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    btk Bruton agammaglobulinemia tyrosine kinase [ Danio rerio (zebrafish) ]

    Gene ID: 568653, updated on 9-Dec-2024

    Summary

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    Official Symbol
    btkprovided by ZNC
    Official Full Name
    Bruton agammaglobulinemia tyrosine kinaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070531-1
    See related
    Ensembl:ENSDARG00000004433 AllianceGenome:ZFIN:ZDB-GENE-070531-1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable non-membrane spanning protein tyrosine kinase activity. Acts upstream of or within anterior/posterior pattern specification; negative regulation of Wnt signaling pathway; and regulation of canonical Wnt signaling pathway. Predicted to be located in cytosol. Predicted to be active in plasma membrane. Is expressed in hematopoietic system. Human ortholog(s) of this gene implicated in agammaglobulinemia (multiple); isolated growth hormone deficiency type III; and lymphoma (multiple). Orthologous to human BTK (Bruton tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See btk in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (38892033..38929894, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (38551406..38589641, complement)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene zgc:101583 Neighboring gene translocase of inner mitochondrial membrane 8 homolog A (yeast) Neighboring gene galactosidase, alpha Neighboring gene glycine receptor, alpha 4a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A network-based approach to identify deregulated pathways and drug effects in metabolic syndrome. Misselbeck K, et al. Nat Commun, 2019 Nov 18. PMID 31740673, Free PMC Article
    2. Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling. James RG, et al. Sci Signal, 2009 May 26. PMID 19471023, Free PMC Article
    3. The Bruton's Tyrosine Kinase Inhibitor Ibrutinib Impairs the Vascular Development of Zebrafish Larvae. Wang K, et al. Front Pharmacol, 2020. PMID 33519491, Free PMC Article
    4. Bacterial Quorum-Sensing Signal DSF Inhibits LPS-Induced Inflammations by Suppressing Toll-like Receptor Signaling and Preventing Lysosome-Mediated Apoptosis in Zebrafish. Zhu H, et al. Int J Mol Sci, 2022 Jun 26. PMID 35806111, Free PMC Article
    5. Individual knock out of glycine receptor alpha subunits identifies a specific requirement of glra1 for motor function in zebrafish. Samarut E, et al. PLoS One, 2019. PMID 31048868, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in B cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adaptive immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within anterior/posterior pattern specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine-protein kinase BTK
    XP_021336920.1
    XP_068074880.1
    XP_697087.5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      38892033..38929894 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021481245.2 → XP_021336920.1  tyrosine-protein kinase BTK

      UniProtKB/TrEMBL
      A0A8M9QPK4, F8W3B7
      Related
      ENSDARP00000124430.1, ENSDART00000148737.3
      Conserved Domains (4) summary
      cd01238
      Location:6 → 145
      PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
      cl15255
      Location:252 → 357
      SH2; Src homology 2 (SH2) domain
      cl17036
      Location:195 → 249
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:376 → 630
      PKc_like; Protein Kinases, catalytic domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394925.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      160824..197092 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_691995.9 → XP_697087.5  tyrosine-protein kinase BTK

      UniProtKB/TrEMBL
      A0A8N7UW23
      Conserved Domains (4) summary
      cd01238
      Location:6 → 145
      PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
      cl15255
      Location:252 → 357
      SH2; Src homology 2 (SH2) domain
      cl17036
      Location:195 → 249
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:376 → 630
      PKc_like; Protein Kinases, catalytic domain

    2. XM_068218779.1 → XP_068074880.1  tyrosine-protein kinase BTK

      UniProtKB/TrEMBL
      A0A8N7UW23
    Nucleotide Protein
    Heading Accession and Version

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