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    TRIM37 tripartite motif containing 37 [ Homo sapiens (human) ]

    Gene ID: 4591, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TRIM37provided by HGNC
    Official Full Name
    tripartite motif containing 37provided by HGNC
    Primary source
    HGNC:HGNC:7523
    See related
    Ensembl:ENSG00000108395 MIM:605073; AllianceGenome:HGNC:7523
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MUL; POB1; TEF3
    Summary
    This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. Mutations in this gene are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. TRIM37 localizes in peroxisomal membranes, and has been implicated in human peroxisomal biogenesis disorders. [provided by RefSeq, Jul 2020]
    Expression
    Broad expression in testis (RPKM 19.8), brain (RPKM 14.1) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TRIM37 in Genome Data Viewer
    Location:
    17q22
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (58967201..59106880, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (59835276..59974976, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (57060010..57184241, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1E Neighboring gene RNA, U6 small nuclear 518, pseudogene Neighboring gene ribosomal protein S12 pseudogene 30 Neighboring gene MPRA-validated peak2922 silencer Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:57078614-57079813 Neighboring gene RNA, 7SL, cytoplasmic 716, pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:57183329-57183988 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:57183989-57184648 Neighboring gene uncharacterized LOC124904039 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12499 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12500 Neighboring gene RNA, U2 small nuclear 58, pseudogene Neighboring gene spindle and kinetochore associated complex subunit 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TRIM37 interacts with EZH2 to epigenetically suppress PTCH1 and regulate stemness in glioma stem cells through sonic hedgehog pathway.
      Title: TRIM37 interacts with EZH2 to epigenetically suppress PTCH1 and regulate stemness in glioma stem cells through sonic hedgehog pathway.
    2. TRIM37 promotes the aggressiveness of ovarian cancer cells and increases c-Myc expression by binding to HUWE1.
      Title: TRIM37 promotes the aggressiveness of ovarian cancer cells and increases c-Myc expression by binding to HUWE1.
    3. TRIM37 Augments AP-2gamma Transcriptional Activity and Cellular Localization via K63-linked Ubiquitination to Drive Breast Cancer Progression.
      Title: TRIM37 Augments AP-2γ Transcriptional Activity and Cellular Localization via K63-linked Ubiquitination to Drive Breast Cancer Progression.
    4. Liver pathology and biochemistry in patients with mutations in TRIM37 gene (Mulibrey nanism).
      Title: Liver pathology and biochemistry in patients with mutations in TRIM37 gene (Mulibrey nanism).
    5. TRIM37 Promotes Pancreatic Cancer Progression through Modulation of Cell Growth, Migration, Invasion, and Tumor Immune Microenvironment.
      Title: TRIM37 Promotes Pancreatic Cancer Progression through Modulation of Cell Growth, Migration, Invasion, and Tumor Immune Microenvironment.
    6. TRIM37 prevents formation of centriolar protein assemblies by regulating Centrobin.
      Title: TRIM37 prevents formation of centriolar protein assemblies by regulating Centrobin.
    7. Circular RNA circRNA_101996 promoted cervical cancer development by regulating miR-1236-3p/TRIM37 axis.
      Title: Circular RNA circRNA_101996 promoted cervical cancer development by regulating miR-1236-3p/TRIM37 axis.
    8. TRIM37 orchestrates renal cell carcinoma progression via histone H2A ubiquitination-dependent manner.
      Title: TRIM37 orchestrates renal cell carcinoma progression via histone H2A ubiquitination-dependent manner.
    9. ASB16-AS1 up-regulated and phosphorylated TRIM37 to activate NF-kappaB pathway and promote proliferation, stemness, and cisplatin resistance of gastric cancer.
      Title: ASB16-AS1 up-regulated and phosphorylated TRIM37 to activate NF-κB pathway and promote proliferation, stemness, and cisplatin resistance of gastric cancer.
    10. TRIM37 prevents formation of condensate-organized ectopic spindle poles to ensure mitotic fidelity.
      Title: TRIM37 prevents formation of condensate-organized ectopic spindle poles to ensure mitotic fidelity.
    Submit: New GeneRIF Correction See all GeneRIFs (38)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Mulibrey nanism syndrome
    MedGen: C0524582 OMIM: 253250 GeneReviews: Not available
    		not available

    EBI GWAS Catalog

    Description
    Meta-analysis identifies four new loci associated with testicular germ cell tumor.
    EBI GWAS Catalog

    Variation

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    See Variation Viewer (GRCh37.p13)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0898

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AK119 ubiquitin ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tumor necrosis factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tumor necrosis factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aggresome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in aggresome assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of centriole replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression, epigenetic IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein autoubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein autoubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of protein import into peroxisome matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein monoubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein monoubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein stabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ESC/E(Z) complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ESC/E(Z) complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in aggresome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in aggresome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in peroxisomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase TRIM37
    Names
    RING-B-box-coiled-coil protein
    RING-type E3 ubiquitin transferase TRIM37
    mulibrey nanism protein
    NP_001005207.1
    NP_001307916.1
    NP_001307917.1
    NP_001307918.1
    NP_001307919.1
    NP_001340011.1
    NP_001340012.1
    NP_001340013.1
    NP_001340014.1
    NP_001340015.1
    NP_056109.1
    XP_005257442.1
    XP_011523133.1
    XP_011523134.1
    XP_011523135.1
    XP_011523136.1
    XP_011523138.1
    XP_016880151.1
    XP_016880152.1
    XP_016880154.1
    XP_016880156.1
    XP_016880158.1
    XP_016880159.1
    XP_016880162.1
    XP_047292062.1
    XP_047292063.1
    XP_047292064.1
    XP_047292065.1
    XP_047292066.1
    XP_047292067.1
    XP_047292068.1
    XP_047292069.1
    XP_047292070.1
    XP_047292071.1
    XP_047292072.1
    XP_047292073.1
    XP_047292074.1
    XP_047292075.1
    XP_047292076.1
    XP_047292077.1
    XP_047292078.1
    XP_047292079.1
    XP_047292080.1
    XP_047292081.1
    XP_047292082.1
    XP_054172173.1
    XP_054172174.1
    XP_054172175.1
    XP_054172176.1
    XP_054172177.1
    XP_054172178.1
    XP_054172179.1
    XP_054172180.1
    XP_054172181.1
    XP_054172182.1
    XP_054172183.1
    XP_054172184.1
    XP_054172185.1
    XP_054172186.1
    XP_054172187.1
    XP_054172188.1
    XP_054172189.1
    XP_054172190.1
    XP_054172191.1
    XP_054172192.1
    XP_054172193.1
    XP_054172194.1
    XP_054172195.1
    XP_054172196.1
    XP_054172197.1
    XP_054172198.1
    XP_054172199.1
    XP_054172200.1
    XP_054172201.1
    XP_054172202.1
    XP_054172203.1
    XP_054172204.1
    XP_054172205.1
    XP_054172206.1
    XP_054172207.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009298.2 RefSeqGene

      Range
      5000..113678
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001005207.5 → NP_001005207.1  E3 ubiquitin-protein ligase TRIM37 isoform a

      See identical proteins and their annotated locations for NP_001005207.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) and variant 1 encode the same isoform (a).
      Source sequence(s)
      AI307801, AK292459, BC036012, DC351295
      Consensus CDS
      CCDS45746.1
      UniProtKB/Swiss-Prot
      A8K0V9, A8K8U4, A8MZ79, B4DGZ3, F8WEE6, O94972, Q7Z3E6, Q8IYF7, Q8WYF7
      Related
      ENSP00000376785.3, ENST00000393066.7
      Conserved Domains (4) summary
      smart00502
      Location:132 → 254
      BBC; B-Box C-terminal domain
      cd00162
      Location:15 → 58
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd03773
      Location:273 → 406
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      pfam00643
      Location:90 → 132
      zf-B_box; B-box zinc finger

    2. NM_001320987.3 → NP_001307916.1  E3 ubiquitin-protein ligase TRIM37 isoform b

      Status: REVIEWED

      Source sequence(s)
      AB020705, AC099850, AC100832, AI610736, AK294850, DC343932
      Consensus CDS
      CCDS82174.1
      UniProtKB/Swiss-Prot
      O94972
      Related
      ENSP00000376784.2, ENST00000393065.6
      Conserved Domains (3) summary
      smart00502
      Location:98 → 220
      BBC; B-Box C-terminal domain
      cd03773
      Location:239 → 372
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      pfam00643
      Location:56 → 98
      zf-B_box; B-box zinc finger

    3. NM_001320988.3 → NP_001307917.1  E3 ubiquitin-protein ligase TRIM37 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) and variant 5 encode the same isoform (c).
      Source sequence(s)
      AC005207, AC036154, AC099850, AC100832
      Conserved Domains (4) summary
      smart00502
      Location:132 → 254
      BBC; B-Box C-terminal domain
      cd00162
      Location:15 → 58
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd03773
      Location:273 → 406
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      pfam00643
      Location:90 → 132
      zf-B_box; B-box zinc finger

    4. NM_001320989.3 → NP_001307918.1  E3 ubiquitin-protein ligase TRIM37 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) and variant 4 encode the same isoform (c).
      Source sequence(s)
      AC005207, AC036154, AC099850, AC100832
      Conserved Domains (4) summary
      smart00502
      Location:132 → 254
      BBC; B-Box C-terminal domain
      cd00162
      Location:15 → 58
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd03773
      Location:273 → 406
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      pfam00643
      Location:90 → 132
      zf-B_box; B-box zinc finger

    5. NM_001320990.3 → NP_001307919.1  E3 ubiquitin-protein ligase TRIM37 isoform d

      Status: REVIEWED

      Source sequence(s)
      AC100832, BX537955, DC343932
      UniProtKB/Swiss-Prot
      O94972
      Conserved Domains (2) summary
      smart00502
      Location:10 → 132
      BBC; B-Box C-terminal domain
      cd03773
      Location:151 → 284
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

    6. NM_001353082.2 → NP_001340011.1  E3 ubiquitin-protein ligase TRIM37 isoform e

      Status: REVIEWED

      Source sequence(s)
      AC005207, AC036154, AC099850, AC100832
      Conserved Domains (4) summary
      smart00502
      Location:98 → 220
      BBC; B-Box C-terminal domain
      smart00336
      Location:57 → 98
      BBOX; B-Box-type zinc finger
      cd03773
      Location:239 → 372
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      cl17238
      Location:6 → 21
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    7. NM_001353083.2 → NP_001340012.1  E3 ubiquitin-protein ligase TRIM37 isoform f

      Status: REVIEWED

      Source sequence(s)
      AC005207, AC036154, AC099850, AC100832
      Conserved Domains (1) summary
      cd03773
      Location:28 → 161
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

    8. NM_001353084.2 → NP_001340013.1  E3 ubiquitin-protein ligase TRIM37 isoform g

      Status: REVIEWED

      Source sequence(s)
      AC005207, AC036154, AC099850, AC100832
      Conserved Domains (4) summary
      smart00502
      Location:132 → 254
      BBC; B-Box C-terminal domain
      smart00336
      Location:91 → 132
      BBOX; B-Box-type zinc finger
      cd03773
      Location:273 → 406
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      cd16619
      Location:13 → 55
      mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins

    9. NM_001353085.2 → NP_001340014.1  E3 ubiquitin-protein ligase TRIM37 isoform h

      Status: REVIEWED

      Source sequence(s)
      AC005207, AC036154, AC099850, AC100832
      Conserved Domains (2) summary
      cd03773
      Location:119 → 252
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      cl25407
      Location:1 → 100
      ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

    10. NM_001353086.2 → NP_001340015.1  E3 ubiquitin-protein ligase TRIM37 isoform i

      Status: REVIEWED

      Source sequence(s)
      AC005207, AC036154, AC099850, AC100832
      Conserved Domains (4) summary
      smart00502
      Location:132 → 254
      BBC; B-Box C-terminal domain
      smart00336
      Location:91 → 132
      BBOX; B-Box-type zinc finger
      cd03773
      Location:270 → 389
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      cd16619
      Location:13 → 55
      mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins

    11. NM_015294.6 → NP_056109.1  E3 ubiquitin-protein ligase TRIM37 isoform a

      See identical proteins and their annotated locations for NP_056109.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) and variant 2 encode the same isoform (a).
      Source sequence(s)
      AB020705, AK289674, CN388771, DC351295
      Consensus CDS
      CCDS32694.1
      UniProtKB/Swiss-Prot
      A8K0V9, A8K8U4, A8MZ79, B4DGZ3, F8WEE6, O94972, Q7Z3E6, Q8IYF7, Q8WYF7
      Related
      ENSP00000262294.7, ENST00000262294.12
      Conserved Domains (4) summary
      smart00502
      Location:132 → 254
      BBC; B-Box C-terminal domain
      cd00162
      Location:15 → 58
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd03773
      Location:273 → 406
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      pfam00643
      Location:90 → 132
      zf-B_box; B-box zinc finger

    RNA

    1. NR_148346.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC005207, AC036154, AC099850, AC100832
      Related
      ENST00000577554.5

    2. NR_148347.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC005207, AC036154, AC099850, AC100832

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      58967201..59106880 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047436110.1 → XP_047292066.1  E3 ubiquitin-protein ligase TRIM37 isoform X13

    2. XM_047436107.1 → XP_047292063.1  E3 ubiquitin-protein ligase TRIM37 isoform X9

    3. XM_047436111.1 → XP_047292067.1  E3 ubiquitin-protein ligase TRIM37 isoform X15

    4. XM_017024663.3 → XP_016880152.1  E3 ubiquitin-protein ligase TRIM37 isoform X4

    5. XM_017024662.2 → XP_016880151.1  E3 ubiquitin-protein ligase TRIM37 isoform X2

    6. XM_047436122.1 → XP_047292078.1  E3 ubiquitin-protein ligase TRIM37 isoform X29

    7. XM_047436121.1 → XP_047292077.1  E3 ubiquitin-protein ligase TRIM37 isoform X28

    8. XM_047436114.1 → XP_047292070.1  E3 ubiquitin-protein ligase TRIM37 isoform X19

    9. XM_047436113.1 → XP_047292069.1  E3 ubiquitin-protein ligase TRIM37 isoform X18

    10. XM_047436117.1 → XP_047292073.1  E3 ubiquitin-protein ligase TRIM37 isoform X23

    11. XM_017024667.2 → XP_016880156.1  E3 ubiquitin-protein ligase TRIM37 isoform X16

      Conserved Domains (4) summary
      smart00502
      Location:132 → 254
      BBC; B-Box C-terminal domain
      smart00336
      Location:91 → 132
      BBOX; B-Box-type zinc finger
      cd03773
      Location:270 → 389
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      cd16619
      Location:13 → 55
      mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins

    12. XM_047436108.1 → XP_047292064.1  E3 ubiquitin-protein ligase TRIM37 isoform X10

    13. XM_047436123.1 → XP_047292079.1  E3 ubiquitin-protein ligase TRIM37 isoform X30

    14. XM_047436116.1 → XP_047292072.1  E3 ubiquitin-protein ligase TRIM37 isoform X21

    15. XM_047436115.1 → XP_047292071.1  E3 ubiquitin-protein ligase TRIM37 isoform X20

    16. XM_005257385.2 → XP_005257442.1  E3 ubiquitin-protein ligase TRIM37 isoform X6

      Conserved Domains (4) summary
      smart00502
      Location:132 → 254
      BBC; B-Box C-terminal domain
      smart00336
      Location:91 → 132
      BBOX; B-Box-type zinc finger
      cd03773
      Location:273 → 406
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      cd16619
      Location:13 → 55
      mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins

    17. XM_011524832.3 → XP_011523134.1  E3 ubiquitin-protein ligase TRIM37 isoform X3

      Conserved Domains (4) summary
      smart00502
      Location:132 → 254
      BBC; B-Box C-terminal domain
      cd00162
      Location:15 → 58
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd03773
      Location:273 → 406
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      pfam00643
      Location:90 → 132
      zf-B_box; B-box zinc finger

    18. XM_017024665.2 → XP_016880154.1  E3 ubiquitin-protein ligase TRIM37 isoform X11

    19. XM_047436106.1 → XP_047292062.1  E3 ubiquitin-protein ligase TRIM37 isoform X7

    20. XM_047436109.1 → XP_047292065.1  E3 ubiquitin-protein ligase TRIM37 isoform X12

    21. XM_011524831.2 → XP_011523133.1  E3 ubiquitin-protein ligase TRIM37 isoform X1

      Conserved Domains (4) summary
      smart00502
      Location:132 → 254
      BBC; B-Box C-terminal domain
      cd00162
      Location:15 → 58
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd03773
      Location:273 → 406
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      pfam00643
      Location:90 → 132
      zf-B_box; B-box zinc finger

    22. XM_011524836.2 → XP_011523138.1  E3 ubiquitin-protein ligase TRIM37 isoform X14

      Conserved Domains (4) summary
      smart00502
      Location:132 → 254
      BBC; B-Box C-terminal domain
      cd00162
      Location:15 → 58
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd03773
      Location:273 → 406
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      pfam00643
      Location:90 → 132
      zf-B_box; B-box zinc finger

    23. XM_047436112.1 → XP_047292068.1  E3 ubiquitin-protein ligase TRIM37 isoform X17

    24. XM_011524834.2 → XP_011523136.1  E3 ubiquitin-protein ligase TRIM37 isoform X8

      Conserved Domains (3) summary
      smart00502
      Location:98 → 220
      BBC; B-Box C-terminal domain
      cd03773
      Location:239 → 372
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      pfam00643
      Location:56 → 98
      zf-B_box; B-box zinc finger

    25. XM_011524833.2 → XP_011523135.1  E3 ubiquitin-protein ligase TRIM37 isoform X5

      Conserved Domains (4) summary
      smart00502
      Location:132 → 254
      BBC; B-Box C-terminal domain
      cd00162
      Location:15 → 58
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd03773
      Location:270 → 389
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      pfam00643
      Location:90 → 132
      zf-B_box; B-box zinc finger

    26. XM_047436118.1 → XP_047292074.1  E3 ubiquitin-protein ligase TRIM37 isoform X24

    27. XM_017024673.3 → XP_016880162.1  E3 ubiquitin-protein ligase TRIM37 isoform X34

    28. XM_047436125.1 → XP_047292081.1  E3 ubiquitin-protein ligase TRIM37 isoform X32

    29. XM_047436124.1 → XP_047292080.1  E3 ubiquitin-protein ligase TRIM37 isoform X31

    30. XM_017024669.3 → XP_016880158.1  E3 ubiquitin-protein ligase TRIM37 isoform X22

    31. XM_047436126.1 → XP_047292082.1  E3 ubiquitin-protein ligase TRIM37 isoform X33

    32. XM_047436120.1 → XP_047292076.1  E3 ubiquitin-protein ligase TRIM37 isoform X26

    33. XM_017024670.3 → XP_016880159.1  E3 ubiquitin-protein ligase TRIM37 isoform X27

    34. XM_047436119.1 → XP_047292075.1  E3 ubiquitin-protein ligase TRIM37 isoform X25

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      59835276..59974976 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316201.1 → XP_054172176.1  E3 ubiquitin-protein ligase TRIM37 isoform X4

    2. XM_054316210.1 → XP_054172185.1  E3 ubiquitin-protein ligase TRIM37 isoform X13

    3. XM_054316212.1 → XP_054172187.1  E3 ubiquitin-protein ligase TRIM37 isoform X15

    4. XM_054316206.1 → XP_054172181.1  E3 ubiquitin-protein ligase TRIM37 isoform X9

    5. XM_054316199.1 → XP_054172174.1  E3 ubiquitin-protein ligase TRIM37 isoform X2

    6. XM_054316226.1 → XP_054172201.1  E3 ubiquitin-protein ligase TRIM37 isoform X29

    7. XM_054316225.1 → XP_054172200.1  E3 ubiquitin-protein ligase TRIM37 isoform X28

    8. XM_054316216.1 → XP_054172191.1  E3 ubiquitin-protein ligase TRIM37 isoform X19

    9. XM_054316215.1 → XP_054172190.1  E3 ubiquitin-protein ligase TRIM37 isoform X18

    10. XM_054316220.1 → XP_054172195.1  E3 ubiquitin-protein ligase TRIM37 isoform X23

    11. XM_054316213.1 → XP_054172188.1  E3 ubiquitin-protein ligase TRIM37 isoform X16

    12. XM_054316207.1 → XP_054172182.1  E3 ubiquitin-protein ligase TRIM37 isoform X10

    13. XM_054316227.1 → XP_054172202.1  E3 ubiquitin-protein ligase TRIM37 isoform X30

    14. XM_054316218.1 → XP_054172193.1  E3 ubiquitin-protein ligase TRIM37 isoform X21

    15. XM_054316217.1 → XP_054172192.1  E3 ubiquitin-protein ligase TRIM37 isoform X20

    16. XM_054316203.1 → XP_054172178.1  E3 ubiquitin-protein ligase TRIM37 isoform X6

    17. XM_054316200.1 → XP_054172175.1  E3 ubiquitin-protein ligase TRIM37 isoform X3

    18. XM_054316208.1 → XP_054172183.1  E3 ubiquitin-protein ligase TRIM37 isoform X11

    19. XM_054316204.1 → XP_054172179.1  E3 ubiquitin-protein ligase TRIM37 isoform X7

    20. XM_054316209.1 → XP_054172184.1  E3 ubiquitin-protein ligase TRIM37 isoform X12

    21. XM_054316198.1 → XP_054172173.1  E3 ubiquitin-protein ligase TRIM37 isoform X1

    22. XM_054316211.1 → XP_054172186.1  E3 ubiquitin-protein ligase TRIM37 isoform X14

    23. XM_054316214.1 → XP_054172189.1  E3 ubiquitin-protein ligase TRIM37 isoform X17

    24. XM_054316205.1 → XP_054172180.1  E3 ubiquitin-protein ligase TRIM37 isoform X8

    25. XM_054316202.1 → XP_054172177.1  E3 ubiquitin-protein ligase TRIM37 isoform X5

    26. XM_054316221.1 → XP_054172196.1  E3 ubiquitin-protein ligase TRIM37 isoform X24

    27. XM_054316231.1 → XP_054172206.1  E3 ubiquitin-protein ligase TRIM37 isoform X35

    28. XM_054316232.1 → XP_054172207.1  E3 ubiquitin-protein ligase TRIM37 isoform X34

    29. XM_054316229.1 → XP_054172204.1  E3 ubiquitin-protein ligase TRIM37 isoform X32

    30. XM_054316228.1 → XP_054172203.1  E3 ubiquitin-protein ligase TRIM37 isoform X31

    31. XM_054316219.1 → XP_054172194.1  E3 ubiquitin-protein ligase TRIM37 isoform X22

    32. XM_054316230.1 → XP_054172205.1  E3 ubiquitin-protein ligase TRIM37 isoform X33

    33. XM_054316223.1 → XP_054172198.1  E3 ubiquitin-protein ligase TRIM37 isoform X26

    34. XM_054316224.1 → XP_054172199.1  E3 ubiquitin-protein ligase TRIM37 isoform X27

    35. XM_054316222.1 → XP_054172197.1  E3 ubiquitin-protein ligase TRIM37 isoform X25

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O94972.2 GenPept UniProtKB/Swiss-Prot:O94972

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