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    MPP3 MAGUK p55 scaffold protein 3 [ Homo sapiens (human) ]

    Gene ID: 4356, updated on 28-Oct-2024

    Summary

    Official Symbol
    MPP3provided by HGNC
    Official Full Name
    MAGUK p55 scaffold protein 3provided by HGNC
    Primary source
    HGNC:HGNC:7221
    See related
    Ensembl:ENSG00000161647 MIM:601114; AllianceGenome:HGNC:7221
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DLG3
    Summary
    This gene product is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. This protein contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction. Alternatively spliced transcript variants have been identified. One transcript variant is experimentally supported, but it doesn't encode a protein. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in heart (RPKM 3.1), lung (RPKM 2.5) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MPP3 in Genome Data Viewer
    Location:
    17q21.31
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (43800811..43833146, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (44653356..44685702, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (41878179..41910514, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene dual specificity phosphatase 3 Neighboring gene Sharpr-MPRA regulatory region 13819 Neighboring gene CFAP97 domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8568 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8569 Neighboring gene uncharacterized LOC107984979 Neighboring gene uncharacterized LOC107985077 Neighboring gene CD300 molecule like family member g

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables PDZ domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in adherens junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    MAGUK p55 subfamily member 3
    Names
    discs, large homolog 3
    membrane palmitoylated protein 3
    membrane protein palmitoylated 3
    membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330233.2NP_001317162.1  MAGUK p55 subfamily member 3 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC003098, U37707
      Consensus CDS
      CCDS82135.1
      UniProtKB/TrEMBL
      D3DX46
      Related
      ENSP00000381430.1, ENST00000398393.5
    2. NM_001353080.2NP_001340009.1  MAGUK p55 subfamily member 3 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC003098
      Conserved Domains (4) summary
      smart00569
      Location:81129
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12039
      Location:238299
      SH3_MPP3; Src Homology 3 domain of Membrane Protein, Palmitoylated 3 (or MAGUK p55 subfamily member 3)
      smart00072
      Location:403579
      GuKc; Guanylate kinase homologues
      cd00992
      Location:143223
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    3. NM_001932.6NP_001923.2  MAGUK p55 subfamily member 3 isoform 1

      See identical proteins and their annotated locations for NP_001923.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the shortest isoform (1).
      Source sequence(s)
      BC056865, DA585178, DB357996, U37707
      Consensus CDS
      CCDS42344.1
      UniProtKB/Swiss-Prot
      A0A0C4DGP3, B2R7N0, D3DX47, Q13368, Q4GX05, Q6PGR3, Q86SV1
      Related
      ENSP00000381425.4, ENST00000398389.9
      Conserved Domains (4) summary
      smart00569
      Location:71121
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12039
      Location:230291
      SH3_MPP3; Src Homology 3 domain of Membrane Protein, Palmitoylated 3 (or MAGUK p55 subfamily member 3)
      smart00072
      Location:395571
      GuKc; Guanylate kinase homologues
      cd00992
      Location:135215
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    RNA

    1. NR_003562.4 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the coding region, compared to variant 1, which results in a frameshift and early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein is not represented because the product is significantly truncated and the transcript is a candidate for nonsense-mediated decay (NMD).
      Source sequence(s)
      BC047017, DB357996, U37707
    2. NR_148342.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC003098
    3. NR_148343.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC003098
    4. NR_148344.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC003098
    5. NR_148345.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC003098

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      43800811..43833146 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006721915.3XP_006721978.1  MAGUK p55 subfamily member 3 isoform X1

      See identical proteins and their annotated locations for XP_006721978.1

      UniProtKB/Swiss-Prot
      A0A0C4DGP3, B2R7N0, D3DX47, Q13368, Q4GX05, Q6PGR3, Q86SV1
      Conserved Domains (4) summary
      smart00569
      Location:71121
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12039
      Location:230291
      SH3_MPP3; Src Homology 3 domain of Membrane Protein, Palmitoylated 3 (or MAGUK p55 subfamily member 3)
      smart00072
      Location:395571
      GuKc; Guanylate kinase homologues
      cd00992
      Location:135215
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    2. XM_017024656.2XP_016880145.1  MAGUK p55 subfamily member 3 isoform X2

      Conserved Domains (3) summary
      cd12039
      Location:2889
      SH3_MPP3; Src Homology 3 domain of Membrane Protein, Palmitoylated 3 (or MAGUK p55 subfamily member 3)
      smart00072
      Location:193369
      GuKc; Guanylate kinase homologues
      pfam00625
      Location:182370
      Guanylate_kin; Guanylate kinase
    3. XM_047436098.1XP_047292054.1  MAGUK p55 subfamily member 3 isoform X3

    4. XM_047436102.1XP_047292058.1  MAGUK p55 subfamily member 3 isoform X5

      Related
      ENSP00000465486.1, ENST00000496503.5
    5. XM_047436099.1XP_047292055.1  MAGUK p55 subfamily member 3 isoform X3

    6. XM_017024658.2XP_016880147.1  MAGUK p55 subfamily member 3 isoform X5

      UniProtKB/TrEMBL
      B4DS20
    7. XM_047436103.1XP_047292059.1  MAGUK p55 subfamily member 3 isoform X6

    8. XM_047436097.1XP_047292053.1  MAGUK p55 subfamily member 3 isoform X3

    9. XM_047436101.1XP_047292057.1  MAGUK p55 subfamily member 3 isoform X5

    10. XM_047436100.1XP_047292056.1  MAGUK p55 subfamily member 3 isoform X4

    RNA

    1. XR_007065299.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      44653356..44685702 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316184.1XP_054172159.1  MAGUK p55 subfamily member 3 isoform X1

      UniProtKB/Swiss-Prot
      A0A0C4DGP3, B2R7N0, D3DX47, Q13368, Q4GX05, Q6PGR3, Q86SV1
    2. XM_054316186.1XP_054172161.1  MAGUK p55 subfamily member 3 isoform X2

    3. XM_054316195.1XP_054172170.1  MAGUK p55 subfamily member 3 isoform X9

    4. XM_054316185.1XP_054172160.1  MAGUK p55 subfamily member 3 isoform X7

    5. XM_054316188.1XP_054172163.1  MAGUK p55 subfamily member 3 isoform X3

    6. XM_054316192.1XP_054172167.1  MAGUK p55 subfamily member 3 isoform X5

    7. XM_054316189.1XP_054172164.1  MAGUK p55 subfamily member 3 isoform X3

    8. XM_054316194.1XP_054172169.1  MAGUK p55 subfamily member 3 isoform X6

    9. XM_054316191.1XP_054172166.1  MAGUK p55 subfamily member 3 isoform X5

    10. XM_054316187.1XP_054172162.1  MAGUK p55 subfamily member 3 isoform X3

    11. XM_054316190.1XP_054172165.1  MAGUK p55 subfamily member 3 isoform X4

    12. XM_054316193.1XP_054172168.1  MAGUK p55 subfamily member 3 isoform X8

    RNA

    1. XR_008484821.1 RNA Sequence