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    itsn2a intersectin 2a [ Danio rerio (zebrafish) ]

    Gene ID: 566412, updated on 9-Dec-2024

    Summary

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    Official Symbol
    itsn2aprovided by ZNC
    Official Full Name
    intersectin 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041014-84
    See related
    Ensembl:ENSDARG00000000161 AllianceGenome:ZFIN:ZDB-GENE-041014-84
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-266k12.1
    Summary
    Predicted to enable molecular adaptor activity. Predicted to be involved in clathrin-dependent synaptic vesicle endocytosis. Predicted to act upstream of or within intracellular signal transduction. Predicted to be located in cell projection and synapse. Predicted to be active in cytoplasm; intracellular vesicle; and presynaptic membrane. Orthologous to human ITSN2 (intersectin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See itsn2a in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (25356923..25436351, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (25459860..25537263, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene cellular communication network factor 2a Neighboring gene family with sequence similarity 228 member A Neighboring gene mitochondrial ribosomal protein L19 Neighboring gene phosphoribosylformylglycinamidine synthase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
    2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    intersectin-2a
    Names
    DKEY-266K12.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001144800.1 → NP_001138272.1  intersectin-2a

      See identical proteins and their annotated locations for NP_001138272.1

      Status: PROVISIONAL

      Source sequence(s)
      CR792450
      UniProtKB/TrEMBL
      B0V162
      Related
      ENSDARP00000062779.6, ENSDART00000062780.7
      Conserved Domains (12) summary
      cd08375
      Location:1523 → 1657
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:7 → 92
      EH; Eps15 homology domain
      cd11838
      Location:959 → 1010
      SH3_Intersectin_3; Third Src homology 3 domain (or SH3C) of Intersectin
      cd11988
      Location:759 → 815
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11994
      Location:1027 → 1085
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd00052
      Location:19 → 83
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam00169
      Location:1405 → 1511
      PH; PH domain
      pfam00621
      Location:1184 → 1364
      RhoGEF; RhoGEF domain
      pfam13499
      Location:226 → 283
      EF-hand_7; EF-hand domain pair
      cl17036
      Location:1100 → 1153
      SH3; Src Homology 3 domain superfamily
      cl17171
      Location:1391 → 1519
      PH-like; Pleckstrin homology-like domain
      cl23720
      Location:467 → 595
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      25356923..25436351 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009300809.4 → XP_009299084.1  intersectin-2a isoform X2

      UniProtKB/TrEMBL
      A0A8M3AZ10, U3JA74
      Related
      ENSDARP00000127139.1, ENSDART00000153266.2
      Conserved Domains (12) summary
      cd08375
      Location:1497 → 1631
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:7 → 92
      EH; Eps15 homology domain
      cd11838
      Location:933 → 984
      SH3_Intersectin_3; Third Src homology 3 domain (or SH3C) of Intersectin
      cd11988
      Location:749 → 805
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11994
      Location:1001 → 1059
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd00052
      Location:19 → 83
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam00169
      Location:1379 → 1485
      PH; PH domain
      pfam00621
      Location:1158 → 1338
      RhoGEF; RhoGEF domain
      pfam13499
      Location:226 → 283
      EF-hand_7; EF-hand domain pair
      cl17036
      Location:1074 → 1127
      SH3; Src Homology 3 domain superfamily
      cl17171
      Location:1365 → 1493
      PH-like; Pleckstrin homology-like domain
      cl23720
      Location:457 → 585
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    2. XM_021468487.2 → XP_021324162.1  intersectin-2a isoform X1

      UniProtKB/TrEMBL
      A0A8M9PBV5
      Conserved Domains (9) summary
      cd08375
      Location:1524 → 1658
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:7 → 92
      EH; Eps15 homology domain
      cd11838
      Location:960 → 1011
      SH3_Intersectin_3; Third Src homology 3 domain (or SH3C) of Intersectin
      cd11988
      Location:776 → 832
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11994
      Location:1028 → 1086
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd00160
      Location:1181 → 1364
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam16652
      Location:1383 → 1523
      PH_13; Pleckstrin homology domain
      cl17036
      Location:1101 → 1154
      SH3; Src Homology 3 domain superfamily
      cl25732
      Location:453 → 727
      SMC_N; RecF/RecN/SMC N terminal domain

    3. XM_021468488.2 → XP_021324163.1  intersectin-2a isoform X1

      UniProtKB/TrEMBL
      A0A8M9PBV5
      Conserved Domains (9) summary
      cd08375
      Location:1524 → 1658
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:7 → 92
      EH; Eps15 homology domain
      cd11838
      Location:960 → 1011
      SH3_Intersectin_3; Third Src homology 3 domain (or SH3C) of Intersectin
      cd11988
      Location:776 → 832
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11994
      Location:1028 → 1086
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd00160
      Location:1181 → 1364
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam16652
      Location:1383 → 1523
      PH_13; Pleckstrin homology domain
      cl17036
      Location:1101 → 1154
      SH3; Src Homology 3 domain superfamily
      cl25732
      Location:453 → 727
      SMC_N; RecF/RecN/SMC N terminal domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395073.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      228156..281304 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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