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    mre11a MRE11 homolog A, double strand break repair nuclease [ Danio rerio (zebrafish) ]

    Gene ID: 406637, updated on 4-Jan-2025

    Summary

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    Official Symbol
    mre11aprovided by ZNC
    Official Full Name
    MRE11 homolog A, double strand break repair nucleaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2638
    See related
    Ensembl:ENSDARG00000105014 AllianceGenome:ZFIN:ZDB-GENE-040426-2638
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc38f05; zgc:64018; wu:fc38f05; wu:faa63d12
    Summary
    Predicted to enable single-stranded DNA endodeoxyribonuclease activity. Acts upstream of or within hematopoietic stem cell homeostasis and regulation of telomere maintenance. Predicted to be located in chromosome, telomeric region and nucleus. Predicted to be part of Mre11 complex. Predicted to be active in site of double-strand break. Is expressed in alar plate midbrain region; digestive system; eye; immature eye; and midbrain. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome; ataxia-telangiectasia-like disorder-1; endometrial cancer; gastrointestinal system cancer (multiple); and urinary bladder cancer. Orthologous to human MRE11 (MRE11 homolog, double strand break repair nuclease). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See mre11a in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (2857558..2887498)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (2894278..2924215)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene angiomotin like 1 Neighboring gene ankyrin repeat domain 49 Neighboring gene guanylate cyclase activator 1C Neighboring gene chromosome 15 C3orf52 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. UFMylation of MRE11 is essential for telomere length maintenance and hematopoietic stem cell survival. Lee L, et al. Sci Adv, 2021 Sep 24. PMID 34559557, Free PMC Article
    2. Tdp1 protects from topoisomerase 1-mediated chromosomal breaks in adult zebrafish but is dispensable during larval development. Zaksauskaite R, et al. Sci Adv, 2021 Jan. PMID 33514542, Free PMC Article
    3. Knock-In Strategy for Editing Human and Zebrafish Mitochondrial DNA Using Mito-CRISPR/Cas9 System. Bian WP, et al. ACS Synth Biol, 2019 Apr 19. PMID 30955321
    4. Cellular responses to ionizing radiation change quickly over time during early development in zebrafish. Honjo Y, et al. Cell Biol Int, 2019 May. PMID 30791195, Free PMC Article
    5. In vitro and in vivo studies of oxidative stress responses against acrylamide toxicity in zebrafish. Komoike Y, et al. J Hazard Mater, 2019 Mar 5. PMID 30453236

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 3'-5'-DNA exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA endodeoxyribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within double-strand break repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via nonhomologous end joining IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within hematopoietic stem cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic DNA double-strand break formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic G2 DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic intra-S DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Mre11 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Mre11 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in site of double-strand break IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    double-strand break repair protein MRE11
    Names
    MRE11 homolog, double strand break repair nuclease A
    meiotic recombination 11 homolog A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320259.1 → NP_001307188.1  double-strand break repair protein MRE11

      Status: VALIDATED

      Source sequence(s)
      CABZ01086035, CABZ01086036, CABZ01086037, CABZ01086038
      UniProtKB/TrEMBL
      A0A0R4ITV5, A0A8M9QPT3
      Related
      ENSDARP00000139437.1, ENSDART00000163434.3
      Conserved Domains (1) summary
      cl27188
      Location:11 → 403
      Mre11_DNA_bind; Mre11 DNA-binding presumed domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      2857558..2887498
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021481375.2 → XP_021337050.1  double-strand break repair protein MRE11 isoform X1

      UniProtKB/TrEMBL
      A0A0R4ITV5, A0A8M9QPT3
      Conserved Domains (1) summary
      cl27188
      Location:11 → 403
      Mre11_DNA_bind; Mre11 DNA-binding presumed domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001001407.1: Suppressed sequence

      Description
      NM_001001407.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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