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    OR10J1 olfactory receptor family 10 subfamily J member 1 [ Homo sapiens (human) ]

    Gene ID: 26476, updated on 10-Dec-2024

    Summary

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    Official Symbol
    OR10J1provided by HGNC
    Official Full Name
    olfactory receptor family 10 subfamily J member 1provided by HGNC
    Primary source
    HGNC:HGNC:8175
    See related
    Ensembl:ENSG00000196184 AllianceGenome:HGNC:8175
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HGMP07J; HSHGMP07J
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward testis (RPKM 1.9) See more
    Orthologs
    all
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    Genomic context

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    See OR10J1 in Genome Data Viewer
    Location:
    1q23.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (159397465..159440967)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (158534496..158578008)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (159367255..159410757)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904433 Neighboring gene olfactory receptor family 10 subfamily J member 7 pseudogene Neighboring gene olfactory receptor family 10 subfamily J member 8 pseudogene Neighboring gene olfactory receptor family 10 subfamily J member 9 pseudogene Neighboring gene Sharpr-MPRA regulatory region 7346 Neighboring gene olfactory receptor family 10 subfamily J member 4 (gene/pseudogene) Neighboring gene long intergenic non-protein coding RNA 2819 Neighboring gene olfactory receptor family 10 subfamily J member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Chemerin, a novel adipokine in the regulation of angiogenesis. Bozaoglu K, et al. J Clin Endocrinol Metab, 2010 May. PMID 20237162, Free PMC Article
    2. Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women. Reiner AP, et al. Am J Hum Genet, 2012 Sep 7. PMID 22939635, Free PMC Article
    3. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. Yang Q, et al. BMC Med Genet, 2007 Sep 19. PMID 17903294, Free PMC Article
    4. Genome-wide association with select biomarker traits in the Framingham Heart Study. Benjamin EJ, et al. BMC Med Genet, 2007 Sep 19. PMID 17903293, Free PMC Article
    5. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. Parmentier M, et al. Nature, 1992 Jan 30. PMID 1370859

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Chemerin, a novel adipokine in the regulation of angiogenesis.
    EBI GWAS Catalog
    Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study.
    EBI GWAS Catalog
    Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.
    EBI GWAS Catalog
    Genome-wide association with select biomarker traits in the Framingham Heart Study.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC138495, MGC138497

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables odorant binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of smell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory perception of chemical stimulus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in single fertilization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    olfactory receptor 10J1
    Names
    olfactory receptor OR1-26
    olfactory receptor-like protein HGMP07J

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363557.2 → NP_001350486.1  olfactory receptor 10J1

      Status: VALIDATED

      Source sequence(s)
      AL513323, AL663023
      Consensus CDS
      CCDS86023.1
      UniProtKB/Swiss-Prot
      P30954, Q2M1M8, Q5VSV1, Q6IET5, Q96R56
      UniProtKB/TrEMBL
      A0A126GWQ9
      Conserved Domains (1) summary
      cd15225
      Location:25 → 300
      7tmA_OR10A-like; olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001363558.2 → NP_001350487.1  olfactory receptor 10J1

      Status: VALIDATED

      Source sequence(s)
      AL513323, AL663023
      Consensus CDS
      CCDS86023.1
      UniProtKB/Swiss-Prot
      P30954, Q2M1M8, Q5VSV1, Q6IET5, Q96R56
      UniProtKB/TrEMBL
      A0A126GWQ9
      Conserved Domains (1) summary
      cd15225
      Location:25 → 300
      7tmA_OR10A-like; olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. NM_012351.3 → NP_036483.3  olfactory receptor 10J1

      Status: VALIDATED

      Source sequence(s)
      AL663023, BC069150
      Consensus CDS
      CCDS86023.1
      UniProtKB/Swiss-Prot
      P30954, Q2M1M8, Q5VSV1, Q6IET5, Q96R56
      UniProtKB/TrEMBL
      A0A126GWQ9
      Related
      ENSP00000399078.4, ENST00000423932.6
      Conserved Domains (1) summary
      cd15225
      Location:25 → 300
      7tmA_OR10A-like; olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      159397465..159440967
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047417793.1 → XP_047273749.1  olfactory receptor 10J1 isoform X1

      UniProtKB/Swiss-Prot
      P30954, Q2M1M8, Q5VSV1, Q6IET5, Q96R56
      UniProtKB/TrEMBL
      A0A126GWQ9
      Related
      ENSP00000493228.1, ENST00000642080.1

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791759.1 Reference GRCh38.p14 PATCHES

      Range
      149291..192794
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332857.1 → XP_054188832.1  olfactory receptor 10J1 isoform X1

      UniProtKB/Swiss-Prot
      P30954, Q2M1M8, Q5VSV1, Q6IET5, Q96R56
      UniProtKB/TrEMBL
      A0A126GWQ9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      158534496..158578008
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054335967.1 → XP_054191942.1  olfactory receptor 10J1 isoform X1

      UniProtKB/Swiss-Prot
      P30954, Q2M1M8, Q5VSV1, Q6IET5, Q96R56
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30954.2 GenPept UniProtKB/Swiss-Prot:P30954

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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