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    LRRC9 leucine rich repeat containing 9 [ Homo sapiens (human) ]

    Gene ID: 341883, updated on 28-Oct-2024

    Summary

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    Official Symbol
    LRRC9provided by HGNC
    Official Full Name
    leucine rich repeat containing 9provided by HGNC
    Primary source
    HGNC:HGNC:19848
    See related
    Ensembl:ENSG00000131951 AllianceGenome:HGNC:19848
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Located in cytoplasm. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Restricted expression toward testis (RPKM 3.9) See more
    Orthologs
    mouse all
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    Genomic context

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    See LRRC9 in Genome Data Viewer
    Location:
    14q23.1
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (59919713..60066817)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (54125062..54272758)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (60386431..60533535)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene trans-L-3-hydroxyproline dehydratase Neighboring gene JNK1/MAPK8 associated membrane protein Neighboring gene coiled-coil domain containing 175 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:60124167-60124668 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:60124669-60125168 Neighboring gene reticulon 1 Neighboring gene microRNA 5586 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5807 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:60386022-60387221 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8463 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8462 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8464 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:60459076-60459307 Neighboring gene PCNX4 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8465 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8466 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:60558835-60559468 Neighboring gene Sharpr-MPRA regulatory region 1153 Neighboring gene pecanex 4 Neighboring gene dehydrogenase/reductase 7 Neighboring gene short coiled-coil protein pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A novel predicted ADP-ribosyltransferase-like family conserved in eukaryotic evolution. Wyżewski Z, et al. PeerJ, 2021. PMID 33854844, Free PMC Article
    2. Validating Missing Proteins in Human Sperm Cells by Targeted Mass-Spectrometry- and Antibody-based Methods. Carapito C, et al. J Proteome Res, 2017 Dec 1. PMID 28891297
    3. ZFP36L2 is a cell cycle-regulated CCCH protein necessary for DNA lesion-induced S-phase arrest. Noguchi A, et al. Biol Open, 2018 Mar 12. PMID 29449217, Free PMC Article
    4. Protein interaction landscapes revealed by advanced in vivo cross-linking-mass spectrometry. Wheat A, et al. Proc Natl Acad Sci U S A, 2021 Aug 10. PMID 34349018, Free PMC Article
    5. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. Capalbo L, et al. Nat Commun, 2019 Oct 4. PMID 31586073, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ46156

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 9

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355272.3 → NP_001342201.1  leucine-rich repeat-containing protein 9

      Status: VALIDATED

      Source sequence(s)
      AL133299, AL157911
      Consensus CDS
      CCDS86397.1
      UniProtKB/Swiss-Prot
      Q6ZRR7
      UniProtKB/TrEMBL
      A0A2R8Y4H4, H3BUS4
      Related
      ENSP00000493790.1, ENST00000647410.1
      Conserved Domains (4) summary
      sd00033
      Location:1141 → 1166
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:192 → 223
      LRR_AMN1; leucine-rich repeat [structural motif]
      NF033189
      Location:659 → 966
      internalin_A; class 1 internalin InlA
      cd21340
      Location:55 → 236
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    2. NM_001395648.1 → NP_001382577.1  leucine-rich repeat-containing protein 9

      Status: VALIDATED

      Source sequence(s)
      AL133299, AL157911
      Consensus CDS
      CCDS86397.1
      UniProtKB/Swiss-Prot
      Q6ZRR7
      UniProtKB/TrEMBL
      A0A2R8Y4H4, H3BUS4
      Related
      ENSP00000457773.2, ENST00000570145.2
      Conserved Domains (4) summary
      sd00033
      Location:1141 → 1166
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:192 → 223
      LRR_AMN1; leucine-rich repeat [structural motif]
      NF033189
      Location:659 → 966
      internalin_A; class 1 internalin InlA
      cd21340
      Location:55 → 236
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    RNA

    1. NR_075071.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL133299, AL157911

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      59919713..60066817
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024449566.2 → XP_024305334.1  leucine-rich repeat-containing protein 9 isoform X2

      UniProtKB/Swiss-Prot
      Q6ZRR7
      Conserved Domains (4) summary
      sd00033
      Location:698 → 717
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:192 → 223
      LRR_AMN1; leucine-rich repeat [structural motif]
      NF033188
      Location:1201 → 1371
      internalin_H; InlH/InlC2 family class 1 internalin
      NF033189
      Location:888 → 1271
      internalin_A; class 1 internalin InlA

    2. XM_024449567.2 → XP_024305335.1  leucine-rich repeat-containing protein 9 isoform X3

      UniProtKB/Swiss-Prot
      Q6ZRR7
      Conserved Domains (5) summary
      sd00033
      Location:1097 → 1122
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:192 → 223
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam13855
      Location:672 → 728
      LRR_8; Leucine rich repeat
      pfam14580
      Location:1192 → 1321
      LRR_9; Leucine-rich repeat
      cl03951
      Location:224 → 309
      CDC37_N; Cdc37 N terminal kinase binding

    3. XM_047431345.1 → XP_047287301.1  leucine-rich repeat-containing protein 9 isoform X6

    4. XM_024449569.1 → XP_024305337.1  leucine-rich repeat-containing protein 9 isoform X4

      UniProtKB/Swiss-Prot
      Q6ZRR7
      Related
      ENSP00000454748.1, ENST00000445360.5
      Conserved Domains (4) summary
      sd00033
      Location:1141 → 1166
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:192 → 223
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam13855
      Location:716 → 772
      LRR_8; Leucine rich repeat
      pfam14580
      Location:1236 → 1365
      LRR_9; Leucine-rich repeat

    5. XM_024449570.1 → XP_024305338.1  leucine-rich repeat-containing protein 9 isoform X5

      UniProtKB/Swiss-Prot
      Q6ZRR7
      Related
      ENSP00000454848.1, ENST00000254271.8
      Conserved Domains (4) summary
      sd00033
      Location:698 → 717
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:192 → 223
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam13855
      Location:1250 → 1306
      LRR_8; Leucine rich repeat
      pfam14580
      Location:97 → 246
      LRR_9; Leucine-rich repeat

    6. XM_024449574.2 → XP_024305342.1  leucine-rich repeat-containing protein 9 isoform X10

      Conserved Domains (5) summary
      sd00031
      Location:696 → 717
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:56 → 77
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:192 → 223
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam13855
      Location:716 → 772
      LRR_8; Leucine rich repeat
      pfam14580
      Location:97 → 246
      LRR_9; Leucine-rich repeat

    7. XM_024449571.2 → XP_024305339.1  leucine-rich repeat-containing protein 9 isoform X7

      Conserved Domains (5) summary
      sd00031
      Location:696 → 717
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:56 → 77
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:192 → 223
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam13855
      Location:716 → 772
      LRR_8; Leucine rich repeat
      pfam14580
      Location:97 → 246
      LRR_9; Leucine-rich repeat

    8. XM_024449572.2 → XP_024305340.1  leucine-rich repeat-containing protein 9 isoform X8

      Conserved Domains (5) summary
      sd00031
      Location:696 → 717
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:56 → 77
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:192 → 223
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam13855
      Location:716 → 772
      LRR_8; Leucine rich repeat
      pfam14580
      Location:97 → 246
      LRR_9; Leucine-rich repeat

    9. XM_024449573.2 → XP_024305341.1  leucine-rich repeat-containing protein 9 isoform X9

      Conserved Domains (5) summary
      sd00031
      Location:696 → 717
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:56 → 77
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:192 → 223
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam13855
      Location:716 → 772
      LRR_8; Leucine rich repeat
      pfam14580
      Location:97 → 246
      LRR_9; Leucine-rich repeat

    10. XM_024449575.2 → XP_024305343.1  leucine-rich repeat-containing protein 9 isoform X11

      Conserved Domains (5) summary
      sd00031
      Location:696 → 717
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:56 → 77
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:192 → 223
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam13855
      Location:716 → 772
      LRR_8; Leucine rich repeat
      pfam14580
      Location:97 → 246
      LRR_9; Leucine-rich repeat

    11. XM_024449563.2 → XP_024305331.1  leucine-rich repeat-containing protein 9 isoform X1

      UniProtKB/Swiss-Prot
      Q6ZRR7
      UniProtKB/TrEMBL
      A0A2R8Y4H4, H3BUS4
      Conserved Domains (4) summary
      sd00033
      Location:1141 → 1166
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:192 → 223
      LRR_AMN1; leucine-rich repeat [structural motif]
      NF033189
      Location:659 → 966
      internalin_A; class 1 internalin InlA
      cd21340
      Location:55 → 236
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    12. XM_024449568.2 → XP_024305336.1  leucine-rich repeat-containing protein 9 isoform X3

      UniProtKB/Swiss-Prot
      Q6ZRR7
      Conserved Domains (5) summary
      sd00033
      Location:1097 → 1122
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:192 → 223
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam13855
      Location:672 → 728
      LRR_8; Leucine rich repeat
      pfam14580
      Location:1192 → 1321
      LRR_9; Leucine-rich repeat
      cl03951
      Location:224 → 309
      CDC37_N; Cdc37 N terminal kinase binding

    13. XM_024449564.2 → XP_024305332.1  leucine-rich repeat-containing protein 9 isoform X1

      UniProtKB/Swiss-Prot
      Q6ZRR7
      UniProtKB/TrEMBL
      A0A2R8Y4H4, H3BUS4
      Conserved Domains (4) summary
      sd00033
      Location:1141 → 1166
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:192 → 223
      LRR_AMN1; leucine-rich repeat [structural motif]
      NF033189
      Location:659 → 966
      internalin_A; class 1 internalin InlA
      cd21340
      Location:55 → 236
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    14. XM_024449565.2 → XP_024305333.1  leucine-rich repeat-containing protein 9 isoform X1

      UniProtKB/Swiss-Prot
      Q6ZRR7
      UniProtKB/TrEMBL
      A0A2R8Y4H4, H3BUS4
      Conserved Domains (4) summary
      sd00033
      Location:1141 → 1166
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:192 → 223
      LRR_AMN1; leucine-rich repeat [structural motif]
      NF033189
      Location:659 → 966
      internalin_A; class 1 internalin InlA
      cd21340
      Location:55 → 236
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    RNA

    1. XR_002957549.2 RNA Sequence

    2. XR_002957550.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      54125062..54272758
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054375989.1 → XP_054231964.1  leucine-rich repeat-containing protein 9 isoform X2

    2. XM_054375990.1 → XP_054231965.1  leucine-rich repeat-containing protein 9 isoform X3

    3. XM_054375994.1 → XP_054231969.1  leucine-rich repeat-containing protein 9 isoform X6

    4. XM_054375992.1 → XP_054231967.1  leucine-rich repeat-containing protein 9 isoform X4

    5. XM_054375993.1 → XP_054231968.1  leucine-rich repeat-containing protein 9 isoform X12

    6. XM_054375998.1 → XP_054231973.1  leucine-rich repeat-containing protein 9 isoform X10

    7. XM_054375995.1 → XP_054231970.1  leucine-rich repeat-containing protein 9 isoform X7

    8. XM_054375996.1 → XP_054231971.1  leucine-rich repeat-containing protein 9 isoform X8

    9. XM_054375997.1 → XP_054231972.1  leucine-rich repeat-containing protein 9 isoform X9

    10. XM_054375999.1 → XP_054231974.1  leucine-rich repeat-containing protein 9 isoform X11

    11. XM_054375986.1 → XP_054231961.1  leucine-rich repeat-containing protein 9 isoform X1

      UniProtKB/TrEMBL
      A0A2R8Y4H4, H3BUS4

    12. XM_054375991.1 → XP_054231966.1  leucine-rich repeat-containing protein 9 isoform X3

    13. XM_054375987.1 → XP_054231962.1  leucine-rich repeat-containing protein 9 isoform X1

      UniProtKB/TrEMBL
      A0A2R8Y4H4, H3BUS4

    14. XM_054375988.1 → XP_054231963.1  leucine-rich repeat-containing protein 9 isoform X1

      UniProtKB/TrEMBL
      A0A2R8Y4H4, H3BUS4

    RNA

    1. XR_008488865.1 RNA Sequence

    2. XR_008488866.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_198499.1: Suppressed sequence

      Description
      NM_198499.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZRR7.2 GenPept UniProtKB/Swiss-Prot:Q6ZRR7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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