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    ELMO3 engulfment and cell motility 3 [ Homo sapiens (human) ]

    Gene ID: 79767, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ELMO3provided by HGNC
    Official Full Name
    engulfment and cell motility 3provided by HGNC
    Primary source
    HGNC:HGNC:17289
    See related
    Ensembl:ENSG00000102890 MIM:606422; AllianceGenome:HGNC:17289
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CED12; CED-12; ELMO-3
    Summary
    The protein encoded by this gene is similar to a C. elegans protein that functions in phagocytosis of apoptotic cells and in cell migration. Other members of this small family of engulfment and cell motility (ELMO) proteins have been shown to interact with the dedicator of cyto-kinesis 1 protein to promote phagocytosis and effect cell shape changes. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in duodenum (RPKM 15.2), skin (RPKM 12.9) and 20 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ELMO3 in Genome Data Viewer
    Location:
    16q22.1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (67199131..67204004)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (72993415..72998288)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67233034..67237907)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10956 Neighboring gene exocyst complex component 3 like 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67225781-67226711 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10958 Neighboring gene E2F transcription factor 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7593 Neighboring gene microRNA 328 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67241386-67241953 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67241954-67242520 Neighboring gene F-box and leucine rich repeat protein, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10959 Neighboring gene transmembrane protein 208

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ELMO3 - a Negative Prognostic Marker in Minor Salivary Gland Carcinoma. Kotowski U, et al. Pathol Oncol Res, 2019 Apr. PMID 30374620, Free PMC Article
    2. Silencing ELMO3 Inhibits the Growth, Invasion, and Metastasis of Gastric Cancer. Hu Y, et al. Biomed Res Int, 2018. PMID 30345300, Free PMC Article
    3. ELMO3 is a novel biomarker for diagnosis and prognosis of non-small cell lung cancer. Fan W, et al. Int J Clin Exp Pathol, 2015. PMID 26191257, Free PMC Article
    4. ELMO3 expression indicates a poor prognosis in head and neck squamous cell carcinoma - a short report. Kadletz L, et al. Cell Oncol (Dordr), 2017 Apr. PMID 28039609
    5. Knockdown of ELMO3 Suppresses Growth, Invasion and Metastasis of Colorectal Cancer. Peng HY, et al. Int J Mol Sci, 2016 Dec 16. PMID 27999268, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ELMO3 might serve as a clinical prognostic marker of patients with minor salivary gland carcinoma
      Title: ELMO3 - a Negative Prognostic Marker in Minor Salivary Gland Carcinoma.
    2. the results indicate that ELMO3 participates in the processes of cell growth, invasion, and migration, and ELMO3 is expected to be a potential diagnostic and prognostic marker for gastric cancer.
      Title: Silencing ELMO3 Inhibits the Growth, Invasion, and Metastasis of Gastric Cancer.
    3. the silencing of ELMO3 inhibited cell proliferation, invasion, metastasis, and F-actin polymerization, and induced Gap 1 (G1) phase cell cycle arrest, demonstrating that ELMO3 is involved in the processes of growth, invasion and metastasis of Colorectal Cancer
      Title: Knockdown of ELMO3 Suppresses Growth, Invasion and Metastasis of Colorectal Cancer.
    4. The purpose of this study was to asses ELMO3 expression in postoperatively irradiated head and neck squamous cell carcinoma patients.
      Title: ELMO3 expression indicates a poor prognosis in head and neck squamous cell carcinoma - a short report.
    5. The over-expression of ELMO3 was a potential diagnostic and prognostic marker for non-small cell lung cancer.
      Title: ELMO3 is a novel biomarker for diagnosis and prognosis of non-small cell lung cancer.
    6. The present study reports the first characterization of the ELMO3 promoter and suggests a significant role of CDX2 in the basal transcriptional regulation of the intestine-specific expression of ELMO3, possibly through interaction with SP1.
      Title: Control of intestinal promoter activity of the cellular migratory regulator gene ELMO3 by CDX2 and SP1.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ13824

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phagocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    engulfment and cell motility protein 3
    Names
    ced-12 homolog 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024712.5 → NP_078988.3  engulfment and cell motility protein 3

      Status: REVIEWED

      Source sequence(s)
      AC040160, BC034410, DA872517
      Consensus CDS
      CCDS10833.3
      UniProtKB/Swiss-Prot
      B4DV86, Q96BJ8, Q9H8A5
      UniProtKB/TrEMBL
      F8W9E7
      Related
      ENSP00000377566.3, ENST00000393997.8
      Conserved Domains (3) summary
      cd13359
      Location:534 → 663
      PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
      pfam04727
      Location:292 → 463
      ELMO_CED12; ELMO/CED-12 family
      pfam11841
      Location:116 → 267
      DUF3361; Domain of unknown function (DUF3361)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      67199131..67204004
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024450447.2 → XP_024306215.1  engulfment and cell motility protein 3 isoform X1

      Conserved Domains (3) summary
      pfam04727
      Location:115 → 286
      ELMO_CED12; ELMO/CED-12 family
      pfam11841
      Location:3 → 90
      DUF3361; Domain of unknown function (DUF3361)
      cl17171
      Location:357 → 486
      PH-like; Pleckstrin homology-like domain

    RNA

    1. XR_007064916.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      72993415..72998288
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054313943.1 → XP_054169918.1  engulfment and cell motility protein 3 isoform X1

    RNA

    1. XR_008484738.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96BJ8.3 GenPept UniProtKB/Swiss-Prot:Q96BJ8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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