Eras ES cell-expressed Ras [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Erasprovided by MGI
Official Full Name: ES cell-expressed Rasprovided by MGI
Primary source: MGI:MGI:2665023
See related: Ensembl:ENSMUSG00000031160 AllianceGenome:MGI:2665023
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HRAS2; HRasp; ecat5; Ha-Ras2
Summary: Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in Ras protein signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including blastocyst; early embryo; embryo ectoderm; embryo mesoderm; and primitive streak. Orthologous to human ERAS (ES cell expressed Ras). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 83.1), cerebellum adult (RPKM 64.9) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A1.1; X 3.58 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (7790515..7794846, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (7924276..7928607, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ERAS may also play important roles in cell lineage specification during mouse early embryonic development.
Title: The roles of ERAS during cell lineage specification of mouse early embryonic development.
Collectively, these results unravel the significance of the ERas-Akt-FoxO1 signaling axis in iPSC generation, suggesting a possibly shared molecular basis for both somatic reprogramming and cancer initiation
Title: Stimulation of somatic cell reprogramming by ERas-Akt-FoxO1 signaling axis.
galectin-1 increased DNA synthesis in mouse ES cells via Src, caveolin-1 Akt, and mTOR signaling pathways
Title: Interaction of galectin-1 with caveolae induces mouse embryonic stem cell proliferation through the Src, ERas, Akt and mTOR signaling pathways.
rasH2 may have a role in susceptibility to chemically-induced tongue and esophageal neoplasms
Title: A novel rasH2 mouse carcinogenesis model that is highly susceptible to 4-NQO-induced tongue and esophageal carcinogenesis is useful for preclinical chemoprevention studies.
ERas and Rheb are two Ras-related proteins involved in the phosphatidylinositol 3-kinase/mTOR pathway; ERas is localized at the plasma membrane, while Rheb is on endomembranes.
Title: Differential membrane localization of ERas and Rheb, two Ras-related proteins involved in the phosphatidylinositol 3-kinase/mTOR pathway.
transforming oncogene ERas is important in the tumour-like growth properties of embryonic stem cells
Title: Role of ERas in promoting tumour-like properties in mouse embryonic stem cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

General gene information

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Markers

AF006603 (e-PCR)
- UniSTS:186168

NoName (e-PCR)
- UniSTS:494943

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GDP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: GTPase ERas

Names: E-Ras; embryonic stem cell-expressed Ras; small GTPase E-Ras

NP_853526.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181548.2 → NP_853526.1 GTPase ERas

See identical proteins and their annotated locations for NP_853526.1

Status: PROVISIONAL

Source sequence(s)

AB093573

Consensus CDS

CCDS29980.1

UniProtKB/Swiss-Prot

Q7TN89

UniProtKB/TrEMBL

Q0VEC9

Related

ENSMUSP00000033500.5, ENSMUST00000033500.5

Conserved Domains (2) summary

smart00010
Location:40 → 201

small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily

cl21455
Location:42 → 201

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases