U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    apobb.1 apolipoprotein Bb, tandem duplicate 1 [ Danio rerio (zebrafish) ]

    Gene ID: 321166, updated on 14-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    apobb.1provided by ZNC
    Official Full Name
    apolipoprotein Bb, tandem duplicate 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9732
    See related
    Ensembl:ENSDARG00000022767 AllianceGenome:ZFIN:ZDB-GENE-030131-9732
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    apobb; apobl; cb235; zeh1207; sb:cb235; hm:zeh1207; wu:fb39c11; wu:fc51e12; si:ch211-219i10.1
    Summary
    Predicted to enable cholesterol transfer activity and low-density lipoprotein particle receptor binding activity. Acts upstream of or within cellular response to xenobiotic stimulus. Predicted to be part of low-density lipoprotein particle; mature chylomicron; and very-low-density lipoprotein particle. Is expressed in intestine; liver; and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); biliary tract cancer (multiple); familial hyperlipidemia (multiple); hypobetalipoproteinemia (multiple); and sickle cell anemia. Orthologous to human APOB (apolipoprotein B). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See apobb.1 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (31269724..31284893)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (31366845..31382013)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene protein disulfide isomerase family A, member 6 Neighboring gene hippocalcin-like 1 Neighboring gene solute carrier family 22 member 16 Neighboring gene uronyl 2-sulfotransferase a Neighboring gene uncharacterized LOC137488589

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The LipoGlo reporter system for sensitive and specific monitoring of atherogenic lipoproteins. Thierer JH, et al. Nat Commun, 2019 Jul 31. PMID 31366908, Free PMC Article
    2. Core fucosylation is required for midline patterning during zebrafish development. Seth A, et al. Dev Dyn, 2010 Dec. PMID 21069830, Free PMC Article
    3. Development of a convenient in vivo hepatotoxin assay using a transgenic zebrafish line with liver-specific DsRed expression. Zhang X, et al. PLoS One, 2014. PMID 24626481, Free PMC Article
    4. Zebrafish mutants provide insights into Apolipoprotein B functions during embryonic development and pathological conditions. Templehof H, et al. JCI Insight, 2021 Jul 8. PMID 34236046, Free PMC Article
    5. DHCR7 Expression Predicts Poor Outcomes and Mortality From Sepsis. Guirgis FW, et al. Crit Care Explor, 2023 Jun. PMID 37332366, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables lipid transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    apolipoprotein Bb, tandem duplicate 1
    Names
    apolipoprotein B, like

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030062.1 → NP_001025233.1  apolipoprotein Bb, tandem duplicate 1 precursor

      Status: PROVISIONAL

      Source sequence(s)
      BX511210
      UniProtKB/TrEMBL
      A0A8M1N7D8, Q5TZ29
      Related
      ENSDARP00000119179.1, ENSDART00000133353.2
      Conserved Domains (4) summary
      pfam01347
      Location:23 → 570
      Vitellogenin_N; Lipoprotein amino terminal region
      pfam06160
      Location:1912 → 2303
      EzrA; Septation ring formation regulator, EzrA
      pfam06448
      Location:925 → 1007
      DUF1081; Domain of Unknown Function (DUF1081)
      pfam09172
      Location:604 → 903
      DUF1943; Domain of unknown function (DUF1943)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      31269724..31284893
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005160629.4 → XP_005160686.1  apolipoprotein Bb, tandem duplicate 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B7H0
      Conserved Domains (4) summary
      pfam01347
      Location:32 → 579
      Vitellogenin_N; Lipoprotein amino terminal region
      pfam06160
      Location:1921 → 2312
      EzrA; Septation ring formation regulator, EzrA
      pfam06448
      Location:934 → 1016
      DUF1081; Domain of Unknown Function (DUF1081)
      pfam09172
      Location:613 → 912
      DUF1943; Domain of unknown function (DUF1943)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools