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    irs2a insulin receptor substrate 2a [ Danio rerio (zebrafish) ]

    Gene ID: 393285, updated on 9-Dec-2024

    Summary

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    Official Symbol
    irs2aprovided by ZNC
    Official Full Name
    insulin receptor substrate 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-975
    See related
    Ensembl:ENSDARG00000037099 AllianceGenome:ZFIN:ZDB-GENE-040426-975
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:56306
    Summary
    Predicted to enable insulin receptor binding activity and phosphatidylinositol 3-kinase binding activity. Acts upstream of or within response to hypoxia. Predicted to be active in cytosol and plasma membrane. Is expressed in germ ring; head; and liver. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human IRS2 (insulin receptor substrate 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See irs2a in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (29211502..29229473)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (28407609..28424449)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene zgc:173948 Neighboring gene cysteinyl-tRNA synthetase 2, mitochondrial Neighboring gene ligase IV, DNA, ATP-dependent Neighboring gene NALCN channel auxiliary factor 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Serum lipoprotein-derived fatty acids regulate hypoxia-inducible factor. Shao W, et al. J Biol Chem, 2020 Dec 25. PMID 33109611, Free PMC Article
    2. Transcriptome analysis of severe hypoxic stress during development in zebrafish. Woods IG, et al. Genom Data, 2015 Dec. PMID 26697342, Free PMC Article
    3. Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity. Fukushima T, et al. Nat Commun, 2015 Apr 16. PMID 25879670
    4. Inversely Regulated Inflammation-Related Processes Mediate Anxiety-Obesity Links in Zebrafish Larvae and Adults. Yehuda H, et al. Cells, 2023 Jul 6. PMID 37443828, Free PMC Article
    5. Bergenin mitigates neuroinflammatory damage induced by high glucose: insights from Zebrafish, murine microbial cell line, and rat models. Yu W, et al. Front Pharmacol, 2024. PMID 39148536, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC56306

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables insulin receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    insulin receptor substrate 2a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200315.1 → NP_956609.1  insulin receptor substrate 2a

      See identical proteins and their annotated locations for NP_956609.1

      Status: PROVISIONAL

      Source sequence(s)
      BC050518
      UniProtKB/TrEMBL
      Q7ZU74
      Related
      ENSDARP00000053923.4, ENSDART00000053924.5
      Conserved Domains (3) summary
      cd01204
      Location:157 → 260
      PTB_IRS; Insulin receptor substrate phosphotyrosine-binding domain (PTBi)
      cd01257
      Location:24 → 126
      PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain
      pfam00169
      Location:25 → 123
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      29211502..29229473
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021466764.2 → XP_021322439.1  insulin receptor substrate 2a isoform X1

      UniProtKB/TrEMBL
      A0A8M9PD89
      Conserved Domains (2) summary
      cd01204
      Location:157 → 260
      PTB_IRS; Insulin receptor substrate phosphotyrosine-binding domain (PTBi)
      cd01257
      Location:24 → 126
      PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain

    RNA

    1. XR_002455723.2 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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