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    hspa4a heat shock protein 4a [ Danio rerio (zebrafish) ]

    Gene ID: 335865, updated on 2-Nov-2024

    Summary

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    Official Symbol
    hspa4aprovided by ZNC
    Official Full Name
    heat shock protein 4aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2832
    See related
    Ensembl:ENSDARG00000004754 AllianceGenome:ZFIN:ZDB-GENE-040426-2832
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    hspa4l; zgc:55506; wu:fc41d05; wu:fi59h02; wu:fj35c08
    Summary
    Predicted to enable adenyl-nucleotide exchange factor activity. Predicted to be involved in protein folding. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including gut; head; liver; pectoral fin bud; and somite. Human ortholog(s) of this gene implicated in Chagas disease. Orthologous to human HSPA4 (heat shock protein family A (Hsp70) member 4). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See hspa4a in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (43137497..43171249, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (43142321..43176073, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene prolyl 4-hydroxylase subunit alpha-2 Neighboring gene procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide 2 Neighboring gene zinc finger, CCHC domain containing 10 Neighboring gene AF4/FMR2 family, member 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish heat shock protein a4 genes in the intestinal epithelium are up-regulated during inflammation. Crawford KC, et al. Genesis, 2011 Dec. PMID 21557452
    2. Impaired Redox and Protein Homeostasis as Risk Factors and Therapeutic Targets in Toxin-Induced Biliary Atresia. Zhao X, et al. Gastroenterology, 2020 Sep. PMID 32505743, Free PMC Article
    3. Genome-Wide Identification of Hsp70 Genes in the Large Yellow Croaker (Larimichthys crocea) and Their Regulated Expression Under Cold and Heat Stress. Xu K, et al. Genes (Basel), 2018 Nov 29. PMID 30501106, Free PMC Article
    4. An integrated transcriptomic and proteomic approach characterizing estrogenic and metabolic effects of 17 alpha-ethinylestradiol in zebrafish (Danio rerio). De Wit M, et al. Gen Comp Endocrinol, 2010 Jun 1. PMID 20227414
    5. Zebrafish IRF1 regulates IFN antiviral response through binding to IFNϕ1 and IFNϕ3 promoters downstream of MyD88 signaling. Feng H, et al. J Immunol, 2015 Feb 1. PMID 25535281

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    heat shock 70 kDa protein 4a
    Names
    heat shock protein 4, like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214716.1 → NP_999881.1  heat shock 70 kDa protein 4a

      See identical proteins and their annotated locations for NP_999881.1

      Status: PROVISIONAL

      Source sequence(s)
      BC051152
      UniProtKB/TrEMBL
      B2GS41, F6NRR7, Q7ZU46
      Related
      ENSDARP00000026086.7, ENSDART00000021037.10
      Conserved Domains (2) summary
      pfam00012
      Location:3 → 692
      HSP70; Hsp70 protein
      cl17037
      Location:2 → 384
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      43137497..43171249 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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