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    ppp1cb protein phosphatase 1, catalytic subunit, beta isozyme [ Danio rerio (zebrafish) ]

    Gene ID: 100003223, updated on 14-Nov-2024

    Summary

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    Official Symbol
    ppp1cbprovided by ZNC
    Official Full Name
    protein phosphatase 1, catalytic subunit, beta isozymeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030616-609
    See related
    Ensembl:ENSDARG00000044153 AllianceGenome:ZFIN:ZDB-GENE-030616-609
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fa09h01; wu:fa11e06; ik:tdsubc_2f2; si:zc214p16.4; xx:tdsubc_2f2
    Summary
    Enables protein heterodimerization activity. Acts upstream of or within convergent extension involved in axis elongation and liver development. Predicted to be active in cytoplasm and nucleus. Is expressed in intestine and liver. Human ortholog(s) of this gene implicated in Noonan syndrome-like disorder with loose anagen hair 2. Orthologous to human PPP1CB (protein phosphatase 1 catalytic subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See ppp1cb in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (25635950..25649075, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (25617562..25630686, complement)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene isoleucyl-tRNA synthetase 2, mitochondrial Neighboring gene RAB3 GTPase activating protein subunit 2 (non-catalytic) Neighboring gene phospholipase B1 Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 1a Neighboring gene uncharacterized LOC137488101

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Protein phosphatase 1 β paralogs encode the zebrafish myosin phosphatase catalytic subunit. Jayashankar V, et al. PLoS One, 2013. PMID 24040418, Free PMC Article
    2. Mypt1-mediated spatial positioning of Bmp2-producing cells is essential for liver organogenesis. Huang H, et al. Development, 2008 Oct. PMID 18776143, Free PMC Article
    3. Rho-regulated myosin phosphatase establishes the level of protrusive activity required for cell movements during zebrafish gastrulation. Weiser DC, et al. Development, 2009 Jul. PMID 19515695, Free PMC Article
    4. Insight into molecular pathways of retinal metabolism, associated with vitellogenesis in zebrafish. Levi L, et al. Am J Physiol Endocrinol Metab, 2012 Mar 15. PMID 22205629
    5. RNA-Seq reveals differential expression profiles and functional annotation of genes involved in retinal degeneration in Pde6c mutant Danio rerio. Saddala MS, et al. BMC Genomics, 2020 Feb 7. PMID 32033529, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. zebrafish have two genes encoding PP1beta, both of which can interact with Mypt1
      Title: Protein phosphatase 1 β paralogs encode the zebrafish myosin phosphatase catalytic subunit.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC136442

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within convergent extension involved in axis elongation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within convergent extension involved in axis elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within glycogen metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within liver development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase PP1-beta catalytic subunit
    Names
    plb
    ppp1cba
    NP_001004527.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004527.4 → NP_001004527.3  serine/threonine-protein phosphatase PP1-beta catalytic subunit

      Status: VALIDATED

      Source sequence(s)
      AL929207
      Related
      ENSDARP00000109442.3, ENSDART00000130955.3

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      25635950..25649075 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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