Arap1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arap1provided by MGI
Official Full Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1provided by MGI
Primary source: MGI:MGI:1916960
See related: Ensembl:ENSMUSG00000032812 AllianceGenome:MGI:1916960
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Centd2; mKIAA0782; 2410002L19Rik
Summary: Predicted to enable several functions, including GTPase activator activity; R-SMAD binding activity; and phosphatidylinositol-3,4,5-trisphosphate binding activity. Predicted to be involved in several processes, including negative regulation of stress fiber assembly; positive regulation of filopodium assembly; and positive regulation of macromolecule metabolic process. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be active in plasma membrane and trans-Golgi network. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; genitourinary system; and hemolymphoid system gland. Orthologous to human ARAP1 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in spleen adult (RPKM 27.7), subcutaneous fat pad adult (RPKM 20.3) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E2; 7 54.56 cM

Exon count:: 43

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (100997296..101061793)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (101347921..101412586)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pro-fibrotic and apoptotic activities of circARAP1 in myocardial ischemia-reperfusion injury.
Title: Pro-fibrotic and apoptotic activities of circARAP1 in myocardial ischemia-reperfusion injury.
Arap1 loss causes retinal pigment epithelium phagocytic dysfunction and subsequent photoreceptor death.
Title: Arap1 loss causes retinal pigment epithelium phagocytic dysfunction and subsequent photoreceptor death.
competitive analytical gel-filtration chromatography and isothermal titration calorimetry (ITC) results showed that ARAP1 could compete with Cbl for CIN85 binding, which provides a biochemical basis for the regulatory roles of ARAP1 in the CIN85-mediated EGFR internalizing process.
Title: Biochemical and Structural Studies of the Interaction between ARAP1 and CIN85.
Quantitative trait loci genes analysis reveals association between T2D risk variants at the ARAP1/STARD10 locus and STARD10 but not ARAP1 expression.
Title: Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice.
Increased ARAP1 expression might contribute to type 2 diabetes susceptibility at this Genome-wide association studies locus.
Title: A common functional regulatory variant at a type 2 diabetes locus upregulates ARAP1 expression in the pancreatic beta cell.
Arap1 is highly expressed in the renal vasculature, and its expression is suppressed by angiotensin II.
Title: Angiotensin AT1 receptor-associated protein Arap1 in the kidney vasculature is suppressed by angiotensin II.
afadin regulates the cyclical activation and inactivation of Rap1, Rac1, and RhoA through SPA-1 and ARAP1.
Title: Regulation by afadin of cyclical activation and inactivation of Rap1, Rac1, and RhoA small G proteins at leading edges of moving NIH3T3 cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH66161 (e-PCR)
- UniSTS:47564

D0M7Mit138 (e-PCR)
- UniSTS:131037

D7Mit138 (e-PCR), detects polymorphism
- UniSTS:131037

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables GTPase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables R-SMAD binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISS Inferred from Sequence or Structural Similarity more info
enables type 1 angiotensin receptor binding	IEA Inferred from Electronic Annotation more info
enables type 1 angiotensin receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of stress fiber assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of GTPase activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of filopodium assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor recycling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of receptor recycling	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell projection organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell shape	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1

Names: centaurin, delta 2; cnt-d2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001040111.2 → NP_001035200.1 arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform 3

See identical proteins and their annotated locations for NP_001035200.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) is the longest transcript and it encodes isoform 3.

Source sequence(s)

AC129079

Consensus CDS

CCDS40041.1

UniProtKB/Swiss-Prot

Q4LDD4

Related

ENSMUSP00000102624.3, ENSMUST00000107010.9

Conserved Domains (11) summary

cd09490
Location:6 → 68

SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)

smart00454
Location:10 → 65

SAM; Sterile alpha motif

cd04385
Location:959 → 1137

RhoGAP_ARAP; RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ...

cd13253
Location:331 → 422

PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1

cd13254
Location:438 → 527

PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2

cd13256
Location:745 → 851

PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3

cd13259
Location:1265 → 1393

PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5

pfam00169
Location:330 → 420

PH; PH domain

pfam01412
Location:537 → 653

ArfGap; Putative GTPase activating protein for Arf

cl00155
Location:1174 → 1262

UBQ; Ubiquitin-like proteins

cl17171
Location:864 → 954

PH-like; Pleckstrin homology-like domain
NM_001040112.2 → NP_001035201.1 arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform 1

See identical proteins and their annotated locations for NP_001035201.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and lacks some 5' coding sequence, compared to variant 3. These differences cause translation initiation at a downstream AUG and an isoform (1) with a shorter N-terminus compared to isoform 3. Variants 1 and 4 encode the same protein.

Source sequence(s)

AC129079

Consensus CDS

CCDS21510.1

UniProtKB/Swiss-Prot

Q4LDD4

Related

ENSMUSP00000081957.6, ENSMUST00000084895.12

Conserved Domains (8) summary

cd04385
Location:711 → 889

RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...

cd13253
Location:83 → 174

PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1

cd13254
Location:190 → 279

PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2

cd13256
Location:497 → 603

PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3

cd13259
Location:1017 → 1145

PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5

cd17226
Location:925 → 1017

RA_ARAP1; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1)

cd08837
Location:289 → 404

ArfGap_ARAP; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing proteins

cl17171
Location:616 → 706

PH-like; Pleckstrin homology-like domain
NM_001407801.1 → NP_001394730.1 arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform 4

Status: VALIDATED

Source sequence(s)

AC129079
NM_001407803.1 → NP_001394732.1 arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform 5

Status: VALIDATED

Source sequence(s)

AC129079

UniProtKB/Swiss-Prot

B2RUJ3, Q3UDD2, Q3US99, Q4LDD4, Q58ET6, Q6PEQ9, Q6ZQ48

Conserved Domains (9) summary

cd09490
Location:6 → 68

SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)

cd04385
Location:959 → 1137

RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...

cd13253
Location:331 → 422

PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1

cd13254
Location:438 → 527

PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2

cd13256
Location:745 → 851

PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3

cd13259
Location:1265 → 1404

PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5

cd17226
Location:1173 → 1265

RA_ARAP1; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1)

cd08837
Location:537 → 652

ArfGap_ARAP; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing proteins

cl17171
Location:864 → 954

PH-like; Pleckstrin homology-like domain
NM_027180.4 → NP_081456.2 arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform 1

See identical proteins and their annotated locations for NP_081456.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR and lacks some 5' coding sequence, compared to variant 3. These differences cause translation initiation at a downstream AUG and an isoform (1) with a shorter N-terminus compared to isoform 3. Variants 1 and 4 encode the same protein.

Source sequence(s)

AC129079

Consensus CDS

CCDS21510.1

UniProtKB/Swiss-Prot

Q4LDD4

Conserved Domains (8) summary

cd04385
Location:711 → 889

RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...

cd13253
Location:83 → 174

PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1

cd13254
Location:190 → 279

PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2

cd13256
Location:497 → 603

PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3

cd13259
Location:1017 → 1145

PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5

cd17226
Location:925 → 1017

RA_ARAP1; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1)

cd08837
Location:289 → 404

ArfGap_ARAP; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing proteins

cl17171
Location:616 → 706

PH-like; Pleckstrin homology-like domain
NM_198096.2 → NP_932764.1 arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and lacks some 5' coding sequence, compared to variant 3. These differences cause translation initiation at a downstream AUG and an isoform (2) with a shorter N-terminus compared to isoform 3.

Source sequence(s)

AC129079

Consensus CDS

CCDS40042.1

UniProtKB/TrEMBL

E9PUB0

Related

ENSMUSP00000095844.3, ENSMUST00000098243.4

Conserved Domains (6) summary

cd04385
Location:245 → 423

RhoGAP_ARAP; RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ...

cd13256
Location:31 → 137

PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3

cd13259
Location:551 → 679

PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5

pfam00169
Location:32 → 136

PH; PH domain

cl00155
Location:460 → 548

UBQ; Ubiquitin-like proteins

cl17171
Location:150 → 240

PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

100997296..101061793

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030242973.2 → XP_030098833.1 arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X2

Conserved Domains (8) summary

cd04385
Location:716 → 894

RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...

cd13253
Location:88 → 179

PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1

cd13254
Location:195 → 284

PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2

cd13256
Location:502 → 608

PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3

cd13259
Location:1022 → 1161

PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5

cd17226
Location:930 → 1022

RA_ARAP1; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1)

cd08837
Location:294 → 409

ArfGap_ARAP; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing proteins

cl17171
Location:621 → 711

PH-like; Pleckstrin homology-like domain
XM_030242974.2 → XP_030098834.1 arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X5

Conserved Domains (8) summary

cd04385
Location:643 → 821

RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...

cd13253
Location:15 → 106

PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1

cd13254
Location:122 → 211

PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2

cd13256
Location:429 → 535

PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3

cd13259
Location:949 → 1088

PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5

cd17226
Location:857 → 949

RA_ARAP1; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1)

cd08837
Location:221 → 336

ArfGap_ARAP; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing proteins

cl17171
Location:548 → 638

PH-like; Pleckstrin homology-like domain
XM_006508188.5 → XP_006508251.1 arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1

See identical proteins and their annotated locations for XP_006508251.1

UniProtKB/Swiss-Prot

B2RUJ3, Q3UDD2, Q3US99, Q4LDD4, Q58ET6, Q6PEQ9, Q6ZQ48

Related

ENSMUSP00000081958.4, ENSMUST00000084896.10

Conserved Domains (9) summary

cd09490
Location:6 → 68

SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)

cd04385
Location:959 → 1137

RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...

cd13253
Location:331 → 422

PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1

cd13254
Location:438 → 527

PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2

cd13256
Location:745 → 851

PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3

cd13259
Location:1265 → 1404

PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5

cd17226
Location:1173 → 1265

RA_ARAP1; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1)

cd08837
Location:537 → 652

ArfGap_ARAP; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing proteins

cl17171
Location:864 → 954

PH-like; Pleckstrin homology-like domain
XM_006508187.3 → XP_006508250.1 arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1

See identical proteins and their annotated locations for XP_006508250.1

UniProtKB/Swiss-Prot

B2RUJ3, Q3UDD2, Q3US99, Q4LDD4, Q58ET6, Q6PEQ9, Q6ZQ48

Conserved Domains (9) summary

cd09490
Location:6 → 68

SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)

cd04385
Location:959 → 1137

RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...

cd13253
Location:331 → 422

PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1

cd13254
Location:438 → 527

PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2

cd13256
Location:745 → 851

PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3

cd13259
Location:1265 → 1404

PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5

cd17226
Location:1173 → 1265

RA_ARAP1; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1)

cd08837
Location:537 → 652

ArfGap_ARAP; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing proteins

cl17171
Location:864 → 954

PH-like; Pleckstrin homology-like domain
XM_011241897.4 → XP_011240199.1 arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1

See identical proteins and their annotated locations for XP_011240199.1

UniProtKB/Swiss-Prot

B2RUJ3, Q3UDD2, Q3US99, Q4LDD4, Q58ET6, Q6PEQ9, Q6ZQ48

Conserved Domains (9) summary

cd09490
Location:6 → 68

SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)

cd04385
Location:959 → 1137

RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...

cd13253
Location:331 → 422

PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1

cd13254
Location:438 → 527

PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2

cd13256
Location:745 → 851

PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3

cd13259
Location:1265 → 1404

PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5

cd17226
Location:1173 → 1265

RA_ARAP1; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1)

cd08837
Location:537 → 652

ArfGap_ARAP; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing proteins

cl17171
Location:864 → 954

PH-like; Pleckstrin homology-like domain
XM_036153422.1 → XP_036009315.1 arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X4

Conserved Domains (8) summary

cd04385
Location:711 → 889

RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...

cd13253
Location:83 → 174

PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1

cd13254
Location:190 → 279

PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2

cd13256
Location:497 → 603

PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3

cd13259
Location:1017 → 1145

PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5

cd17226
Location:925 → 1017

RA_ARAP1; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1)

cd08837
Location:289 → 404

ArfGap_ARAP; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing proteins

cl17171
Location:616 → 706

PH-like; Pleckstrin homology-like domain
XM_006508190.3 → XP_006508253.1 arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X3

See identical proteins and their annotated locations for XP_006508253.1

Conserved Domains (8) summary

cd04385
Location:711 → 889

RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...

cd13253
Location:83 → 174

PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1

cd13254
Location:190 → 279

PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2

cd13256
Location:497 → 603

PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3

cd13259
Location:1017 → 1156

PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5

cd17226
Location:925 → 1017

RA_ARAP1; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1)

cd08837
Location:289 → 404

ArfGap_ARAP; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing proteins

cl17171
Location:616 → 706

PH-like; Pleckstrin homology-like domain
XM_006508193.3 → XP_006508256.1 arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X5

Conserved Domains (8) summary

cd04385
Location:643 → 821

RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...

cd13253
Location:15 → 106

PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1

cd13254
Location:122 → 211

PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2

cd13256
Location:429 → 535

PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3

cd13259
Location:949 → 1088

PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5

cd17226
Location:857 → 949

RA_ARAP1; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1)

cd08837
Location:221 → 336

ArfGap_ARAP; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing proteins

cl17171
Location:548 → 638

PH-like; Pleckstrin homology-like domain
XM_006508192.3 → XP_006508255.1 arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X3

See identical proteins and their annotated locations for XP_006508255.1

Conserved Domains (8) summary

cd04385
Location:711 → 889

RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...

cd13253
Location:83 → 174

PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1

cd13254
Location:190 → 279

PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2

cd13256
Location:497 → 603

PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3

cd13259
Location:1017 → 1156

PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5

cd17226
Location:925 → 1017

RA_ARAP1; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1)

cd08837
Location:289 → 404

ArfGap_ARAP; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing proteins

cl17171
Location:616 → 706

PH-like; Pleckstrin homology-like domain
XM_006508191.5 → XP_006508254.1 arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X3

See identical proteins and their annotated locations for XP_006508254.1

Conserved Domains (8) summary

cd04385
Location:711 → 889

RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...

cd13253
Location:83 → 174

PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1

cd13254
Location:190 → 279

PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2

cd13256
Location:497 → 603

PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3

cd13259
Location:1017 → 1156

PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5

cd17226
Location:925 → 1017

RA_ARAP1; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1)

cd08837
Location:289 → 404

ArfGap_ARAP; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing proteins

cl17171
Location:616 → 706

PH-like; Pleckstrin homology-like domain
XM_036153421.1 → XP_036009314.1 arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X3

Conserved Domains (8) summary

cd04385
Location:711 → 889

RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...

cd13253
Location:83 → 174

PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1

cd13254
Location:190 → 279

PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2

cd13256
Location:497 → 603

PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3

cd13259
Location:1017 → 1156

PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5

cd17226
Location:925 → 1017

RA_ARAP1; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1)

cd08837
Location:289 → 404

ArfGap_ARAP; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing proteins

cl17171
Location:616 → 706

PH-like; Pleckstrin homology-like domain