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    SLC27A6 solute carrier family 27 member 6 [ Homo sapiens (human) ]

    Gene ID: 28965, updated on 9-Dec-2024

    Summary

    Official Symbol
    SLC27A6provided by HGNC
    Official Full Name
    solute carrier family 27 member 6provided by HGNC
    Primary source
    HGNC:HGNC:11000
    See related
    Ensembl:ENSG00000113396 MIM:604196; AllianceGenome:HGNC:11000
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FATP6; ACSVL2; FACVL2; VLCS-H1
    Summary
    This gene encodes a member of the fatty acid transport protein family (FATP). FATPs are involved in the uptake of long-chain fatty acids and have unique expression patterns. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in adrenal (RPKM 12.7), heart (RPKM 7.8) and 8 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See SLC27A6 in Genome Data Viewer
    Location:
    5q23.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (128965488..129033635)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (129484343..129552406)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (128301181..128369328)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379167 Neighboring gene uncharacterized LOC105379168 Neighboring gene NANOG hESC enhancer GRCh37_chr5:128006634-128007158 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16297 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:128205611-128206165 Neighboring gene MPRA-validated peak5459 silencer Neighboring gene uncharacterized LOC102723638 Neighboring gene uncharacterized LOC124901060 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16298 Neighboring gene isochorismatase domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of solute carrier family 27 (fatty acid transporter), member 6 (SLC27A6) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp779M0564

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables arachidonate-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables fatty acid transmembrane transporter activity TAS
    Traceable Author Statement
    more info
     
    enables long-chain fatty acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables long-chain fatty acid-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oleate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables very long-chain fatty acid-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in long-chain fatty acid import into cell IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in long-chain fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in long-chain fatty acid transport TAS
    Traceable Author Statement
    more info
     
    involved_in very long-chain fatty acid metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in sarcolemma IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    long-chain fatty acid transport protein 6
    Names
    acyl-CoA synthetase very long chain family, member 2
    arachidonate--CoA ligase
    fatty-acid-Coenzyme A ligase, very long-chain 2
    long-chain-fatty-acid--CoA ligase
    solute carrier family 27 (fatty acid transporter), member 6
    very long-chain acyl-CoA synthetase homolog 1
    NP_001017372.1
    NP_001304913.1
    NP_054750.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017372.3NP_001017372.1  long-chain fatty acid transport protein 6

      See identical proteins and their annotated locations for NP_001017372.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an additional segment in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AA614135, AC004636, AF064254, AL833117, BX537383
      Consensus CDS
      CCDS4145.1
      UniProtKB/Swiss-Prot
      Q6IAM5, Q7Z6E6, Q86YF6, Q9Y2P4
      UniProtKB/TrEMBL
      B2R8P6
      Related
      ENSP00000262462.4, ENST00000262462.9
      Conserved Domains (2) summary
      cd05938
      Location:77609
      hsFATP2a_ACSVL_like; Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar proteins
      PRK08279
      Location:16619
      PRK08279; long-chain-acyl-CoA synthetase; Validated
    2. NM_001317984.2NP_001304913.1  long-chain fatty acid transport protein 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses two alternate splice sites in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AA614135, AC004636, AF064254, AK313456, BX537383
      Consensus CDS
      CCDS4145.1
      UniProtKB/Swiss-Prot
      Q6IAM5, Q7Z6E6, Q86YF6, Q9Y2P4
      UniProtKB/TrEMBL
      B2R8P6
      Related
      ENSP00000421024.1, ENST00000506176.1
      Conserved Domains (2) summary
      cd05938
      Location:77609
      hsFATP2a_ACSVL_like; Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar proteins
      PRK08279
      Location:16619
      PRK08279; long-chain-acyl-CoA synthetase; Validated
    3. NM_014031.5NP_054750.1  long-chain fatty acid transport protein 6

      See identical proteins and their annotated locations for NP_054750.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the same protein as variants 2 and 3.
      Source sequence(s)
      AA614135, AC004636, AF064254, BX537383
      Consensus CDS
      CCDS4145.1
      UniProtKB/Swiss-Prot
      Q6IAM5, Q7Z6E6, Q86YF6, Q9Y2P4
      UniProtKB/TrEMBL
      B2R8P6
      Related
      ENSP00000378684.1, ENST00000395266.5
      Conserved Domains (2) summary
      cd05938
      Location:77609
      hsFATP2a_ACSVL_like; Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar proteins
      PRK08279
      Location:16619
      PRK08279; long-chain-acyl-CoA synthetase; Validated

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      128965488..129033635
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      129484343..129552406
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)