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    ddx20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 [ Danio rerio (zebrafish) ]

    Gene ID: 556273, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ddx20provided by ZNC
    Official Full Name
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 20provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-202
    See related
    Ensembl:ENSDARG00000061204 AllianceGenome:ZFIN:ZDB-GENE-030131-202
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    gemin3; fb59a11; wu:fb16g08; wu:fb59a11; si:dkey-193l3.3; si:dkey-193l3.4
    Summary
    Predicted to enable RNA helicase activity and mRNA binding activity. Acts upstream of or within fin regeneration; liver regeneration; and neuromast regeneration. Predicted to be part of SMN complex. Is expressed in brain. Orthologous to human DDX20 (DEAD-box helicase 20). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ddx20 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (28243226..28259817, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (28224087..28240627, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137490329 Neighboring gene potassium voltage-gated channel, Shal-related subfamily, member 3 Neighboring gene inka box actin regulator 2 Neighboring gene RAP1A, member of RAS oncogene family a Neighboring gene leiomodin 1a (smooth muscle)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A subset of SMN complex members have a specific role in tissue regeneration via ERBB pathway-mediated proliferation. Pei W, et al. NPJ Regen Med, 2020. PMID 32218991, Free PMC Article
    2. Processing of fish Ig heavy chain transcripts: diverse splicing patterns and unusual nonsense mediated decay. Quiniou SM, et al. Dev Comp Immunol, 2011 Sep. PMID 21168434
    3. Global repression of cancer gene expression in a zebrafish model of melanoma is linked to epigenetic regulation. Anelli V, et al. Zebrafish, 2009 Dec. PMID 20047469
    4. Forward Genetic Screens in Zebrafish Identify Pre-mRNA-Processing Pathways Regulating Early T Cell Development. Iwanami N, et al. Cell Rep, 2016 Nov 22. PMID 27880902, Free PMC Article
    5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fin regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within liver regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuromast regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spliceosomal snRNP assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within tissue regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SMN complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    probable ATP-dependent RNA helicase DDX20
    Names
    DEAD box protein 20
    NP_001116795.1
    XP_021333937.1
    XP_068079068.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001123323.1 → NP_001116795.1  probable ATP-dependent RNA helicase DDX20

      Status: PROVISIONAL

      Source sequence(s)
      BX664742
      UniProtKB/TrEMBL
      A0A286Y8P8, A0A8M1NG84, A0A8M3B4X2, F1R1C1
      Related
      ENSDARP00000081471.6, ENSDART00000087037.6
      Conserved Domains (3) summary
      COG0513
      Location:54 → 525
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      pfam00271
      Location:289 → 398
      Helicase_C; Helicase conserved C-terminal domain
      cl21455
      Location:56 → 260
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      28243226..28259817 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021478262.2 → XP_021333937.1  probable ATP-dependent RNA helicase DDX20 isoform X1

      UniProtKB/TrEMBL
      A0A286Y8P8, A0A8M3B4X2, A0A8M9PQW1
      Related
      ENSDARP00000143528.2, ENSDART00000175701.2
      Conserved Domains (1) summary
      COG0513
      Location:54 → 526
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

    2. XM_068222967.1 → XP_068079068.1  probable ATP-dependent RNA helicase DDX20 isoform X1

      UniProtKB/TrEMBL
      A0A286Y8P8, A0A8M3B4X2, A0A8M9PQW1
      Related
      ENSDARP00000118603.2, ENSDART00000134226.4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C218.1 GenPept UniProtKB/Swiss-Prot:P0C218

    Gene LinkOut

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