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    dao.1 D-amino-acid oxidase, tandem duplicate 1 [ Danio rerio (zebrafish) ]

    Gene ID: 619259, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dao.1provided by ZNC
    Official Full Name
    D-amino-acid oxidase, tandem duplicate 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050913-127
    See related
    Ensembl:ENSDARG00000035602 AllianceGenome:ZFIN:ZDB-GENE-050913-127
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fb55b11; zgc:113922
    Summary
    Predicted to enable D-amino-acid oxidase activity. Predicted to be involved in D-alanine catabolic process; D-serine catabolic process; and proline catabolic process. Predicted to act upstream of or within D-amino acid metabolic process. Predicted to be located in several cellular components, including extracellular region; peroxisomal matrix; and presynaptic active zone. Predicted to be active in cytoplasm. Is expressed in yolk syncytial layer. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human DAO (D-amino acid oxidase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dao.1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (20187877..20195372, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (19684077..19691577, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 30 Neighboring gene SV2 related protein a Neighboring gene D-amino-acid oxidase, tandem duplicate 2 Neighboring gene D-amino-acid oxidase, tandem duplicate 3 Neighboring gene slingshot protein phosphatase 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Whole-genome expression profile in zebrafish embryos after chronic exposure to morphine: identification of new genes associated with neuronal function and mu opioid receptor expression. Herrero-Turrión MJ, et al. BMC Genomics, 2014 Oct 8. PMID 25294025, Free PMC Article
    2. Enoyl-CoA hydratase/3-hydroxyacyl CoA dehydrogenase is essential for the production of DHA in zebrafish. Yang G, et al. J Lipid Res, 2023 Mar. PMID 36592657, Free PMC Article
    3. Insights Into the Peroxisomal Protein Inventory of Zebrafish. Kamoshita M, et al. Front Physiol, 2022. PMID 35295584, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC113922

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables D-amino-acid oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables D-amino-acid oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-alanine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within D-amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in D-serine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proline catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisomal matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in presynaptic active zone IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    D-amino-acid oxidase, tandem duplicate 1
    Names
    D-amino-acid oxidase 1
    NP_001028912.1
    XP_005165240.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033740.1 → NP_001028912.1  D-amino-acid oxidase, tandem duplicate 1

      See identical proteins and their annotated locations for NP_001028912.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097016
      UniProtKB/TrEMBL
      Q4V981
      Conserved Domains (1) summary
      pfam01266
      Location:2 → 329
      DAO; FAD dependent oxidoreductase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      20187877..20195372 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005165183.4 → XP_005165240.1  D-amino-acid oxidase, tandem duplicate 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BCE8, A2BGT3, E7F7N4
      Related
      ENSDARP00000112531.1, ENSDART00000139675.2
      Conserved Domains (1) summary
      pfam01266
      Location:2 → 329
      DAO; FAD dependent oxidoreductase
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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