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    nlrx1 NLR family member X1 [ Danio rerio (zebrafish) ]

    Gene ID: 557335, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nlrx1provided by ZNC
    Official Full Name
    NLR family member X1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-071119-3
    See related
    Ensembl:ENSDARG00000073724 AllianceGenome:ZFIN:ZDB-GENE-071119-3
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to be involved in negative regulation of canonical NF-kappaB signal transduction. Predicted to be active in mitochondrion. Orthologous to human NLRX1 (NLR family member X1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See nlrx1 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (23468025..23485738, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (23532760..23550511, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene 5-phosphohydroxy-L-lysine phospho-lyase Neighboring gene NHERF family PDZ scaffold protein 4a Neighboring gene ATP-binding cassette, sub-family G (WHITE), member 4b Neighboring gene hydroxymethylbilane synthase, b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A zebrafish NLRX1 isoform downregulates fish IFN responses by targeting the adaptor STING. Zhao X, et al. J Virol, 2024 Feb 20. PMID 38193691, Free PMC Article
    2. The expanding and function of NLRC3 or NLRC3-like in teleost fish: Recent advances and novel insights. Chang MX, et al. Dev Comp Immunol, 2021 Jan. PMID 32896535
    3. A genomic view of the NOD-like receptor family in teleost fish: identification of a novel NLR subfamily in zebrafish. Laing KJ, et al. BMC Evol Biol, 2008 Feb 6. PMID 18254971, Free PMC Article
    4. Expression and protective role of two novel NACHT-containing proteins in pathogen infection. Hu YW, et al. Dev Comp Immunol, 2014 Oct. PMID 24858030
    5. Structure and evolutionary history of a large family of NLR proteins in the zebrafish. Howe K, et al. Open Biol, 2016 Apr. PMID 27248802, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A zebrafish NLRX1 isoform downregulates fish IFN responses by targeting the adaptor STING.
      Title: A zebrafish NLRX1 isoform downregulates fish IFN responses by targeting the adaptor STING.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in negative regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    NLR family member X1
    Names
    NLR-A5
    Nod5
    Nod9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      23468025..23485738 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021466415.2 → XP_021322090.1  NLR family member X1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PLL8
      Conserved Domains (3) summary
      sd00033
      Location:748 → 775
      LRR_RI; leucine-rich repeat [structural motif]
      cl21455
      Location:179 → 338
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
      cl26161
      Location:646 → 869
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    2. XM_680389.10 → XP_685481.4  NLR family member X1 isoform X1

      See identical proteins and their annotated locations for XP_685481.4

      UniProtKB/TrEMBL
      A0A8M9PCD5, E7FDW7
      Related
      ENSDARP00000126680.1, ENSDART00000152706.3
      Conserved Domains (4) summary
      sd00033
      Location:717 → 740
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:748 → 777
      LRR_AMN1; leucine-rich repeat [structural motif]
      cl21455
      Location:179 → 338
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
      cl26161
      Location:664 → 904
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    3. XM_021466414.2 → XP_021322089.1  NLR family member X1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PCD5, E7FDW7
      Related
      ENSDARP00000154296.1, ENSDART00000185523.1
      Conserved Domains (4) summary
      sd00033
      Location:717 → 740
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:748 → 777
      LRR_AMN1; leucine-rich repeat [structural motif]
      cl21455
      Location:179 → 338
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
      cl26161
      Location:664 → 904
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    Nucleotide Protein
    Heading Accession and Version

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