FFAR4 free fatty acid receptor 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FFAR4provided by HGNC
Official Full Name: free fatty acid receptor 4provided by HGNC
Primary source: HGNC:HGNC:19061
See related: Ensembl:ENSG00000186188 MIM:609044; AllianceGenome:HGNC:19061
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GT01; PGR4; OB10Q; BMIQ10; GPR120; GPR129; O3FAR1
Summary: This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing anti-inflammatory responses and insulin sensitizing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Expression: Biased expression in colon (RPKM 6.8), fat (RPKM 2.6) and 2 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q23.33

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (93566665..93590072)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (94446619..94470024)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (95326422..95349829)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FFAR4 activation inhibits lung adenocarcinoma via blocking respiratory chain complex assembly associated mitochondrial metabolism.
Title: FFAR4 activation inhibits lung adenocarcinoma via blocking respiratory chain complex assembly associated mitochondrial metabolism.
GPR120/FFAR4: A Potential New Therapeutic Target for Inflammatory Bowel Disease.
Title: GPR120/FFAR4: A Potential New Therapeutic Target for Inflammatory Bowel Disease.
Predictive value of first-trimester GPR120 levels in gestational diabetes mellitus.
Title: Predictive value of first-trimester GPR120 levels in gestational diabetes mellitus.
Free-Fatty Acid Receptor-4 (FFA4/GPR120) differentially regulates migration, invasion, proliferation and tumor growth of papillary renal cell carcinoma cells.
Title: Free-Fatty Acid Receptor-4 (FFA4/GPR120) differentially regulates migration, invasion, proliferation and tumor growth of papillary renal cell carcinoma cells.
Immune regulation of poly unsaturated fatty acids and free fatty acid receptor 4.
Title: Immune regulation of poly unsaturated fatty acids and free fatty acid receptor 4.
Oncogenic signaling of the free-fatty acid receptors FFA1 and FFA4 in human breast carcinoma cells.
Title: Oncogenic signaling of the free-fatty acid receptors FFA1 and FFA4 in human breast carcinoma cells.
GPR120 promotes metastasis but inhibits tumor growth in pancreatic ductal adenocarcinoma.
Title: GPR120 promotes metastasis but inhibits tumor growth in pancreatic ductal adenocarcinoma.
Reduced Free Fatty Acid Receptor 4 Gene Expression is Associated With Extreme Obesity and Insulin Resistance in Children.
Title: Reduced Free Fatty Acid Receptor 4 Gene Expression is Associated With Extreme Obesity and Insulin Resistance in Children.
Free fatty acid receptor 4 deletion attenuates colitis by modulating Treg Cells via ZBED6-IL33 pathway.
Title: Free fatty acid receptor 4 deletion attenuates colitis by modulating Treg Cells via ZBED6-IL33 pathway.
GPR120 prevents colorectal adenocarcinoma progression by sustaining the mucosal barrier integrity.
Title: GPR120 prevents colorectal adenocarcinoma progression by sustaining the mucosal barrier integrity.

Submit: New GeneRIF Correction See all GeneRIFs (77)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Body mass index quantitative trait locus 10 MedGen: C2675659 OMIM: 607514 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
Genome-wide association study of circulating retinol levels. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

D8S2279 (e-PCR)
- UniSTS:473907

D1S1423 (e-PCR)
- UniSTS:149619

D1S1425 (e-PCR)
- UniSTS:149621

GDB:335751 (e-PCR)
- UniSTS:156601

RH48297 (e-PCR)
- UniSTS:57803

NoName (e-PCR)
- UniSTS:483027

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables arrestin family protein binding	IDA Inferred from Direct Assay more info	PubMed
enables fatty acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acid binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables taste receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in brown fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of chemical stimulus involved in sensory perception of taste	IEA Inferred from Electronic Annotation more info
involved_in ghrelin secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in hormone secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cytokine production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of interleukin-1 beta production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of somatostatin secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of brown fat cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of glucagon secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of osteoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of D-glucose transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in white fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in ciliary membrane	IEA Inferred from Electronic Annotation more info
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in endocytic vesicle	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: free fatty acid receptor 4

Names: G-protein coupled receptor 120; G-protein coupled receptor 129; G-protein coupled receptor GT01; G-protein coupled receptor PGR4; Obesity, susceptibility to, on chromosome 10q; omega-3 fatty acid receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_032670.1 RefSeqGene

Range

5001..28408

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001195755.2 → NP_001182684.1 free fatty acid receptor 4 isoform GPR120-S

See identical proteins and their annotated locations for NP_001182684.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) is missing an in-frame coding exon compared to variant 1, resulting in a shorter isoform (GPR120-S) lacking a 16 aa protein segment compared to isoform GPR120-L.

Source sequence(s)

AI469384, AI732606, AK301525, AL356214, BC101175, BM757151, DA986310

Consensus CDS

CCDS55720.1

UniProtKB/Swiss-Prot

Q495H1, Q5NUL3, Q5VY25, Q5VY26, Q7Z605, Q86SM7

UniProtKB/TrEMBL

B4DWG6

Related

ENSP00000360536.5, ENST00000371481.9

Conserved Domains (1) summary

cd00637
Location:43 → 321

7tm_classA_rhodopsin-like; rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily
NM_181745.4 → NP_859529.2 free fatty acid receptor 4 isoform GPR120-L

See identical proteins and their annotated locations for NP_859529.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (GPR120-L).

Source sequence(s)

AI469384, AI732606, AK301525, AL356214, AY288417, BC101175, BM757151, DA986310

Consensus CDS

CCDS31248.1

UniProtKB/TrEMBL

B4DWG6

Related

ENSP00000360538.4, ENST00000371483.8

Conserved Domains (1) summary

pfam00001
Location:73 → 337

7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000010.11 Reference GRCh38.p14 Primary Assembly

Range

93566665..93590072

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011539746.4 → XP_011538048.1 free fatty acid receptor 4 isoform X1

UniProtKB/TrEMBL

S4R3L2

Conserved Domains (1) summary

pfam00001
Location:73 → 233

7tm_1; 7 transmembrane receptor (rhodopsin family)