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    rad51b RAD51 paralog B [ Danio rerio (zebrafish) ]

    Gene ID: 406721, updated on 2-Nov-2024

    Summary

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    Official Symbol
    rad51bprovided by ZNC
    Official Full Name
    RAD51 paralog Bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2750
    See related
    Ensembl:ENSDARG00000037046 AllianceGenome:ZFIN:ZDB-GENE-040426-2750
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    rad51l1; zgc:56581; wu:fd07f04
    Summary
    Predicted to enable ATP-dependent activity, acting on DNA; double-stranded DNA binding activity; and single-stranded DNA binding activity. Predicted to contribute to four-way junction DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination. Predicted to act upstream of or within DNA repair. Predicted to be located in nucleus. Predicted to be part of Rad51B-Rad51C-Rad51D-XRCC2 complex. Predicted to be active in replication fork. Is expressed in head. Orthologous to human RAD51B (RAD51 paralog B). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See rad51b in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (9474878..9566859)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (9487231..9579619)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene retinol dehydrogenase 14b Neighboring gene cysteine-rich protein 2-like Neighboring gene zinc finger protein 36, C3H type-like 1b Neighboring gene nidogen 2b (osteonidogen)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Loss of the homologous recombination gene rad51 leads to Fanconi anemia-like symptoms in zebrafish. Botthof JG, et al. Proc Natl Acad Sci U S A, 2017 May 30. PMID 28512217, Free PMC Article
    2. Toxicity and Transcriptome Sequencing (RNA-seq) Analyses of Adult Zebrafish in Response to Exposure Carboxymethyl Cellulose Stabilized Iron Sulfide Nanoparticles. Zheng M, et al. Sci Rep, 2018 May 24. PMID 29795396, Free PMC Article
    3. Zebrafish Establish Female Germ Cell Identity by Advancing Cell Proliferation and Meiosis. Pan YJ, et al. Front Cell Dev Biol, 2022. PMID 35445010, Free PMC Article
    4. Cellular responses to ionizing radiation change quickly over time during early development in zebrafish. Honjo Y, et al. Cell Biol Int, 2019 May. PMID 30791195, Free PMC Article
    5. E2f5 is a versatile transcriptional activator required for spermatogenesis and multiciliated cell differentiation in zebrafish. Xie H, et al. PLoS Genet, 2020 Mar. PMID 32196499, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent DNA damage sensor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent activity, acting on DNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to four-way junction DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within double-strand break repair via homologous recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Rad51B-Rad51C-Rad51D-XRCC2 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in replication fork IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA repair protein RAD51 homolog 2
    Names
    DKEYP-88E3.2
    RAD51 homolog B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213412.1 → NP_998577.1  DNA repair protein RAD51 homolog 2

      See identical proteins and their annotated locations for NP_998577.1

      Status: PROVISIONAL

      Source sequence(s)
      BC052122
      UniProtKB/TrEMBL
      Q7ZTX4
      Related
      ENSDARP00000053846.5, ENSDART00000053847.6
      Conserved Domains (2) summary
      cd01123
      Location:79 → 333
      Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
      pfam08423
      Location:65 → 332
      Rad51; Rad51

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      9474878..9566859
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017352460.3 → XP_017207949.2  DNA repair protein RAD51 homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M6Z2M3
      Conserved Domains (1) summary
      cd01123
      Location:79 → 309
      Rad51_DMC1_radA; B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a similiar ...

    2. XM_017352459.3 → XP_017207948.2  DNA repair protein RAD51 homolog 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M6YU53
      Conserved Domains (1) summary
      cd01123
      Location:72 → 326
      Rad51_DMC1_radA; B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a similiar ...
    Nucleotide Protein Strain
    Heading Accession and Version

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