NR1I3 nuclear receptor subfamily 1 group I member 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NR1I3provided by HGNC
Official Full Name: nuclear receptor subfamily 1 group I member 3provided by HGNC
Primary source: HGNC:HGNC:7969
See related: Ensembl:ENSG00000143257 MIM:603881; AllianceGenome:HGNC:7969
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CAR; CAR1; MB67
Summary: This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. In addition to drug metabolism, the CAR protein is also reported to regulate genes involved in glucose metabolism, lipid metabolism, cell proliferation, and circadian clock regulation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2020]
Expression: Biased expression in liver (RPKM 24.0), kidney (RPKM 3.5) and 6 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 1q23.3

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (161229669..161238203, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (160367115..160375669, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (161199459..161207993, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interaction with YAP underlies the species differences between humans and rodents in CAR-dependent hepatocyte proliferation.
Title: Interaction with YAP underlies the species differences between humans and rodents in CAR-dependent hepatocyte proliferation.
Distinct Roles of the Sister Nuclear Receptors PXR and CAR in Liver Cancer Development.
Title: Distinct Roles of the Sister Nuclear Receptors PXR and CAR in Liver Cancer Development.
Human constitutive androstane receptor represses liver cancer development and hepatoma cell proliferation by inhibiting erythropoietin signaling.
Title: Human constitutive androstane receptor represses liver cancer development and hepatoma cell proliferation by inhibiting erythropoietin signaling.
Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation.
Title: Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation.
Polymorphisms at CYP enzymes, NR1I2 and NR1I3 in association with virologic response to antiretroviral therapy in Brazilian HIV-positive individuals.
Title: Polymorphisms at CYP enzymes, NR1I2 and NR1I3 in association with virologic response to antiretroviral therapy in Brazilian HIV-positive individuals.
Xenobiotic Receptor CAR Is Highly Induced in Psoriasis and Promotes Keratinocyte Proliferation.
Title: Xenobiotic Receptor CAR Is Highly Induced in Psoriasis and Promotes Keratinocyte Proliferation.
Activation of the Constitutive Androstane Receptor Inhibits Leukocyte Adhesiveness to Dysfunctional Endothelium.
Title: Activation of the Constitutive Androstane Receptor Inhibits Leukocyte Adhesiveness to Dysfunctional Endothelium.
Role of the constitutive androstane receptor (CAR) in human liver cancer.
Title: Role of the constitutive androstane receptor (CAR) in human liver cancer.
Regulation of CAR and PXR Expression in Health and Disease.
Title: Regulation of CAR and PXR Expression in Health and Disease.
Long non-coding RNA F11-AS1 inhibits HBV-related hepatocellular carcinoma progression by regulating NR1I3 via binding to microRNA-211-5p.
Title: Long non-coding RNA F11-AS1 inhibits HBV-related hepatocellular carcinoma progression by regulating NR1I3 via binding to microRNA-211-5p.

Submit: New GeneRIF Correction See all GeneRIFs (103)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

D11S2921 (e-PCR)
- UniSTS:152074

NoName (e-PCR)
- UniSTS:490253

NoName (e-PCR)
- UniSTS:480797

PMC156606P1 (e-PCR)
- UniSTS:271408

D8S2278 (e-PCR)
- UniSTS:473906

sY3084 (e-PCR)
- UniSTS:515126

RH71314 (e-PCR)
- UniSTS:63287

D1S3429 (e-PCR)
- UniSTS:83529

RH70980 (e-PCR)
- UniSTS:59729

RH103810 (e-PCR)
- UniSTS:98135

L18426 (e-PCR)
- UniSTS:34648

G33032 (e-PCR)
- UniSTS:117609

PMC162252P1 (e-PCR)
- UniSTS:271468

PMC162252P2 (e-PCR)
- UniSTS:271469

NoName (e-PCR)
- UniSTS:482417

A009Z46 (e-PCR)
- UniSTS:9977

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	TAS Traceable Author Statement more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in osteoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
located_in chromatin	ISA Inferred from Sequence Alignment more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Go to the top of the page Help

Preferred Names: nuclear receptor subfamily 1 group I member 3

Names: constitutive activator of retinoid response; constitutive active receptor; constitutive active response; constitutive androstane receptor; orphan nuclear hormone receptor; orphan nuclear receptor MB67

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029113.1 RefSeqGene

Range

5008..13542

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001077469.3 → NP_001070937.1 nuclear receptor subfamily 1 group I member 3 isoform 6

Status: REVIEWED

Description

Transcript Variant: This variant (6), also known as SV-1, uses two alternate splice sites in the 3' coding region, compared to variant 1. The resulting protein (isoform 6) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AA918394, AY572806, CB124867

Consensus CDS

CCDS44261.1

UniProtKB/TrEMBL

E9PCF2

Related

ENSP00000412672.2, ENST00000428574.6

Conserved Domains (2) summary

cd07156
Location:11 → 82

NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers

cl11397
Location:106 → 311

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_001077470.3 → NP_001070938.1 nuclear receptor subfamily 1 group I member 3 isoform 11

See identical proteins and their annotated locations for NP_001070938.1

Status: REVIEWED

Description

Transcript Variant: This variant (11), also known as SV-3, lacks two alternate in-frame exons and uses an alternate splice site, compared to variant 1. The resulting protein (isoform 11) is shorter, uses an upstream start codon, and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AA918394, AY572808, CB124867

Consensus CDS

CCDS53407.1

UniProtKB/TrEMBL

B6ZGT2

Related

ENSP00000424345.1, ENST00000504010.5

Conserved Domains (2) summary

cl02596
Location:7 → 53

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

cl11397
Location:77 → 278

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_001077471.3 → NP_001070939.1 nuclear receptor subfamily 1 group I member 3 isoform 5

See identical proteins and their annotated locations for NP_001070939.1

Status: REVIEWED

Description

Transcript Variant: This variant (5), also known as SV-5 or CAR3, lacks an alternate in-frame exon and uses an alternate splice site, compared to variant 1. The resulting protein (isoform 5) is shorter than isoform 1.

Source sequence(s)

AA918394, AY572810, CB124867

Consensus CDS

CCDS44262.1

UniProtKB/TrEMBL

B6ZGT2

Related

ENSP00000356963.4, ENST00000367984.8

Conserved Domains (2) summary

cd07156
Location:11 → 82

NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers

cl11397
Location:106 → 307

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_001077472.3 → NP_001070940.1 nuclear receptor subfamily 1 group I member 3 isoform 9

See identical proteins and their annotated locations for NP_001070940.1

Status: REVIEWED

Description

Transcript Variant: This variant (9), also known as SV-6, lacks an alternate in-frame exon in the 5' coding region and uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting protein (isoform 9) is shorter, uses an upstream start codon, and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AA918394, AY572811, CB124867

Consensus CDS

CCDS41427.1

UniProtKB/TrEMBL

D6REZ7

Related

ENSP00000356960.3, ENST00000367981.7

Conserved Domains (2) summary

cd06934
Location:77 → 322

NR_LBD_PXR_like; The ligand binding domain of xenobiotic receptors:pregnane X receptor and constitutive androstane receptor

cl02596
Location:7 → 53

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
NM_001077473.3 → NP_001070941.1 nuclear receptor subfamily 1 group I member 3 isoform 12

Status: REVIEWED

Description

Transcript Variant: This variant (12), also known as SV-7, lacks an alternate in-frame exon in the 5' coding region and uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting protein (isoform 12) is shorter, uses an upstream start codon, and has distinct N- and C-termini, compared to isoform 1.

Source sequence(s)

AA918394, AY572812, CB124867

Consensus CDS

CCDS53411.1

UniProtKB/TrEMBL

E9PCF2

Related

ENSP00000399361.2, ENST00000412844.6

Conserved Domains (2) summary

cl02596
Location:7 → 53

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

cl11397
Location:77 → 286

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_001077474.3 → NP_001070942.1 nuclear receptor subfamily 1 group I member 3 isoform 8

Status: REVIEWED

Description

Transcript Variant: This variant (8), also known as SV-8, lacks an alternate in-frame exon and uses two alternate splice sites in the 3' coding region, compared to variant 1. The resulting protein (isoform 8) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AA918394, AY572813, CB124867

Consensus CDS

CCDS53405.1

UniProtKB/TrEMBL

B6ZGT2

Related

ENSP00000424934.1, ENST00000505005.5

Conserved Domains (2) summary

cd07156
Location:11 → 82

NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers

cl11397
Location:106 → 267

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_001077475.3 → NP_001070943.1 nuclear receptor subfamily 1 group I member 3 isoform 15

Status: REVIEWED

Description

Transcript Variant: This variant (15), also known as SV-11, lacks two alternate in-frame exons and uses two alternate splice sites, compared to variant 1. The resulting protein (isoform 15) is shorter, uses an upstream start codon, and has distinct N- and C-termini, compared to isoform 1.

Source sequence(s)

AA918394, AY572816, CB124867

Consensus CDS

CCDS53406.1

UniProtKB/TrEMBL

E9PCF2

Related

ENSP00000425417.1, ENST00000512372.5

Conserved Domains (2) summary

cl02596
Location:7 → 53

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

cl11397
Location:77 → 238

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_001077476.3 → NP_001070944.1 nuclear receptor subfamily 1 group I member 3 isoform 13

Status: REVIEWED

Description

Transcript Variant: This variant (13), also known as SV-12, lacks an alternate in-frame exon in the 5' coding region and uses two alternate splice sites in the 3' coding region, compared to variant 1. The resulting protein (isoform 13) is shorter, uses an upstream start codon, and has distinct N- and C-termini, compared to isoform 1.

Source sequence(s)

AA918394, AY572817, CB124867

Consensus CDS

CCDS53410.1

UniProtKB/TrEMBL

E9PCF2

Related

ENSP00000423666.1, ENST00000508740.5

Conserved Domains (2) summary

cl02596
Location:7 → 53

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

cl11397
Location:77 → 282

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_001077477.3 → NP_001070945.1 nuclear receptor subfamily 1 group I member 3 isoform 14

Status: REVIEWED

Description

Transcript Variant: This variant (14), also known as SV-13, lacks an alternate in-frame exon in the 5' coding region and uses three alternate splice sites in the 3' coding region, compared to variant 1. The resulting protein (isoform 14) is shorter, uses an upstream start codon, and has distinct N- and C-termini, compared to isoform 1.

Source sequence(s)

AA918394, AY572818, CB124867

Consensus CDS

CCDS53408.1

UniProtKB/TrEMBL

E9PCF2

Related

ENSP00000407446.2, ENST00000437437.6

Conserved Domains (2) summary

cl02596
Location:7 → 53

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

cl11397
Location:77 → 277

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_001077478.3 → NP_001070946.1 nuclear receptor subfamily 1 group I member 3 isoform 7

Status: REVIEWED

Description

Transcript Variant: This variant (7), also known as SV-14, uses two alternate splice sites in the 3' coding region, compared to variant 1. The resulting protein (isoform 7) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AA918394, AY572819, CB124867

Consensus CDS

CCDS44260.1

UniProtKB/TrEMBL

E9PCF2

Related

ENSP00000406493.2, ENST00000442691.6

Conserved Domains (2) summary

cd07156
Location:11 → 82

NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers

cl11397
Location:106 → 310

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_001077479.3 → NP_001070947.1 nuclear receptor subfamily 1 group I member 3 isoform 10

See identical proteins and their annotated locations for NP_001070947.1

Status: REVIEWED

Description

Transcript Variant: This variant (10), also known as SV-22, lacks an alternate in-frame exon in the 5' coding region and uses two alternate splice sites in the 3' coding region, compared to variant 1. The resulting protein (isoform 10) is shorter, uses an upstream start codon, and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AA918394, AY572827, CB124867

Consensus CDS

CCDS53409.1

UniProtKB/TrEMBL

D6REZ7

Related

ENSP00000427175.1, ENST00000511676.5

Conserved Domains (2) summary

cd06934
Location:77 → 317

NR_LBD_PXR_like; The ligand binding domain of xenobiotic receptors:pregnane X receptor and constitutive androstane receptor

cl02596
Location:7 → 53

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
NM_001077480.3 → NP_001070948.1 nuclear receptor subfamily 1 group I member 3 isoform 2

See identical proteins and their annotated locations for NP_001070948.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.

Source sequence(s)

AA918394, AL590714, BC069626, CB124867

Consensus CDS

CCDS41430.1

UniProtKB/Swiss-Prot

E9PB75, E9PC13, E9PDU3, E9PGH6, E9PH10, E9PHC8, E9PHN4, F1D8Q0, F1D8Q1, Q0VAC9, Q14994, Q4U0F0, Q5VTW5, Q5VTW6, Q6GZ68, Q6GZ76, Q6GZ77, Q6GZ78, Q6GZ79, Q6GZ82, Q6GZ83, Q6GZ84, Q6GZ85, Q6GZ87, Q6GZ89

UniProtKB/TrEMBL

B6ZGT2

Related

ENSP00000356961.4, ENST00000367982.8

Conserved Domains (2) summary

cd06934
Location:106 → 350

NR_LBD_PXR_like; The ligand binding domain of xenobiotic receptors:pregnane X receptor and constitutive androstane receptor

cd07156
Location:11 → 82

NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers
NM_001077481.3 → NP_001070949.1 nuclear receptor subfamily 1 group I member 3 isoform 4

See identical proteins and their annotated locations for NP_001070949.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 4) is shorter than isoform 1.

Source sequence(s)

AA918394, AL590714, BC121120, CB124867

Consensus CDS

CCDS41428.1

UniProtKB/TrEMBL

B6ZGT2

Related

ENSP00000356965.3, ENST00000367985.7

Conserved Domains (2) summary

cd07156
Location:11 → 82

NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers

cl11397
Location:106 → 312

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_001077482.3 → NP_001070950.1 nuclear receptor subfamily 1 group I member 3 isoform 1

See identical proteins and their annotated locations for NP_001070950.1

Status: REVIEWED

Description

Transcript Variant: This variant (1), also known as SV-25 or CAR2, represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AA918394, BC121120, CB124867, DQ022681

Consensus CDS

CCDS41429.1

UniProtKB/TrEMBL

B6ZGT2

Related

ENSP00000356959.2, ENST00000367980.6

Conserved Domains (2) summary

cd06934
Location:106 → 355

NR_LBD_PXR_like; The ligand binding domain of xenobiotic receptors:pregnane X receptor and constitutive androstane receptor

cd07156
Location:11 → 82

NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers
NM_005122.5 → NP_005113.1 nuclear receptor subfamily 1 group I member 3 isoform 3

See identical proteins and their annotated locations for NP_005113.1

Status: REVIEWED

Description

Transcript Variant: This variant (3), also known as WT or REF, uses two alternate splice sites in the 3' coding region, compared to variant 1. The resulting protein (isoform 3) is shorter than isoform 1.

Source sequence(s)

CB124867, Z30425

Consensus CDS

CCDS1228.1

UniProtKB/TrEMBL

B6ZGT2

Related

ENSP00000356962.5, ENST00000367983.9

Conserved Domains (2) summary

cd06934
Location:106 → 346

NR_LBD_PXR_like; The ligand binding domain of xenobiotic receptors:pregnane X receptor and constitutive androstane receptor

cd07156
Location:11 → 82

NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

161229669..161238203 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005245693.5 → XP_005245750.2 nuclear receptor subfamily 1 group I member 3 isoform X2

UniProtKB/TrEMBL

D6REZ7
XM_005245697.5 → XP_005245754.1 nuclear receptor subfamily 1 group I member 3 isoform X1

See identical proteins and their annotated locations for XP_005245754.1

UniProtKB/TrEMBL

B6ZGT2, F1DAL4

Conserved Domains (2) summary

cd06934
Location:106 → 351

NR_LBD_PXR_like; The ligand binding domain of xenobiotic receptors:pregnane X receptor and constitutive androstane receptor

cd07156
Location:11 → 82

NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

160367115..160375669 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054339984.1 → XP_054195959.1 nuclear receptor subfamily 1 group I member 3 isoform X2

UniProtKB/TrEMBL

D6REZ7
XM_054339983.1 → XP_054195958.1 nuclear receptor subfamily 1 group I member 3 isoform X1

UniProtKB/TrEMBL

B6ZGT2, F1DAL4