ctps1a CTP synthase 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ctps1aprovided by ZNC
Official Full Name: CTP synthase 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-808
See related: Ensembl:ENSDARG00000030700 AllianceGenome:ZFIN:ZDB-GENE-030131-808
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ctps; ctps1; ctpsa; cb1040; wu:fb49e03; wu:fe17b03
Summary: Predicted to enable CTP synthase activity and identical protein binding activity. Acts upstream of or within notochord development. Predicted to be active in cytoophidium and cytoplasm. Is expressed in several structures, including alar plate midbrain region; digestive system; immature eye; nervous system; and pectoral fin bud. Human ortholog(s) of this gene implicated in immunodeficiency 24. Orthologous to human CTPS1 (CTP synthase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 19

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (16016037..16027093)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (16111675..16122731)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CTPS forms the cytoophidium in zebrafish.
Title: CTPS forms the cytoophidium in zebrafish.
Data show that CTP synthase 1a (ctps1a) is more critical throughout the initial period of embryonic development than CTP synthase 1b (ctps1b).
Title: CTP synthase knockdown during early development distorts the nascent vertebral column and causes fluid retention in multiple tissues in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

fb73f09.x1 (e-PCR)
- UniSTS:187449

fb49e03.x1 (e-PCR)
- UniSTS:190616

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables CTP synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables CTP synthase activity	IEA Inferred from Electronic Annotation more info
enables CTP synthase activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 'de novo' CTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in CTP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within CTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in CTP biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within glutamine metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within notochord development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pyrimidine nucleobase biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within pyrimidine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoophidium	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: CTP synthase 1

Names: CTP synthase a; CTP synthetase 1; UTP--ammonia ligase 1

NP_954681.2

EC 6.3.4.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199211.2 → NP_954681.2 CTP synthase 1

Status: VALIDATED

Source sequence(s)

CR385068

UniProtKB/Swiss-Prot

Q6PEI7

UniProtKB/TrEMBL

A0A8M1PF99, A3QJW5

Related

ENSDARP00000121703.1, ENSDART00000131319.2

Conserved Domains (3) summary

cd01746
Location:303 → 548

GATase1_CTP_Synthase; Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase

PLN02327
Location:5 → 560

PLN02327; CTP synthase

pfam06418
Location:6 → 276

CTP_synth_N; CTP synthase N-terminus