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    wee2 WEE2 oocyte meiosis inhibiting kinase [ Danio rerio (zebrafish) ]

    Gene ID: 327471, updated on 2-Nov-2024

    Summary

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    Official Symbol
    wee2provided by ZNC
    Official Full Name
    WEE2 oocyte meiosis inhibiting kinaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5682
    See related
    Ensembl:ENSDARG00000012718 AllianceGenome:ZFIN:ZDB-GENE-030131-5682
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:5913035; wu:fi13b10; zgc:123074; si:ch211-238n5.5
    Summary
    Predicted to enable protein tyrosine kinase activity. Predicted to be involved in regulation of meiosis I. Predicted to act upstream of or within meiotic cell cycle; mitotic cell cycle; and protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Orthologous to human WEE2 (WEE2 oocyte meiosis inhibiting kinase). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See wee2 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (20560706..20565982)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (20571640..20576916)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene acylglycerol kinase Neighboring gene DENN domain containing 11 Neighboring gene BH3 interacting domain death agonist Neighboring gene BCL2 like 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Light acts on the zebrafish circadian clock to suppress rhythmic mitosis and cell proliferation. Tamai TK, et al. J Biol Rhythms, 2012 Jun. PMID 22653891
    2. Comparative analysis of single-cell transcriptomics in human and Zebrafish oocytes. Can H, et al. BMC Genomics, 2020 Jul 8. PMID 32640983, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC123074, MGC162002

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of meiosis I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    wee1-like protein kinase 2
    Names
    WEE1 homolog 2
    wee1-like protein kinase 1B
    wee1B kinase
    NP_001032299.2
    NP_001038367.1
    XP_068070829.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037222.2 → NP_001032299.2  wee1-like protein kinase 2 isoform 1

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1.
      Source sequence(s)
      BX470166
      UniProtKB/Swiss-Prot
      Q1LX51
      Related
      ENSDARP00000121512.1, ENSDART00000136710.3
      Conserved Domains (3) summary
      cd14139
      Location:182 → 454
      PTKc_Wee1b; Catalytic domain of the Protein Tyrosine Kinase, Wee1b
      cl21499
      Location:428 → 511
      SPX; Domain found in Syg1, Pho81, XPR1, and related proteins
      pfam00069
      Location:189 → 455
      Pkinase; Protein kinase domain

    2. NM_001044902.1 → NP_001038367.1  wee1-like protein kinase 2 isoform 2

      See identical proteins and their annotated locations for NP_001038367.1

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (2) uses an alternate 5' most exon which results in a different 5' UTR and use of an alternate start codon compared to variant 1. The encoded isoform (2) is longer and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      BX470166
      UniProtKB/Swiss-Prot
      A4IFZ5, Q1LX50, Q1LX51, Q32PP5
      Related
      ENSDARP00000109848.2, ENSDART00000121699.4
      Conserved Domains (3) summary
      cd14139
      Location:187 → 459
      PTKc_Wee1b; Catalytic domain of the Protein Tyrosine Kinase, Wee1b
      cl21499
      Location:433 → 516
      SPX; Domain found in Syg1, Pho81, XPR1, and related proteins
      pfam00069
      Location:194 → 460
      Pkinase; Protein kinase domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      20560706..20565982
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068214728.1 → XP_068070829.1  wee1-like protein kinase 2 isoform X1

      Related
      ENSDARP00000040073.7, ENSDART00000040074.8

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395022.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      158766..164107
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q1LX51.2 GenPept UniProtKB/Swiss-Prot:Q1LX51

    Gene LinkOut

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