LYPD2 LY6/PLAUR domain containing 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LYPD2provided by HGNC
Official Full Name: LY6/PLAUR domain containing 2provided by HGNC
Primary source: HGNC:HGNC:25215
See related: Ensembl:ENSG00000197353 AllianceGenome:HGNC:25215
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LYPDC2; UNQ430
Summary: Predicted to be located in extracellular region and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in esophagus (RPKM 24.8), stomach (RPKM 10.7) and 1 other tissue See more
Orthologs: mouse all
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Genomic context

Location:: 8q24.3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (142750150..142752532, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (143893543..143895925, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (143831568..143833950, complement)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	TAS Traceable Author Statement more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ly6/PLAUR domain-containing protein 2

Names: RGTR430

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205545.3 → NP_991108.1 ly6/PLAUR domain-containing protein 2 precursor

See identical proteins and their annotated locations for NP_991108.1

Status: VALIDATED

Source sequence(s)

AY358432, DA449804

Consensus CDS

CCDS6388.1

UniProtKB/Swiss-Prot

A8K2R6, Q0VD64, Q0VF31, Q6UXB3

UniProtKB/TrEMBL

F1T0L0

Related

ENSP00000352163.3, ENST00000359228.4

Conserved Domains (1) summary

cd00117
Location:23 → 102

LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...