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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_032091.1Â RefSeqGene
- Range
-
5001..152570
- Download
- GenBank, FASTA, Sequence Viewer (Graphics), LRG_775
mRNA and Protein(s)
-
NM_001349370.3 → NP_001336299.1  histone-lysine N-methyltransferase SETD2 isoform 2
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
- Source sequence(s)
-
AC094020, AC127430
- Consensus CDS
-
CCDS93261.1
- UniProtKB/TrEMBL
- A0A1W2PPX9, A0A8I5KV15
- Related
- ENSP00000491413.2, ENST00000638947.2
- Conserved Domains (6) summary
-
- pfam05279
Location:1896 → 2079
- Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
- smart00570
Location:1451 → 1505
- AWS; associated with SET domains
- smart00317
Location:1506 → 1629
- SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
- smart00508
Location:1630 → 1646
- PostSET; Cysteine-rich motif following a subset of SET domains
- pfam00397
Location:2347 → 2376
- WW; WW domain
- pfam08236
Location:2425 → 2512
- SRI; SRI (Set2 Rpb1 interacting) domain
-
NM_014159.7 → NP_054878.5  histone-lysine N-methyltransferase SETD2 isoform 1
See identical proteins and their annotated locations for NP_054878.5
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) encodes the longer isoform (1).
- Source sequence(s)
-
AC094020, AC127430, AI671342, AK127782, AY576987, BC117162, BX649110, DA800082
- Consensus CDS
-
CCDS2749.2
- UniProtKB/Swiss-Prot
- O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9BYW2, Q9C0D1, Q9H696, Q9NZW9
- UniProtKB/TrEMBL
-
A0A8I5KV15
- Related
- ENSP00000386759.3, ENST00000409792.4
- Conserved Domains (6) summary
-
- pfam05279
Location:1940 → 2123
- Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
- smart00570
Location:1495 → 1549
- AWS; associated with SET domains
- smart00317
Location:1550 → 1673
- SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
- smart00508
Location:1674 → 1690
- PostSET; Cysteine-rich motif following a subset of SET domains
- pfam00397
Location:2391 → 2420
- WW; WW domain
- pfam08236
Location:2469 → 2548
- SRI; SRI (Set2 Rpb1 interacting) domain
RNA
-
NR_146158.3 RNA Sequence
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) contains an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
- Source sequence(s)
-
AC094020, AC127430
- Related
-
ENST00000431180.5
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000003.12Â Reference GRCh38.p14 Primary Assembly
- Range
-
47016436..47164840 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_024453487.2 → XP_024309255.1  histone-lysine N-methyltransferase SETD2 isoform X3
- UniProtKB/TrEMBL
-
A0A8I5KV15
- Related
- ENSP00000509568.1, ENST00000685005.1
- Conserved Domains (6) summary
-
- pfam05279
Location:1851 → 2034
- Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
- smart00570
Location:1451 → 1505
- AWS; associated with SET domains
- smart00317
Location:1506 → 1629
- SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
- smart00508
Location:1630 → 1646
- PostSET; Cysteine-rich motif following a subset of SET domains
- pfam00397
Location:2302 → 2331
- WW; WW domain
- pfam08236
Location:2380 → 2467
- SRI; SRI (Set2 Rpb1 interacting) domain
-
XM_047448045.1 → XP_047304001.1  histone-lysine N-methyltransferase SETD2 isoform X1
- UniProtKB/TrEMBL
-
A0A1W2PPX9
-
XM_024453488.2 → XP_024309256.1  histone-lysine N-methyltransferase SETD2 isoform X2
- UniProtKB/TrEMBL
-
A0A8I5KV15
- Conserved Domains (5) summary
-
- pfam05279
Location:1796 → 1979
- Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
- smart00570
Location:1451 → 1505
- AWS; associated with SET domains
- smart00508
Location:1530 → 1546
- PostSET; Cysteine-rich motif following a subset of SET domains
- pfam00397
Location:2247 → 2276
- WW; WW domain
- pfam08236
Location:2325 → 2412
- SRI; SRI (Set2 Rpb1 interacting) domain
-
XM_024453489.1 → XP_024309257.1  histone-lysine N-methyltransferase SETD2 isoform X4
- UniProtKB/TrEMBL
-
H7BXT4
- Conserved Domains (2) summary
-
- smart00570
Location:1451 → 1505
- AWS; associated with SET domains
- smart00317
Location:1506 → 1595
- SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
RNA
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XR_007095670.1 RNA Sequence
-
XR_002959514.2 RNA Sequence
-
XR_007095673.1 RNA Sequence
-
XR_007095672.1 RNA Sequence
-
XR_007095671.1 RNA Sequence
Alternate T2T-CHM13v2.0
Genomic
-
NC_060927.1Â Alternate T2T-CHM13v2.0
- Range
-
47032799..47180480 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
The following Reference Sequences have been suppressed. Explain
These RefSeqs were suppressed for the
cited reason(s). Suppressed RefSeqs do not appear in BLAST databases, related
sequence links, or BLAST links (BLink), but may still be retrieved by clicking on
their accession.version below.
-
NM_012271.1: Suppressed sequence
- Description
- NM_012271.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.