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    mylka myosin, light chain kinase a [ Danio rerio (zebrafish) ]

    Gene ID: 569510, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mylkaprovided by ZNC
    Official Full Name
    myosin, light chain kinase aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8207
    See related
    AllianceGenome:ZFIN:ZDB-GENE-030131-8207
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    mylk; mlck1a; smMLCK; zmlck1; fj60a06; wu:fj60a06
    Summary
    Predicted to enable protein kinase activity. Acts upstream of or within blood coagulation and regulation of cell motility. Is expressed in bulbus arteriosus; eye; gut; and sinus venosus. Human ortholog(s) of this gene implicated in adult respiratory distress syndrome; asthma; coronary artery disease; megacystis-microcolon-intestinal hypoperistalsis syndrome; and thoracic aortic aneurysm. Orthologous to human MYLK (myosin light chain kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mylka in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (4024250..4145633, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (4055593..4177096, complement)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene myosin IIIB Neighboring gene ubiquitin protein ligase E3 component n-recognin 3 Neighboring gene kalirin RhoGEF kinase a Neighboring gene transfer RNA proline (anticodon CGG)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A Novel Long Non-coding RNA, durga Modulates Dendrite Density and Expression of kalirin in Zebrafish. Sarangdhar MA, et al. Front Mol Neurosci, 2017. PMID 28442991, Free PMC Article
    2. Identification and regulation of a molecular module for bleb-based cell motility. Goudarzi M, et al. Dev Cell, 2012 Jul 17. PMID 22705393
    3. Mlck1a is expressed in zebrafish thrombocytes and is an essential component of thrombus formation. Tournoij E, et al. J Thromb Haemost, 2010 Mar. PMID 20002541, Free PMC Article
    4. A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart. Seguchi O, et al. J Clin Invest, 2007 Oct. PMID 17885681, Free PMC Article
    5. Migration of zebrafish primordial germ cells: a role for myosin contraction and cytoplasmic flow. Blaser H, et al. Dev Cell, 2006 Nov. PMID 17084355

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Conclude that Mlck1a is the subtype of MLCK that contributes to platelet shape change and thrombus formation.
      Title: Mlck1a is expressed in zebrafish thrombocytes and is an essential component of thrombus formation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin light chain kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blood coagulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle structure development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cell motility IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    myosin light chain kinase, smooth muscle
    Names
    kinase related protein, telokin
    myosin light chain kinase 1
    smooth muscle MLCK
    XP_009302720.1
    XP_009302721.1
    XP_017213228.1
    XP_068079634.1
    XP_068079635.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      4024250..4145633 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017357739.2 → XP_017213228.1  myosin light chain kinase, smooth muscle isoform X3

      UniProtKB/TrEMBL
      A0A8M6Z0Z3

    2. XM_009304446.2 → XP_009302721.1  myosin light chain kinase, smooth muscle isoform X2

      UniProtKB/TrEMBL
      A0A8M3AVR0
      Conserved Domains (9) summary
      cd00096
      Location:678 → 747
      Ig; Immunoglobulin domain
      cd05762
      Location:1199 → 1296
      Ig8_MLCK; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK)
      PHA03255
      Location:283 → 461
      PHA03255; BDLF3; Provisional
      smart00408
      Location:1768 → 1835
      IGc2; Immunoglobulin C-2 Type
      cd00063
      Location:1292 → 1381
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1755 → 1845
      I-set; Immunoglobulin I-set domain
      cd14191
      Location:1423 → 1681
      STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
      pfam00069
      Location:1426 → 1681
      Pkinase; Protein kinase domain
      cl11960
      Location:91 → 165
      Ig; Immunoglobulin domain

    3. XM_009304445.2 → XP_009302720.1  myosin light chain kinase, smooth muscle isoform X1

      UniProtKB/TrEMBL
      A0A8M3BC88
      Conserved Domains (9) summary
      cd00096
      Location:678 → 747
      Ig; Immunoglobulin domain
      cd05762
      Location:1199 → 1296
      Ig8_MLCK; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK)
      PHA03255
      Location:283 → 461
      PHA03255; BDLF3; Provisional
      smart00408
      Location:1769 → 1836
      IGc2; Immunoglobulin C-2 Type
      cd00063
      Location:1292 → 1381
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1756 → 1846
      I-set; Immunoglobulin I-set domain
      cd14191
      Location:1423 → 1681
      STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
      pfam00069
      Location:1426 → 1681
      Pkinase; Protein kinase domain
      cl11960
      Location:91 → 165
      Ig; Immunoglobulin domain

    4. XM_068223534.1 → XP_068079635.1  myosin light chain kinase, smooth muscle isoform X4

    5. XM_068223533.1 → XP_068079634.1  myosin light chain kinase, smooth muscle isoform X4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001105682.1: Suppressed sequence

      Description
      NM_001105682.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from chicken: MYLK (GeneID:396445).
    Nucleotide Protein
    Heading Accession and Version

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