actr2a actin related protein 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: actr2aprovided by ZNC
Official Full Name: actin related protein 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2894
See related: Ensembl:ENSDARG00000052438 AllianceGenome:ZFIN:ZDB-GENE-040426-2894
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: actr2; zgc:63719; hm:zeh1257
Summary: Predicted to enable ATP binding activity and actin binding activity. Predicted to contribute to actin filament binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation; positive regulation of double-strand break repair via homologous recombination; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm; nucleus; and site of double-strand break. Predicted to be part of Arp2/3 protein complex. Predicted to be active in cell cortex. Orthologous to human ACTR2 (actin related protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (51407520..51424999)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (50763721..50781200)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fi29b02.x1 (e-PCR)
- UniSTS:197195

AI353994 (e-PCR)
- UniSTS:206749

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
contributes_to actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Arp2/3 complex-mediated actin nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in Arp2/3 complex-mediated actin nucleation	IEA Inferred from Electronic Annotation more info
involved_in Arp2/3 complex-mediated actin nucleation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in regulation of double-strand break repair via nonhomologous end joining	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Arp2/3 protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Arp2/3 protein complex	IEA Inferred from Electronic Annotation more info
part_of Arp2/3 protein complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in site of double-strand break	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: actin-related protein 2-A

Names: ARP2 actin related protein 2a homolog; ARP2 actin-related protein 2 homolog; actin-like protein 2-A; actin-related protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213499.1 → NP_998664.1 actin-related protein 2-A

See identical proteins and their annotated locations for NP_998664.1

Status: PROVISIONAL

Source sequence(s)

BC055220

UniProtKB/Swiss-Prot

Q7SXW6

Related

ENSDARP00000068783.4, ENSDART00000074294.5

Conserved Domains (2) summary

smart00268
Location:6 → 388

ACTIN; Actin

cl17037
Location:10 → 382

NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily