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    Mirt2 myocardial infraction associated transcript 2 [ Mus musculus (house mouse) ]

    Gene ID: 100038659, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Mirt2provided by MGI
    Official Full Name
    myocardial infraction associated transcript 2provided by MGI
    Primary source
    MGI:MGI:3642813
    See related
    AllianceGenome:MGI:3642813
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm10872; Gm24562
    Summary
    Acts upstream of or within response to wounding. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 19.3) and kidney adult (RPKM 3.4) See more
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    Genomic context

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    See Mirt2 in Genome Data Viewer
    Location:
    15 D3; 15
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76150987..76154039, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76266787..76269839, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene poly (ADP-ribose) polymerase family, member 10 Neighboring gene microRNA 6953 Neighboring gene glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) Neighboring gene spermatogenesis and centriole associated 1 Neighboring gene microRNA 3079 Neighboring gene sphingomyelin phosphodiesterase 5 Neighboring gene 5-oxoprolinase (ATP-hydrolysing)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The LPS-inducible lncRNA Mirt2 is a negative regulator of inflammation. Du M, et al. Nat Commun, 2017 Dec 11. PMID 29230038, Free PMC Article
    2. Mirt2 functions in synergy with miR-377 to participate in inflammatory pathophysiology of Sjögren's syndrome. Xin M, et al. Artif Cells Nanomed Biotechnol, 2019 Dec. PMID 31198060
    3. Long noncoding RNA Mirt2 upregulates USP10 expression to suppress hepatic steatosis by sponging miR-34a-5p. Zhang B, et al. Gene, 2019 Jun 5. PMID 30898698
    4. Identification of candidate long non-coding RNAs in response to myocardial infarction. Zangrando J, et al. BMC Genomics, 2014 Jun 10. PMID 24917243, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study found that Mirt2 was decreased in obese mice and fasting mice suggesting that Mirt2 is a suppressor of hepatic steatosis and insulin resistance. Also, the data demonstrated that Mirt2 significantly inhibited hepatic steatosis and insulin resistance by regulating miR-34a-5p/USP10 axis.
      Title: Long noncoding RNA Mirt2 upregulates USP10 expression to suppress hepatic steatosis by sponging miR-34a-5p.
    2. Findings indicate long non-coding RNA (lncRNA) Mirt2 as a negative feedback regulator of excessive inflammation.
      Title: The LPS-inducible lncRNA Mirt2 is a negative regulator of inflammation.
    3. gene expression regulation study shows that long non-coding RNAS MIRT1 and MIRT2 are up-regulated in response to myocardial infarction. [MIRT1] & [MIRT2].
      Title: Identification of candidate long non-coding RNAs in response to myocardial infarction.
    Submit: New GeneRIF Correction

    General gene information

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    Other Names

    • myocardial infarction-associated transcript 2

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_045747.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC110211

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      76150987..76154039 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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