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    pabpc4 poly(A) binding protein, cytoplasmic 4 (inducible form) [ Danio rerio (zebrafish) ]

    Gene ID: 321035, updated on 2-Nov-2024

    Summary

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    Official Symbol
    pabpc4provided by ZNC
    Official Full Name
    poly(A) binding protein, cytoplasmic 4 (inducible form)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9663
    See related
    Ensembl:ENSDARG00000059259 AllianceGenome:ZFIN:ZDB-GENE-030131-9663
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb12; sb:cb12
    Summary
    Predicted to enable mRNA 3'-UTR binding activity; poly(A) binding activity; and poly(U) RNA binding activity. Predicted to be located in cytoplasm. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasmic stress granule; cytosol; and nucleus. Is expressed in eye; musculature system; solid lens vesicle; and somite. Orthologous to several human genes including PABPC4 (poly(A) binding protein cytoplasmic 4). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See pabpc4 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (25305584..25326690, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (25287183..25308365, complement)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene kelch repeat and BTB domain containing 11 Neighboring gene peptidylprolyl isomerase E (cyclophilin E) Neighboring gene zona pellucida protein C Neighboring gene transmembrane protein 54a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Poly(A)-binding proteins are required for microRNA-mediated silencing and to promote target deadenylation in C. elegans. Flamand MN, et al. Nucleic Acids Res, 2016 Jul 8. PMID 27095199, Free PMC Article
    2. Translational inhibition by deadenylation-independent mechanisms is central to microRNA-mediated silencing in zebrafish. Mishima Y, et al. Proc Natl Acad Sci U S A, 2012 Jan 24. PMID 22232654, Free PMC Article
    3. Reconstruction of a 450-My-old ancestral vertebrate protokaryotype. Kohn M, et al. Trends Genet, 2006 Apr. PMID 16517001
    4. Spatiotemporal compartmentalization of key physiological processes during muscle precursor differentiation. Ozbudak EM, et al. Proc Natl Acad Sci U S A, 2010 Mar 2. PMID 20160088, Free PMC Article
    5. An evolutionary approach to recover genes predominantly expressed in the testes of the zebrafish, chicken and mouse. Fouchécourt S, et al. BMC Evol Biol, 2019 Jul 3. PMID 31269894, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(U) RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    polyadenylate-binding protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201296.1 → NP_958453.1  polyadenylate-binding protein 4

      See identical proteins and their annotated locations for NP_958453.1

      Status: PROVISIONAL

      Source sequence(s)
      BC053126
      UniProtKB/TrEMBL
      A0A8M1PJ34, Q7T3G5
      Related
      ENSDARP00000140050.1, ENSDART00000168822.3
      Conserved Domains (6) summary
      TIGR01628
      Location:12 → 614
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12378
      Location:13 → 92
      RRM1_I_PABPs; RNA recognition motif 1 in type I polyadenylate-binding proteins
      cd12379
      Location:98 → 173
      RRM2_I_PABPs; RNA recognition motif 2 found in type I polyadenylate-binding proteins
      cd12380
      Location:191 → 270
      RRM3_I_PABPs; RNA recognition motif 3 found in type I polyadenylate-binding proteins
      cd12381
      Location:294 → 371
      RRM4_I_PABPs; RNA recognition motif 4 in type I polyadenylate-binding proteins
      pfam00658
      Location:546 → 613
      PABP; Poly-adenylate binding protein, unique domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      25305584..25326690 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021467109.2 → XP_021322784.1  polyadenylate-binding protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PE33
      Conserved Domains (1) summary
      TIGR01628
      Location:12 → 609
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394991.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      232507..253257 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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