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    tbl3 transducin beta like 3 [ Danio rerio (zebrafish) ]

    Gene ID: 492761, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tbl3provided by ZNC
    Official Full Name
    transducin beta like 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041114-104
    See related
    Ensembl:ENSDARG00000052344 AllianceGenome:ZFIN:ZDB-GENE-041114-104
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:101778
    Summary
    Predicted to enable U3 snoRNA binding activity. Acts upstream of or within lymphocyte differentiation; regulation of cell cycle process; and thymus development. Predicted to be part of 90S preribosome. Predicted to be active in nucleolus. Is expressed in several structures, including brain; eye; fin bud; gut; and hematopoietic stem cell. Orthologous to human TBL3 (transducin beta like 3). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See tbl3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (62173159..62194652, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (61936529..61958022, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene GID complex subunit 4 homolog Neighboring gene NADPH oxidase organizer 1a Neighboring gene gastrula zinc finger protein XlCGF8.2DB-like Neighboring gene synthesis of cytochrome C oxidase 1 Neighboring gene zinc finger protein 1024

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish mutants with disrupted early T-cell and thymus development identified in early pressure screen. Trede NS, et al. Dev Dyn, 2008 Sep. PMID 18729230, Free PMC Article
    2. Zebrafish as a model for understanding the evolution of the vertebrate immune system and human primary immunodeficiency. Iwanami N. Exp Hematol, 2014 Aug. PMID 24824573
    3. Tbl3 regulates cell cycle length during zebrafish development. Hutchinson SA, et al. Dev Biol, 2012 Aug 15. PMID 22659140, Free PMC Article
    4. Transcriptome analysis reveals positive selection on the divergent between topmouth culter and zebrafish. Ren L, et al. Gene, 2014 Dec 1. PMID 25267534
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables U3 snoRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lymphocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cell cycle process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within thymus development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of 90S preribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transducin beta-like protein 3
    Names
    cey

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007402.1 → NP_001007403.1  transducin beta-like protein 3

      See identical proteins and their annotated locations for NP_001007403.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085436
      UniProtKB/TrEMBL
      Q5U3Q5
      Related
      ENSDARP00000068663.5, ENSDART00000074174.6
      Conserved Domains (4) summary
      COG2319
      Location:45 → 564
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:338 → 638
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08625
      Location:659 → 793
      Utp13; Utp13 specific WD40 associated domain
      sd00039
      Location:347 → 384
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      62173159..62194652 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394544.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      1..12951 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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