U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    rasgrp3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) [ Danio rerio (zebrafish) ]

    Gene ID: 563441, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    rasgrp3provided by ZNC
    Official Full Name
    RAS guanyl releasing protein 3 (calcium and DAG-regulated)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070424-82
    See related
    Ensembl:ENSDARG00000077864 AllianceGenome:ZFIN:ZDB-GENE-070424-82
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:162151
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to act upstream of or within small GTPase-mediated signal transduction. Predicted to be active in plasma membrane. Is expressed in blood island; central nervous system; and trunk vasculature. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human RASGRP3 (RAS guanyl releasing protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See rasgrp3 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (23122308..23205070)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (23102201..23181280)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 27 Neighboring gene microRNA 456 Neighboring gene latent transforming growth factor beta binding protein 1 Neighboring gene si:ch211-195b21.5 Neighboring gene family with sequence similarity 98 member A

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Yolk sac-derived Pdcd11-positive cells modulate zebrafish microglia differentiation through the NF-κB-Tgfβ1 pathway. Yang R, et al. Cell Death Differ, 2021 Jan. PMID 32709934, Free PMC Article
    2. A screen for hoxb1-regulated genes identifies ppp1r14al as a regulator of the rhombomere 4 Fgf-signaling center. Choe SK, et al. Dev Biol, 2011 Oct 15. PMID 21787765, Free PMC Article
    3. Discovery and characterization of novel vascular and hematopoietic genes downstream of etsrp in zebrafish. Gomez GA, et al. PLoS One, 2009. PMID 19308258, Free PMC Article
    4. Identification of vascular and hematopoietic genes downstream of etsrp by deep sequencing in zebrafish. Gomez G, et al. PLoS One, 2012. PMID 22438865, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    ras guanyl-releasing protein 3

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110464.1 → NP_001103934.1  ras guanyl-releasing protein 3

      See identical proteins and their annotated locations for NP_001103934.1

      Status: PROVISIONAL

      Source sequence(s)
      BC139527
      UniProtKB/TrEMBL
      A4QNU6
      Related
      ENSDARP00000101181.2, ENSDART00000114212.3
      Conserved Domains (5) summary
      cd06224
      Location:11 → 102
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      smart00147
      Location:148 → 384
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00029
      Location:495 → 544
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:428 → 476
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:428 → 478
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      23122308..23205070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005158517.5 → XP_005158574.1  ras guanyl-releasing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_005158574.1

      UniProtKB/TrEMBL
      A0A8M2B4V9, F1QFI3
      Conserved Domains (5) summary
      cd06224
      Location:11 → 102
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      smart00147
      Location:148 → 384
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00029
      Location:495 → 544
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:428 → 476
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:428 → 478
      EF-hand_7; EF-hand domain pair

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394988.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      172524..228866
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395330.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      46868..101126
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous