liquid-liquid phase separation.
      Title: VGLL3 is a mechanosensitive protein that promotes cardiac fibrosis through liquid-liquid phase separation.
    3. Vestigial-Like 3 Plays an Important Role in Osteoblast Differentiation by Regulating the Expression of Osteogenic Transcription Factors and BMP Signaling.
      Title: Vestigial-Like 3 Plays an Important Role in Osteoblast Differentiation by Regulating the Expression of Osteogenic Transcription Factors and BMP Signaling.
    4. Study demonstrated that skin-directed overexpression of murine female-biased factor VGLL3 causes a severe lupus-like rash and systemic autoimmune disease that involves B cell expansion, autoantibody production, immune complex deposition, and end-organ damage. Results strongly implicate VGLL3 as a pivotal orchestrator of sex-biased autoimmunity.
      Title: The female-biased factor VGLL3 drives cutaneous and systemic autoimmunity.
    5. Loss of VGLL3 expression was observed in tumors derived from mouse xenograft models.
      Title: VGLL3 expression is associated with a tumor suppressor phenotype in epithelial ovarian cancer.
    6. vestigial-like 3 (Vgll3) is an inhibitor of adipogenesis
      Title: Vestigial-like 3 is an inhibitor of adipocyte differentiation.
    7. In embryonic and fetal development VITO-2 is mainly expressed in the myogenic lineage.Later developmental stages it is found in the nervous system.In adult mice it was detected in skeletal muscle, heart, kidney, liver, brain.
      Title: VITO-2, a new SID domain protein, is expressed in the myogenic lineage during early mouse embryonic development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transcription cofactor vestigial-like protein 3
    Names
    vestigial like 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368760.1 → NP_001355689.1  transcription cofactor vestigial-like protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      CT010565
      UniProtKB/Swiss-Prot
      P85442
      Conserved Domains (1) summary
      pfam07545
      Location:85 → 115
      Vg_Tdu; Vestigial/Tondu family

    2. NM_001368761.1 → NP_001355690.1  transcription cofactor vestigial-like protein 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      CT010565
      Consensus CDS
      CCDS88949.1
      UniProtKB/TrEMBL
      A0A2I3BPM3
      Related
      ENSMUSP00000153843.2, ENSMUST00000227997.2
      Conserved Domains (1) summary
      pfam07545
      Location:42 → 59
      Vg_Tdu; Vestigial/Tondu family

    3. NM_028572.2 → NP_082848.1  transcription cofactor vestigial-like protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT010565
      Consensus CDS
      CCDS49884.1
      UniProtKB/TrEMBL
      E9Q1Y1
      Related
      ENSMUSP00000131500.2, ENSMUST00000168064.3
      Conserved Domains (1) summary
      pfam07545
      Location:84 → 114
      Vg_Tdu; Vestigial/Tondu family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      65612075..65663254
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P85442.1 GenPept UniProtKB/Swiss-Prot:P85442

    Gene LinkOut

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